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    Methods and computer system for combinatorial analysis of lighting phosphors
    1.
    发明授权
    Methods and computer system for combinatorial analysis of lighting phosphors 失效
    照明荧光粉组合分析方法与计算机系统

    公开(公告)号：US06567751B1

    公开(公告)日：2003-05-20

    申请号：US09704475

    申请日：2000-11-03

    申请人： Xiao-Dong Sun

    发明人： Xiao-Dong Sun

    IPC分类号： G06F1900

    CPC分类号： C40B20/08 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00351 ,  B01J2219/00373 ,  B01J2219/00378 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00695 ,  B01J2219/00745 ,  C40B40/18 ,  C40B60/02

    摘要： There is disclosed a method and a computer system enabling high-throughput combinatorial synthesis and screening of lighting phosphors. The system links hardware instrumentation for synthesis and screening. It records, sorts, and analyzes photo-metric data gathered from the combinatorial studies, along with the characteristics of the combinatory processes. The system provides a database as the data storage and query engine, an analysis module as the processor for analytical operations, and an interface for accepting the user's input and displaying the analysis results and other information requested by the user.

    摘要翻译： 公开了一种实现高通量组合合成和照明荧光体筛选的方法和计算机系统。 该系统链接硬件仪器进行综合和筛选。 它记录，分类和分析从组合研究中收集的光度数据，以及组合过程的特征。 该系统提供数据库作为数据存储和查询引擎，作为分析操作的处理器的分析模块，以及用于接受用户输入并显示用户请求的分析结果和其他信息的界面。

    METHODS AND DEVICES FOR MULTIPLEXED MICROARRAY MICROFLUIDIC ANALYSIS OF BIOMOLECULES
    3.
    发明申请
    METHODS AND DEVICES FOR MULTIPLEXED MICROARRAY MICROFLUIDIC ANALYSIS OF BIOMOLECULES 有权
    生物分子多重微量微流控分析方法与装置

    公开(公告)号：US20130053273A1

    公开(公告)日：2013-02-28

    申请号：US13597362

    申请日：2012-08-29

    申请人： David Juncker ,  Huiyan Li

    发明人： David Juncker ,  Huiyan Li

    IPC分类号： C40B30/04 ,  C40B50/08 ,  C40B60/14

    CPC分类号： C40B60/02 ,  B01J2219/00382 ,  B01J2219/00533 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L3/5088 ,  B01L3/563 ,  B01L2200/0642 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/0822 ,  C40B20/02 ,  G01N33/54366 ,  G01N33/6845

    摘要： Rapid and specific detection of biological cells and biomolecules is important to biological assays across diverse fields including genomics, proteomics, diagnoses, and pathological studies. Microarrays and microfluidics increasingly dominate such detection techniques due to the ability to perform significant numbers of tests with limited sample volumes. A snap chip assembly is provided for the transfer of a microarray of reagents within semi-spherical liquid droplets on a transfer chip to a target assay microarray on an assay chip following assembly of the two chips and physical contact of the droplets with the target array. Reagents in nanolitre quantities are spotted on both chips and selectively transferred as liquid droplets between transfer chip and assay chip within the contact areas. Using the snap chip structure the inventors performed immunoassays with colocalization of capture and detection antibodies with 10 targets and bead-in-gel droplet microarrays with 9 targets in the low pg/ml regime.

    摘要翻译： 生物细胞和生物分子的快速和特异性检测对于包括基因组学，蛋白质组学，诊断和病理学研究在内的不同领域的生物测定是重要的。 由于能够以有限的样品量执行大量测试，因此微阵列和微流体学越来越多地主导这种检测技术。 提供了一种快速芯片组件，用于在组装两个芯片之后将微球阵列的转移芯片上的半球形液滴转移到测定芯片上的靶分析微阵列上，并将液滴与靶阵列物理接触。 在两个芯片上都发现纳米级的试剂，并在接触区域内作为转移芯片和测定芯片之间的液滴选择性地转移。 使用快速芯片结构，本发明人使用具有10个靶的凝胶捕获和检测抗体进行免疫测定，并在低pg / ml方案中用9个靶标进行珠凝胶液滴微阵列。

