公开(公告)号：US20120076808A1

公开(公告)日：2012-03-29

申请号：US13245930

申请日：2011-09-27

Applicant: Bin WANG ,  Shuang GENG ,  Jin JIN

Inventor： Bin WANG ,  Shuang GENG ,  Jin JIN

IPC: A61K39/00 ,  A61P37/00 ,  A61P37/08 ,  A61P11/06 ,  A61P21/04 ,  A61P25/00 ,  A61P9/10 ,  A61P29/00 ,  A61P5/14 ,  A61K39/35 ,  A61P3/10

CPC classification number: A61K39/35 ,  A61K39/0008 ,  A61K2039/53

Abstract: The present invention relates to treating and preventing symptoms of an allergy, asthma, an autoimmune disease, and transplant rejection using a combination vaccine containing an antigen and a DNA encoding the antigen.

Abstract translation: 本发明涉及使用含有抗原和编码抗原的DNA的组合疫苗来治疗和预防过敏症，哮喘，自身免疫性疾病和移植排斥的症状。

公开(公告)号：US10206997B2

公开(公告)日：2019-02-19

申请号：US14356414

申请日：2011-11-10

Applicant: Bin Wang ,  Shuang Geng

Inventor： Bin Wang ,  Shuang Geng

IPC: A61K31/195 ,  A61K31/20 ,  A61K31/30 ,  A61K31/7004 ,  A61K36/05 ,  A61K39/29 ,  A61K9/00 ,  A61K39/39 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

Abstract: Provided herein is a vaccine that combines a vaccine facilitator and a DNA construct encoding an antigen to elicit antigen-specific antibody responses, wherein the vaccine facilitator is a Na/K pump inhibitor. Cellular entry of the DNA is accelerated as compared to other vaccines that do not contain the vaccine facilitator.

公开(公告)号：US20150004194A1

公开(公告)日：2015-01-01

申请号：US14356414

申请日：2011-11-10

Applicant: Bin Wang ,  Shuang Geng

Inventor： Bin Wang ,  Shuang Geng

IPC: A61K39/29 ,  A61K9/00 ,  C12N7/00 ,  A61K39/39

CPC classification number: A61K39/292 ,  A61K9/0009 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/57 ,  A61K2039/572 ,  C12N7/00 ,  C12N2710/00034 ,  C12N2730/10134

Abstract: Provided herein is a vaccine that combines a vaccine facilitator and a DNA construct encoding an antigen to elicit antigen-specific antibody responses, wherein the vaccine facilitator is a Na/K pump inhibitor. Cellular entry of the DNA is accelerated as compared to other vaccines that do not contain the vaccine facilitator.

Abstract translation: 本文提供了将疫苗促进剂和编码抗原的DNA构建体结合以引发抗原特异性抗体应答的疫苗，其中所述疫苗促进剂是Na / K泵抑制剂。 与不含疫苗促进剂的其他疫苗相比，DNA的细胞进入加速。