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公开(公告)号：US20090032592A1
公开(公告)日：2009-02-05
申请号：US12160306
申请日：2007-01-11
CPC分类号： C40B60/02 , B01J19/0046 , B01J2219/00416 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00565 , B01J2219/00567 , G01N2035/00574 , G01N2035/00782 , Y10T428/2989 , Y10T428/2998
摘要： The present application discloses a composition comprising a plurality of spherical beads, wherein a radiofrequency chip operating at a frequency of in the range of 2.2-2.7 GHz is embedded within each of said beads and wherein essentially each of said beads is individually identifiable on the basis of radiofrequency identification. Alternatives utilizing a ultrasonic identification chip are also disclosed. The beads are preferably made of polymeric material and can for example be used for the synthesis of e.g. solid-phase chemical libraries. Preferred materials include some that minimise interference in biochemical assays (fouling). The invention also relates to batch and continuous methods of producing such compositions, including emulsion-polymerisation methods. In a further aspect, the present invention relates to an apparatus for analysing radiofrequency-encoded beads. Also provided are methods for detecting and/or analysing and/or sorting beads, as well as methods for processing beads once they have been analysed and/or sorted.
摘要翻译： 本申请公开了一种包含多个球形珠粒的组合物，其中以2.2-2.7GHz的频率工作的射频芯片嵌入每个所述珠粒内，并且其中基本上每个所述珠粒可以基于 的射频识别。 还公开了利用超声波识别芯片的替代方案。 珠粒优选由聚合物材料制成，例如可用于合成例如聚合物。 固相化学文库。 优选的材料包括使生物化学测定（结垢）中的干扰最小化的一些。 本发明还涉及制备这种组合物的分批和连续方法，包括乳液聚合方法。 在另一方面，本发明涉及用于分析射频编码的珠的装置。 还提供了用于检测和/或分析和/或分选珠粒的方法，以及一旦分析和/或分选珠粒的方法。
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公开(公告)号：US08791053B2
公开(公告)日：2014-07-29
申请号：US10529397
申请日：2003-09-26
申请人： Soren Flygenring Christensen , Jens Hog Truelsen , Morten Meldal , Roice Michael , Ib Johannsen
发明人： Soren Flygenring Christensen , Jens Hog Truelsen , Morten Meldal , Roice Michael , Ib Johannsen
CPC分类号： B01J19/0046 , B01J2219/005 , B01J2219/0054 , B01J2219/00551 , B01J2219/00576 , B01J2219/00585 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/0074
摘要： The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilized particles. The spatial immobilization of the particles confers on each beaded polymer matrix a “fingerprint” which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices.
摘要翻译： 本发明涉及用于组合固相合成，测定，功能蛋白质组学和诊断用途的珠粒或颗粒形式的空间编码聚合物基质。 还提供了这种珠粒或颗粒的组合物。 组合物的每个串珠聚合物基质包含多个空间固定的颗粒。 颗粒的空间固定赋予每个珠光聚合物基质上的“指纹”，其使得能够鉴定珠粒群体中独特的珠粒。 单个珠的独特鉴定使得在记录单个化学转化的同时执行组合化学策略成为可能。 还提供了用于检测颗粒空间中的相对位置的方法，用于生成矩阵的方法，用于距离矩阵确定的方法，用于识别各个矩阵的方法以及用于记录和存储矩阵的图像的设备。
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公开(公告)号：US20120132572A1
公开(公告)日：2012-05-31
申请号：US13353141
申请日：2012-01-18
CPC分类号： C40B60/02 , B01J19/0046 , B01J2219/00416 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00565 , B01J2219/00567 , G01N2035/00574 , G01N2035/00782 , Y10T428/2989 , Y10T428/2998
摘要： The present application discloses spherical polymer bead comprising embedded therein an ultrasonic identification chip, said chip comprising one or more resonator cavities, the dimensions of each of the one or more resonator cavities giving rise to an ultrasonic resonance frequency of 20 kHz or more. The application also discloses a bead sorting apparatus equipped with at least one ultrasonic transmitter and at least one ultrasonic receiver, and a method of measuring the ultrasonic code of an ultrasonic encoded bead using the bead sorting apparatus.
摘要翻译： 本申请公开了包含嵌入超声波识别芯片的球形聚合物珠，所述芯片包括一个或多个谐振腔，所述一个或多个谐振腔中的每一个的尺寸产生20kHz或更大的超声共振频率。 本申请还公开了一种配备有至少一个超声波发射器和至少一个超声波接收器的珠粒分选装置，以及使用珠粒分选装置测量超声编码珠粒的超声波码的方法。
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