    Methods and devices for multiplexed microarray microfluidic analysis of biomolecules
    4.
    发明授权
    Methods and devices for multiplexed microarray microfluidic analysis of biomolecules 有权
    生物分子多重微阵列微流体分析的方法和装置

    公开(公告)号：US09481945B2

    公开(公告)日：2016-11-01

    申请号：US13597362

    申请日：2012-08-29

    申请人： David Juncker ,  Huiyan Li

    发明人： David Juncker ,  Huiyan Li

    IPC分类号： C40B60/02 ,  G01N33/543 ,  G01N33/68 ,  C40B20/02 ,  B01L3/00

    CPC分类号： C40B60/02 ,  B01J2219/00382 ,  B01J2219/00533 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L3/5088 ,  B01L3/563 ,  B01L2200/0642 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/0822 ,  C40B20/02 ,  G01N33/54366 ,  G01N33/6845

    摘要： Rapid and specific detection of biological cells and biomolecules is important to biological assays across diverse fields including genomics, proteomics, diagnoses, and pathological studies. Microarrays and microfluidics increasingly dominate such detection techniques due to the ability to perform significant numbers of tests with limited sample volumes. A snap chip assembly is provided for the transfer of a microarray of reagents within semi-spherical liquid droplets on a transfer chip to a target assay microarray on an assay chip following assembly of the two chips and physical contact of the droplets with the target array. Reagents in nanoliter quantities are spotted on both chips and selectively transferred as liquid droplets between transfer chip and assay chip within the contact areas. Using the snap chip structure the inventors performed immunoassays with colocalization of capture and detection antibodies with 10 targets and bead-in-gel droplet microarrays with 9 targets in the low pg/ml regime.

    摘要翻译： 生物细胞和生物分子的快速和特异性检测对于包括基因组学，蛋白质组学，诊断和病理学研究在内的不同领域的生物测定是重要的。 由于能够以有限的样品量执行大量测试，因此微阵列和微流体学越来越多地主导这种检测技术。 提供了一种快速芯片组件，用于在组装两个芯片之后将微球阵列的转移芯片上的半球形液滴转移到测定芯片上的靶分析微阵列上，并将液滴与靶阵列物理接触。 在两个芯片上都发现纳升量的试剂，并在接触区域内作为转移芯片和测定芯片之间的液滴选择性地转移。 使用快速芯片结构，本发明人使用具有10个靶的凝胶捕获和检测抗体进行免疫测定，并在低pg / ml方案中用9个靶标进行珠凝胶液滴微阵列。

    SPHERICAL ENCODED BEADS
    5.
    发明申请
    SPHERICAL ENCODED BEADS 审中-公开
    球形编织珠

    公开(公告)号：US20120132572A1

    公开(公告)日：2012-05-31

    申请号：US13353141

    申请日：2012-01-18

    申请人： Soren Flygenring CHRISTENSEN

    发明人： Soren Flygenring CHRISTENSEN

    IPC分类号： B07C5/34 ,  B32B27/04

    CPC分类号： C40B60/02 ,  B01J19/0046 ,  B01J2219/00416 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00565 ,  B01J2219/00567 ,  G01N2035/00574 ,  G01N2035/00782 ,  Y10T428/2989 ,  Y10T428/2998

    摘要： The present application discloses spherical polymer bead comprising embedded therein an ultrasonic identification chip, said chip comprising one or more resonator cavities, the dimensions of each of the one or more resonator cavities giving rise to an ultrasonic resonance frequency of 20 kHz or more. The application also discloses a bead sorting apparatus equipped with at least one ultrasonic transmitter and at least one ultrasonic receiver, and a method of measuring the ultrasonic code of an ultrasonic encoded bead using the bead sorting apparatus.

