公开(公告)号：US20180231541A1

公开(公告)日：2018-08-16

申请号：US15890932

申请日：2018-02-07

Applicant: Hycor Biomedical, LLC

Inventor： Mark Van Cleve ,  Taylor Reid ,  Gerold Firl ,  Yohei Yamamuro ,  Nathaniel Hague

IPC: G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N1/38 ,  G01N35/10

CPC classification number: G01N33/54333 ,  B01L3/0227 ,  B01L3/0237 ,  B01L3/5082 ,  B01L2300/12 ,  B01L2400/043 ,  G01N1/38 ,  G01N35/0098 ,  G01N35/025 ,  G01N35/10 ,  G01N35/1081 ,  G01N2001/386 ,  G01N2035/00534 ,  G01N2035/00574 ,  G01N2035/1058

Abstract: In an embodiment, an immunochemistry analysing system includes a source of paramagnetic particles, a source of fluid, a cuvette configured to receive the paramagnetic particles and the fluid, a pipette configured to (i) translate so that at least a portion of the pipette is located within the cuvette and (ii) dispense at least one of the paramagnetic particles and the fluid into the cuvette so that the paramagnetic particles and the fluid can be mixed within the cuvette, a motor configured to move the pipette while located in the cuvette, and a control unit configured to vary a motor drive of the motor to cause the pipette to mix the fluid with the paramagnetic particles within the cuvette.

公开(公告)号：US09695467B2

公开(公告)日：2017-07-04

申请号：US14553151

申请日：2014-11-25

Applicant: Roche Molecular Systems, Inc.

Inventor： Reto Keller ,  Thomas Meyer

IPC: C12Q1/68 ,  B01L7/00 ,  B01L9/00 ,  B03C1/28 ,  G01N35/00

CPC classification number: C12Q1/6806 ,  B01L7/52 ,  B01L9/523 ,  B01L2200/0668 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1844 ,  B03C1/288 ,  G01N35/0098 ,  G01N2035/00574 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device magnetically separates the particles. The heating and separating devices move into at least one operative position for processing the fluids and at least one inoperative position with respect to the containers, in which the containers are kept stationary at least during and in-between incubating the fluids and manipulating the magnetically responsive particles.

公开(公告)号：US20170165662A1

公开(公告)日：2017-06-15

申请号：US15214091

申请日：2016-07-19

Applicant: Dynex Technologies, Inc.

Inventor： Adrian Bunce ,  Andrew Fusellier

IPC: B01L3/00

CPC classification number: B01L3/5085 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00662 ,  B01L2200/0668 ,  B01L2300/0829 ,  G01N33/54366 ,  G01N35/1081 ,  G01N2035/00574 ,  G01N2035/1086

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.

公开(公告)号：US09523701B2

公开(公告)日：2016-12-20

申请号：US13187791

申请日：2011-07-21

Applicant: Adrian Bunce ,  Andrew Fusellier

Inventor： Adrian Bunce ,  Andrew Fusellier

IPC: G01N33/543 ,  G01N35/10 ,  B01L3/00 ,  G01N35/00

CPC classification number: B01L3/5085 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00662 ,  B01L2200/0668 ,  B01L2300/0829 ,  G01N33/54366 ,  G01N35/1081 ,  G01N2035/00574 ,  G01N2035/1086

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.

Abstract translation: 公开了一种包含样品阱的样品板。 样品孔可以包括一个或多个珠保留室。 还公开了使用样品板的方法和包括样品板的试剂盒。

公开(公告)号：US09244069B2

公开(公告)日：2016-01-26

申请号：US13463507

申请日：2012-05-03

Applicant: Adrian Bunce ,  Andrew Fusellier

Inventor： Adrian Bunce ,  Andrew Fusellier

IPC: G01N33/543 ,  B01L3/00 ,  G01N35/10 ,  G01N33/53 ,  G01N35/00

CPC classification number: G01N33/54393 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01L3/5085 ,  B01L2200/0668 ,  B01L2300/0829 ,  G01N33/5304 ,  G01N35/1065 ,  G01N35/1083 ,  G01N2035/00574 ,  G01N2035/1086

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

公开(公告)号：US20150050726A1

公开(公告)日：2015-02-19

申请号：US14525976

申请日：2014-10-28

Applicant: LUMINEX CORPORATION

Inventor： Steve Jia Chang YU ,  Jesus CHING ,  Phillip You Fai LEE ,  David Hsiang HU

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  B01F15/0237 ,  B01L3/502 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/523 ,  B01L3/527 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/0609 ,  B01L2300/0672 ,  B01L2300/18 ,  B01L2400/0478 ,  C12N15/1013 ,  G01N35/00871 ,  G01N35/0098 ,  G01N35/026 ,  G01N35/028 ,  G01N35/04 ,  G01N35/08 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00544 ,  G01N2035/00574 ,  G01N2035/00801 ,  G01N2035/00811 ,  G01N2035/00881 ,  G01N2035/0091 ,  G01N2035/0412 ,  G01N2035/0415 ,  Y10S436/807 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/25

Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.

