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    Insect larva aerosol infection method for producing recombinant proteins and baculovirus bio-insecticides
    7.
    发明授权
    Insect larva aerosol infection method for producing recombinant proteins and baculovirus bio-insecticides 失效
    昆虫幼虫气溶胶感染法生产重组蛋白和杆状病毒生物杀虫剂

    公开(公告)号：US07261886B2

    公开(公告)日：2007-08-28

    申请号：US10945898

    申请日：2004-09-22

    申请人： Tzong-Yuan Wu ,  Suey-Sheng Kao ,  Tzyy-Rong Jinn

    发明人： Tzong-Yuan Wu ,  Suey-Sheng Kao ,  Tzyy-Rong Jinn

    IPC分类号： A61K48/00 ,  C12N15/866 ,  A01N63/00

    CPC分类号： A01N63/00

    摘要： An insect larva aerosol infection method for producing recombinant proteins and baculovirus bio-insecticides is disclosed. A liquid spray of budded form baculoviruses are employed to infect insect larvae in order to reduce the manpower for manual injections and the energy wasted in feeding infection technologies. The invention may be applied to the production of recombinant proteins and baculoviruses as the production platform for bio-insecticides.

    摘要翻译： 公开了一种用于生产重组蛋白和杆状病毒生物杀虫剂的昆虫幼虫气溶胶感染方法。 使用芽状杆状病毒的液体喷雾感染昆虫幼虫，以减少手动注射的人力和在喂食感染技术中浪费的能量。 本发明可用于生产重组蛋白和杆状病毒作为生物杀虫剂的生产平台。

    Insect larva aerosol infection method for producing recombinant proteins and baculovirus bio-insecticides
    8.
    发明申请
    Insect larva aerosol infection method for producing recombinant proteins and baculovirus bio-insecticides 失效
    昆虫幼虫气溶胶感染法生产重组蛋白和杆状病毒生物杀虫剂

    公开(公告)号：US20050074432A1

    公开(公告)日：2005-04-07

    申请号：US10945898

    申请日：2004-09-22

    申请人： Tzong-Yuan Wu ,  Suey-Sheng Kao ,  Tzyy-Rong Jinn

    发明人： Tzong-Yuan Wu ,  Suey-Sheng Kao ,  Tzyy-Rong Jinn

    IPC分类号： A01N63/00 ,  A61K48/00

    CPC分类号： A01N63/00

    摘要： This specification discloses an insect larva aerosol infection method for producing recombinant proteins and baculovirus bio-insecticides. Liquid spray of budding form baculoviruses are employed to infect insect larvae to reduce the manpower for manual injections and energy waste in feeding infection technologies. The invention can be applied to the production of recombinant proteins and baculoviruses as the production platform for bio-insecticides.

    摘要翻译： 本说明书公开了一种用于生产重组蛋白和杆状病毒生物杀虫剂的昆虫幼虫气溶胶感染方法。 使用液体喷雾形式的杆状病毒感染昆虫幼虫，以减少人工注射和能量浪费在喂养感染技术方面的人力。 本发明可用于生产重组蛋白和杆状病毒作为生物杀虫剂的生产平台。

    Method for Inhibiting Cellular Na+-K+ ATPase Activity
    9.
    发明申请
    Method for Inhibiting Cellular Na+-K+ ATPase Activity 审中-公开
    抑制细胞Na + -K + ATP酶活性的方法

