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    Method for inhibiting infection and reproduction of influenza type A WSN virus
    4.
    发明申请
    Method for inhibiting infection and reproduction of influenza type A WSN virus 审中-公开
    抑制A型流感病毒感染和繁殖的方法

    公开(公告)号：US20090042801A1

    公开(公告)日：2009-02-12

    申请号：US12285349

    申请日：2008-10-02

    申请人： Chuang Chun Chiueh ,  Shin Ru Shih

    发明人： Chuang Chun Chiueh ,  Shin Ru Shih

    IPC分类号： A61K38/00 ,  A61P31/12

    CPC分类号： A61K31/409 ,  A61K35/748 ,  A61K38/164 ,  A61K2300/00

    摘要： The present invention relates to a method for inhibiting infection and reproduction of influenza type A WSN virus, which comprises providing an effective amount of a pharmaceutical composition; and contacting said composition with said influenza type A WSN virus, wherein said pharmaceutical composition contains C-phycocyanin (C-PC), allophycocyanin (APC), and spirulina growth factor (SGF). The present invention also provides a method for extracting said pharmaceutical composition, comprising the steps of: (a) adding hypotonic buffer solution to organic blue-green algae powder and mixing thoroughly; (b) incubating the mixture below room temperature overnight; (c) separating and purifying the mixture by a centrifuge; (d) collecting the suspending supernatant and detecting it by a spectrometer to determine ingredients and content; and (e) spray drying the supernatant; characterized in which low-temperature extraction is employed to maintain the bioactivity and nutrients of the pharmaceutical composition.

    摘要翻译： 本发明涉及一种抑制A型流感病毒感染和繁殖的方法，其包括提供有效量的药物组合物; 并将所述组合物与所述A型流感病毒WSN病毒接触，其中所述药物组合物含有C-藻蓝蛋白（C-PC），别藻蓝蛋白（APC）和螺旋藻生长因子（SGF）。 本发明还提供了一种提取所述药物组合物的方法，包括以下步骤：（a）向有机蓝绿藻粉中加入低渗缓冲溶液并充分混合; （b）将混合物在室温下孵育过夜; （c）通过离心机分离和纯化混合物; （d）收集悬浮的上清液并用光谱仪进行检测以确定成分和含量; 和（e）将上清液喷雾干燥; 其特征在于采用低温提取来维持药物组合物的生物活性和营养物质。

    Anti-enterovirus compounds
    9.
    发明授权
    Anti-enterovirus compounds 失效
    抗肠道病毒化合物

    公开(公告)号：US06815444B2

    公开(公告)日：2004-11-09

    申请号：US10444747

    申请日：2003-05-23

    申请人： Jyh-Haur Chern ,  Kak-Shan Shia ,  Shin-Ru Shih ,  Tsu-An Hsu ,  Chia-Liang Tai

    发明人： Jyh-Haur Chern ,  Kak-Shan Shia ,  Shin-Ru Shih ,  Tsu-An Hsu ,  Chia-Liang Tai

    IPC分类号： C07D48704

    CPC分类号： C07D487/04

    摘要： This invention features, among others, a pyrazolopyrimidine compound of formula (A): A is (CH2)q—CHRaRb; each of R1 and R2, independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R1 and R2 taken together is (CH2)r; each of R3 and R4, independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R5, Ra, and Rb, independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR′, SR, S(O)R, S(O)OR, NRR′, NR(O)CR′, NRC(O)OR′, or NRC(O)NR′R″; each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R′, and R″, independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4.

    摘要翻译： 本发明特别地包括式（A）的吡唑并嘧啶化合物：A是（CH 2）q-CHR a R b; R 1和R 2各自独立地是氢，卤素，氰基，硝基或烷基; 或者R 1和R 2一起是（CH 2）r; R 3和R 4各自独立地是氢，卤素，氰基，硝基或烷基; 氰基，硝基，烷基，芳基，芳烷基，杂芳基，OR，O（O）CR，R 3，R 3和R 4各自独立地是芳基，芳烷基或杂芳基， C（O）OR，NR（O）OR，C（O）NRR'，SR，S（O）R，S（O）OR，NRR' 或NRC（O）NR'R“; m，n，o，p和r各自独立地为0或1，q为0,1或2; 其中R，R'和R“各自独立地是氢或烷基，条件是m，n，o和p的和为1,2,3或4。

    PHARMACEUTICAL COMPOSITION FOR INHIBITING INFECTION AND REPLICATION OF INFLUENZA A AND B VIRUS, AND THE MANUFACTURE THEREOF
    10.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR INHIBITING INFECTION AND REPLICATION OF INFLUENZA A AND B VIRUS, AND THE MANUFACTURE THEREOF 有权
    用于抑制感染和复制流感病毒A和B病毒的药物组合物及其制造方法

    公开(公告)号：US20120121744A1

    公开(公告)日：2012-05-17

    申请号：US13167453

    申请日：2011-06-23

    申请人： Chuang-Chun CHIUH ,  Shin-Ru SHIH ,  Shau-Feng CHANG ,  Yi-Hsiang CHEN ,  I-Chen HU

    发明人： Chuang-Chun CHIUH ,  Shin-Ru SHIH ,  Shau-Feng CHANG ,  Yi-Hsiang CHEN ,  I-Chen HU

    IPC分类号： A61K35/74 ,  A61P31/16 ,  C12N1/20

    CPC分类号： C12N1/12 ,  A61K35/748 ,  C12N1/04

    摘要： Disclosed is a pharmaceutical composition for inhibiting infection and replication of influenza A and B virus, and the manufacture thereof. The pharmaceutical composition is produced by a manufacture of low-temperature disintegrating cyanobacteria, comprising the steps of: (a) mixing cyanobacteria and non-organic solvent to form a suspension containing cyanobacteria; (b) freezing the suspension with a temperature below 0° C. to form a ice block and the ice block being melted at a low temperature, the whole step being repeated at least twice; (c) separating the cyanobacterial residues and extract solution of the suspension; and (d) collecting the isolated cyanobacterial extract solution; wherein the cyanobacterial extract solution is a solution containing cyanobacterial bioactive substances. The pharmaceutical composition is able to effectively inhibit binding of sialic acid and hemagglutinin of influenza A and/or B virus, so as to inhibit infection and replication of influenza virus. Further, this pharmaceutical composition is able to inhibit infection of influenza virus resistant to neuraminidase inhibitors.

    摘要翻译： 公开了用于抑制A型和B型流感病毒感染和复制的药物组合物及其制造方法。 药物组合物是通过低温崩解蓝细菌的制造而制造的，包括以下步骤：（a）将蓝细菌和非有机溶剂混合以形成含有蓝细菌的悬浮液; （b）将温度低于0℃的悬浮液冷冻，形成冰块，冰块在低温下熔化，整个步骤重复至少两次; （c）分离悬浮液中的蓝藻残渣并提取溶液; 和（d）收集孤立的蓝藻提取物溶液; 其中蓝藻提取物溶液是含有蓝藻生物活性物质的溶液。 药物组合物能够有效抑制唾液酸和甲型流感病毒和/或B型病毒血凝素的结合，从而抑制流感病毒的感染和复制。 此外，该药物组合物能够抑制对神经氨酸酶抑制剂有抗性的流感病毒感染。