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公开(公告)号：US20080131473A1
公开(公告)日：2008-06-05
申请号：US11631288
申请日：2005-07-05
申请人： Robert Brown , Showan Nazhat , Vivek Mudera , Mike Wiseman
发明人： Robert Brown , Showan Nazhat , Vivek Mudera , Mike Wiseman
摘要： This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organised biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibres of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
摘要翻译： 本发明涉及模拟细胞生物重建和产生具有适合用作功能性组织植入物的机械性质和活细胞密度的有组织生物材料的细胞非依赖性过程。 生物材料通过提供包含支架纤维基质和间质液的凝胶来生产; 并且塑性地压实凝胶以产生生物材料。 生物材料可以包括3D结构，例如模拟天然组织结构的细胞和基质的分层，比对和中尺度区带异质性。 具有本文所述的仿生结构的生物材料可用于一系列治疗应用。
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公开(公告)号：US09101693B2
公开(公告)日：2015-08-11
申请号：US11631288
申请日：2005-07-05
申请人： Robert Brown , Showan Nazhat , Vivek Mudera , Mike Wiseman
发明人： Robert Brown , Showan Nazhat , Vivek Mudera , Mike Wiseman
摘要： This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organized biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibers of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
摘要翻译： 本发明涉及模拟细胞生物重建和产生具有适合用作功能性组织植入物的机械性质和活细胞密度的有组织生物材料的细胞非依赖性过程。 生物材料通过提供包含支架纤维基质和间质液的凝胶来生产; 并且塑性地压实凝胶以产生生物材料。 生物材料可以包括3D结构，例如模拟天然组织结构的细胞和基质的分层，比对和中尺度区带异质性。 具有本文所述的仿生结构的生物材料可用于一系列治疗应用。
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