Abstract translation: 描述了用于处理样本的并行处理系统。 在一个实施例中，并行处理系统包括用于控制托盘电机驱动系统的仪器接口并行控制器，闭环加热器控制和检测系统，磁性粒子传递系统，试剂释放系统，试剂预混泵送系统 和洗涤缓冲液泵送系统。

公开(公告)号：US20140335627A1

公开(公告)日：2014-11-13

申请号：US14268682

申请日：2014-05-02

Applicant: Cepheid

Inventor： RONALD CHANG ,  Douglas B. Dority ,  Steven Montgomery

IPC: B01L3/00

CPC classification number: B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

Abstract translation: 本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。 在一些实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。 该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。 剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。 覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠 。

公开(公告)号：US20130115712A1

公开(公告)日：2013-05-09

申请号：US13459469

申请日：2012-04-30

Applicant: Steve Jia Chang Yu ,  Jesus Ching ,  Phillip You Fai Lee ,  David Hsiang Hu

Inventor： Steve Jia Chang Yu ,  Jesus Ching ,  Phillip You Fai Lee ,  David Hsiang Hu

IPC: G01N21/62

CPC classification number: C12Q1/6806 ,  B01F15/0237 ,  B01L3/502 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/523 ,  B01L3/527 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/0609 ,  B01L2300/0672 ,  B01L2300/18 ,  B01L2400/0478 ,  C12N15/1013 ,  G01N35/00871 ,  G01N35/0098 ,  G01N35/026 ,  G01N35/028 ,  G01N35/04 ,  G01N35/08 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00544 ,  G01N2035/00574 ,  G01N2035/00801 ,  G01N2035/00811 ,  G01N2035/00881 ,  G01N2035/0091 ,  G01N2035/0412 ,  G01N2035/0415 ,  Y10S436/807 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/25

Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.

公开(公告)号：US08409531B2

公开(公告)日：2013-04-02

申请号：US12512926

申请日：2009-07-30

Applicant: Ronald Chang ,  Douglas B. Dority ,  Steve Montgomery

Inventor： Ronald Chang ,  Douglas B. Dority ,  Steve Montgomery

IPC: B01L3/00 ,  G01N31/00 ,  G01N33/543 ,  B65G47/14 ,  B23Q7/04 ,  B65H3/06 ,  B65H3/24 ,  B65H3/44 ,  B65H1/08 ,  B65H3/00 ,  G01N1/00 ,  G07F9/00 ,  G07F11/16 ,  B65G59/00

CPC classification number: B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

Abstract translation: 本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。 在一些实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。 该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。 剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。 覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠 。

公开(公告)号：US08254696B2

公开(公告)日：2012-08-28

申请号：US12044927

申请日：2008-03-07

Applicant: Joseph Matteoni ,  Jeffery P. Bertram ,  Wayne K. Moore ,  Daniel B. Nickell

Inventor： Joseph Matteoni ,  Jeffery P. Bertram ,  Wayne K. Moore ,  Daniel B. Nickell

IPC: G06K9/62

CPC classification number: G01N1/2214 ,  G01N1/2273 ,  G01N15/1475 ,  G01N35/0098 ,  G01N2001/2223 ,  G01N2015/0088 ,  G01N2035/00574

Abstract: A method is provided for detection of an airborne contaminant in a atmospheric environment. The method comprises capturing an air sample from the atmospheric environment; separating candidate particles of interest from particles of non interest in the air sample; generating an image of the candidate particles; identifying a contaminant from among the candidate particles by comparing the image of candidate particles with a plurality of stored reference images, each of which reflects a respective identified contaminant; and notifying a remote third party in response to detecting a contaminant from among the candidate particles.

Abstract translation: 提供了一种用于在大气环境中检测空气污染物的方法。 该方法包括从大气环境捕获空气样品; 将所关注的候选颗粒与空气样品中不感兴趣的颗粒分离; 产生候选粒子的图像; 通过将候选粒子的图像与多个存储的参考图像进行比较来识别候选粒子中的污染物，每个参考图像反映相应的识别的污染物; 以及响应于检测到所述候选粒子中的污染物而通知远程第三方。