公开(公告)号：US4935241A

公开(公告)日：1990-06-19

申请号：US266894

申请日：1988-11-03

申请人： Izumi Saitoh ,  Kaori Ikeda ,  Shigeru Kido ,  Yoshio Doi ,  Shohei Egawa

发明人： Izumi Saitoh ,  Kaori Ikeda ,  Shigeru Kido ,  Yoshio Doi ,  Shohei Egawa

IPC分类号： A61K9/70 ,  A61K31/415 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61P17/00

CPC分类号： A61K31/415 ,  A61K47/32 ,  A61K47/38 ,  A61K9/0014 ,  Y10S514/858 ,  Y10S514/964

摘要： A pharmaceutical preparation for the treatment of tinea pedis, containing as basic components about 0.1% to about 2.5% of croconazole hydrochloride and about 1%-15% of an ethyl acrylate-methyl methacrylate copolymer in an aqueous alcohol, and if necessary, about 0.1% to about 2.5% of a thickening agent and/or a plasticizer.

公开(公告)号：US4923893A

公开(公告)日：1990-05-08

申请号：US267284

申请日：1988-11-04

申请人： Izumi Saitoh ,  Shigeru Kido ,  Yoshio Doi ,  Shohei Egawa

发明人： Izumi Saitoh ,  Shigeru Kido ,  Yoshio Doi ,  Shohei Egawa

IPC分类号： A61K8/30 ,  A61K8/34 ,  A61K8/67 ,  A61K8/73 ,  A61K9/06 ,  A61K9/70 ,  A61K31/19 ,  A61K31/355 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38 ,  A61P3/02 ,  A61P29/00

CPC分类号： A61K31/355 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38 ,  A61K9/0014 ,  A61K9/7015 ,  Y10S514/887

摘要： External preparations consisting essentially of about 0.1% to about 5% of tocopherol acetate and/or about 0.05% to about 0.3% of glycyrrhetinic acid, about 1% to about 15% of a methacrylic acid-ethyl acrylate copolymer, and about 0.2% to about 3% of a thickening agent in an alcoholic solvent, wherein said copolymer is characterized by that the monomer ratio of ethyl acrylate to methacrylic acid is within a range from 75/25 to 95/5, with residual monomer being 50 ppm or less and with practically no surfactants.

公开(公告)号：US4915940A

公开(公告)日：1990-04-10

申请号：US271304

申请日：1988-11-15

申请人： Izumi Saitoh ,  Kaori Ikeda ,  Yoshio Doi ,  Shohei Egawa

发明人： Izumi Saitoh ,  Kaori Ikeda ,  Yoshio Doi ,  Shohei Egawa

IPC分类号： A61K9/70 ,  A61K31/27 ,  A61P31/04 ,  A61P31/10

CPC分类号： A61K31/27 ,  A61K9/7015

摘要： Film-formation-type antifungal preparations for external application, consisting essentially of about 0.1% to about 1.5% of tolnaphtate, about 10% to about 20% of a dimethylaminoethyl methacrylate-methacrylic acid ester copolymer and 0.5% to about 10% of a medium chain fatty acid ester in an alcoholic solvent but containing practically no water.

公开(公告)号：US4775667A

公开(公告)日：1988-10-04

申请号：US911151

申请日：1986-09-24

申请人： Izumi Saitoh ,  Hirokuni Jyoyama ,  Fujio Asanuma ,  Katsumi Hirose ,  Shohei Egawa

发明人： Izumi Saitoh ,  Hirokuni Jyoyama ,  Fujio Asanuma ,  Katsumi Hirose ,  Shohei Egawa

IPC分类号： A61K31/045 ,  A61K9/08 ,  A61K9/12 ,  A61K9/70 ,  A61K31/57 ,  A61K31/60 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  A61K31/605

CPC分类号： A61K9/12

摘要： Topical analgesic anti-inflammatory compositions containing a corticosteroid in addition to the conventional efficacy-proven ingredients are disclosed. They may be embodied in an aerosol, a solution and any other type of composition being convenient for administration. More than the sum of effects of the individual ingredients has been proved. In other words, the effects of the salicylate esters and L-menthol are synergistically enhanced by the addition of the corticosteroid. Particularly, the persistency of the analgesic/anti-inflammatory effects of the conventional ingredients has been proved to be dependent upon the the concentration of the corticosteroid in the composition.

摘要翻译： 公开了除常规有效验证的成分之外含有皮质类固醇的局部止痛抗炎组合物。 它们可以以气溶胶，溶液和任何其它类型的组合物来实施，其方便施用。 超过了各种成分的影响总和已被证明。 换句话说，水杨酸酯和L-薄荷醇的作用通过添加皮质类固醇协同增强。 特别地，常规成分的镇痛/抗炎作用的持续性已被证明取决于组合物中皮质类固醇的浓度。