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公开(公告)号：US20090306424A1
公开(公告)日：2009-12-10
申请号：US12540138
申请日：2009-08-12
IPC分类号： C07C227/14
CPC分类号： C07C227/08 , C07C229/22
摘要： The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.
摘要翻译： 本发明涉及通过在合适的烷基化剂和碱的存在下发生的羧甲基化反应制备式（I）化合物的方法，而不需要监测反应环境的pH。 式（I）化合物是制备用于MRI技术的诊断造影剂的有用中间体。
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公开(公告)号：US07592482B2
公开(公告)日：2009-09-22
申请号：US11991763
申请日：2006-08-24
IPC分类号： C07C229/00
CPC分类号： C07C227/08 , C07C229/22
摘要： The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.
摘要翻译： 本发明涉及通过在合适的烷基化剂和碱的存在下发生的羧甲基化反应制备式（I）化合物的方法，而不需要监测反应环境的pH。 式（I）化合物是制备用于MRI技术的诊断造影剂的有用中间体。
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公开(公告)号：US08624061B2
公开(公告)日：2014-01-07
申请号：US13127804
申请日：2009-11-02
IPC分类号： C07C233/67
CPC分类号： C07C231/02 , C07C237/46
摘要： The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more details, the invention discloses a process for the preparation of a compound of formula (III) comprising the condensation reaction a compound of formula (II) with 2-amino-1,3-propandiol, being said reaction carried out in an aprotic dipolar solvent and in the presence of an alkaline or alkaline rare earth metal oxide or hydroxide.
摘要翻译： 本发明依赖于制备非离子碘化造影剂的方法，更具体地说，本发明涉及以高产率和高纯度制备伊波帕醇的方法。 更详细地说，本发明公开了一种制备式（III）化合物的方法，其包括式（II）化合物与2-氨基-1,3-丙二醇的缩合反应，所述反应是以非质子 在碱性或碱性稀土金属氧化物或氢氧化物的存在下进行。
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公开(公告)号：US20090118537A1
公开(公告)日：2009-05-07
申请号：US11991763
申请日：2006-08-24
IPC分类号： C07C227/18
CPC分类号： C07C227/08 , C07C229/22
摘要： The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.
摘要翻译： 本发明涉及通过在合适的烷基化剂和碱的存在下发生的羧甲基化反应制备式（I）化合物的方法，而不需要监测反应环境的pH。 式（I）化合物是制备用于MRI技术的诊断造影剂的有用中间体。
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5.发明申请Process for the Preparation of Gadobenate Dimeglumine Complex in a Solid Form 审中-公开以固体形式制备钆酸二甲酚复合物的方法公开(公告)号：US20120232151A1
公开(公告)日：2012-09-13
申请号：US13510409
申请日：2010-11-23
申请人： Pier Lucio Anelli , Pierfrancesco Morisini , Silvia Ceragioli , Fulvio Uggeri , Luciano Lattuada , Roberta Fretta , Aurelia Ferrigato
发明人： Pier Lucio Anelli , Pierfrancesco Morisini , Silvia Ceragioli , Fulvio Uggeri , Luciano Lattuada , Roberta Fretta , Aurelia Ferrigato
IPC分类号： C07C227/00 , A61K31/197 , C07C229/36
CPC分类号： A61K49/1887 , A61K9/0019 , B29C67/24 , C07C213/10 , C07C227/38 , C07C227/40 , Y10T428/2982 , C07C229/22
摘要： The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.
摘要翻译： 本发明公开了一种以固体形式制备钆酸二甲酚络合物的方法。 特别地，所述固体形式通过在给定温度和浓度下喷雾干燥相应的液体悬浮液而方便地得到。 本发明对于工业规模是特别有利的，因为固体形式可以通过使用水作为溶剂，其是无毒溶剂，易于处理并且基本上不需要麻烦的健康或安全预防措施来获得。
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公开(公告)号：US20110207960A1
公开(公告)日：2011-08-25
申请号：US13127804
申请日：2009-11-02
IPC分类号： C07C259/06 , C07C231/02 , C07C231/10
CPC分类号： C07C231/02 , C07C237/46
摘要： The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more details, the invention discloses a process for the preparation of a compound of formula (III) comprising the 5 condensation reaction a compound of formula (II) with 2-amino-1,3-propandiol, being said reaction carried out in an aprotic dipolar solvent and in the presence of an alkaline or alkaline rare earth metal oxide or hydroxide.
摘要翻译： 本发明依赖于制备非离子碘化造影剂的方法，更具体地说，本发明涉及以高产率和高纯度制备伊波帕醇的方法。 更详细地说，本发明公开了一种制备式（III）化合物的方法，包括式（II）化合物与2-氨基-1,3-丙二醇的缩合反应，所述反应是在 非质子偶极溶剂和碱性或碱性稀土金属氧化物或氢氧化物存在下进行。
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