    公开(公告)号：US20070293462A1

    公开(公告)日：2007-12-20

    申请号：US11425133

    申请日：2006-06-19

    申请人： Tzyy-Rong Jinn ,  Yi-Ching Chen ,  Tze-Cheng Tzen

    发明人： Tzyy-Rong Jinn ,  Yi-Ching Chen ,  Tze-Cheng Tzen

    IPC分类号： A61K31/58 ,  A61K31/555

    CPC分类号： A61K31/555 ,  A61K31/58

    摘要： The present invention discloses an inhibitive effect of Na+-K+-ATPase caused by a compound selected from the group consisting of magnesium lithospermate B (MLB), isomer, prodrug, derivative, pharmaceutically acceptable salt, and a composition thereof. In this invention, the variations of Na+-K+-ATPase activity were monitored with increasing MLB concentrations, and the result shows the Na+-K+ ATPase activity is repressed by MLB. An outcome of the inhibitory effect, the function of cellular sodium/potassium lo exchanger is reduced and cellular calcium ion concentration is increased. That is, the MLB is useful for inhibiting the function of cellular Na+-K+ pump, and further brings the utility for cardiac stimulation, diuretic enhancement, heart failure curing, and so on.

    摘要翻译： 本发明公开了由选自以下的化合物引起的Na + -ATO -ATP -ATPase的抑制作用：镁铁氰菊酯B（MLB），异构体，前药， 衍生物，药学上可接受的盐及其组合物。 在本发明中，用增加的MLB浓度监测Na +→+ + + + - ATPase活性的变化，结果显示Na + ATP酶活性被MLB抑制。 抑制作用的结果，细胞钠/钾交换体的功能降低，细胞钙离子浓度增加。 也就是说，MLB可用于抑制细胞Na +的功能，并进一步带来心脏刺激，利尿增强，心力衰竭固化的效用， 等等。

    Method for Inhibiting Cellular Na+-K+ ATPase Activity
    10.
    发明申请
    Method for Inhibiting Cellular Na+-K+ ATPase Activity 审中-公开
    抑制细胞Na + -K + ATP酶活性的方法

    公开(公告)号：US20070293459A1

    公开(公告)日：2007-12-20

    申请号：US11551348

    申请日：2006-10-20

    申请人： Tzyy-Rong Jinn ,  Yi-Ching Chen ,  Tze-Cheng Tzen ,  Balance Chih-Ming Chen

    发明人： Tzyy-Rong Jinn ,  Yi-Ching Chen ,  Tze-Cheng Tzen ,  Balance Chih-Ming Chen

    IPC分类号： A61K31/58 ,  A61K31/555

    CPC分类号： A61K31/555 ,  A61K31/58

    摘要： The present invention discloses an inhibitive effect of Na+—K+-ATPase caused by a compound selected from the group consisting of magnesium lithospermate B (MLB), isomer, prodrug, derivative, pharmaceutically acceptable salt, and a composition thereof. In this invention, the variations of Na+—K+-ATPase activity were monitored with increasing MLB concentrations, and the result shows the Na+—K+ ATPase activity is repressed by MLB. An outcome of the inhibitory effect, the function of cellular sodium/potassium exchanger is reduced and cellular calcium ion concentration is increased. The cerebral ischemia test exhibited MLB provides an effective repression of cell infarct. That is, the MLB is useful for inhibiting the function of cellular Na+—K+ pump, and further brings the utility for cardiac stimulation, diuretic enhancement, heart failure curing, anti-anoxia, neurocyte apoptosis protection, apoplexy prevention and treatment, and so on.

    摘要翻译： 本发明公开了一种由选自以下的化合物引起的Na + -ATP -ATP酶的抑制作用：镁铁氰菊酯B（MLB），异构体，前药， 衍生物，药学上可接受的盐及其组合物。 在本发明中，用增加的MLB浓度监测Na +→+ + + + - ATPase活性的变化，结果显示Na + ATP酶活性被MLB抑制。 抑制作用的结果，细胞钠/钾交换剂的功能降低，细胞钙离子浓度增加。 脑缺血试验显示MLB提供有效的镇静细胞梗死。 也就是说，MLB可用于抑制细胞Na +的功能，并进一步带来心脏刺激，利尿增强，心力衰竭固化的效用， 抗缺氧，神经细胞凋亡保护，中风预防和治疗等。