    摘要翻译： 本申请公开了包含嵌入超声波识别芯片的球形聚合物珠，所述芯片包括一个或多个谐振腔，所述一个或多个谐振腔中的每一个的尺寸产生20kHz或更大的超声共振频率。 本申请还公开了一种配备有至少一个超声波发射器和至少一个超声波接收器的珠粒分选装置，以及使用珠粒分选装置测量超声编码珠粒的超声波码的方法。

    Investigating different physical and/or chemical forms of materials
    8.
    发明申请
    Investigating different physical and/or chemical forms of materials 审中-公开
    调查材料的不同物理和/或化学形式

    公开(公告)号：US20060129329A1

    公开(公告)日：2006-06-15

    申请号：US11280980

    申请日：2005-11-15

    申请人： Ryszard Kobylecki ,  Daniel Cowell ,  Vassilis Stylianopoulos

    发明人： Ryszard Kobylecki ,  Daniel Cowell ,  Vassilis Stylianopoulos

    IPC分类号： G06F19/00

    CPC分类号： G01N35/028 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00364 ,  B01J2219/00423 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00704 ,  B01J2219/00756 ,  C40B60/02

    摘要： A method is provided for investigating different physical and/or chemical forms of a material. The material is placed in an array of receptacles. The material in different receptacles is subjected to different treatments under the control of a computer. Any material resulting from the different treatments is then analyzed. The treatments and the resultant material may be suitably associated. An apparatus used in this method provides an array of receptacles into which the material may be placed. The apparatus includes means for treating the material in the receptacles, for example by heating with a heater block, cooling with a cooling coil, and agitation by a stirrer block. The apparatus includes a computer to control the respective different treatments to the material in the different receptacles. The receptacles may optionally include a porous member that is porous to fluids but not the initial material.

    摘要翻译： 提供了一种用于调查材料的不同物理和/或化学形式的方法。 材料放置在一个插座阵列中。 不同容器中的材料在计算机的控制下进行不同的处理。 然后分析由不同处理产生的任何材料。 处理和所得材料可以适当地相关联。 在该方法中使用的装置提供了可以放置材料的容器阵列。 该设备包括用于处理容器中的材料的装置，例如通过用加热器块加热，用冷却盘管冷却和通过搅拌块搅拌。 该装置包括计算机，用于控制对不同容器中的材料的各种不同处理。 容器可以可选地包括对流体是多孔的但不是初始材料的多孔构件。

    SPHERICAL ENCODED BEADS
    10.
    发明申请
    SPHERICAL ENCODED BEADS 审中-公开
    球形编织珠

    公开(公告)号：US20090032592A1

    公开(公告)日：2009-02-05

    申请号：US12160306

    申请日：2007-01-11

    申请人： Soren Flygenring Christensen

    发明人： Soren Flygenring Christensen

    IPC分类号： G06K7/01 ,  B32B27/04 ,  B05D3/10

    CPC分类号： C40B60/02 ,  B01J19/0046 ,  B01J2219/00416 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00565 ,  B01J2219/00567 ,  G01N2035/00574 ,  G01N2035/00782 ,  Y10T428/2989 ,  Y10T428/2998

    摘要： The present application discloses a composition comprising a plurality of spherical beads, wherein a radiofrequency chip operating at a frequency of in the range of 2.2-2.7 GHz is embedded within each of said beads and wherein essentially each of said beads is individually identifiable on the basis of radiofrequency identification. Alternatives utilizing a ultrasonic identification chip are also disclosed. The beads are preferably made of polymeric material and can for example be used for the synthesis of e.g. solid-phase chemical libraries. Preferred materials include some that minimise interference in biochemical assays (fouling). The invention also relates to batch and continuous methods of producing such compositions, including emulsion-polymerisation methods. In a further aspect, the present invention relates to an apparatus for analysing radiofrequency-encoded beads. Also provided are methods for detecting and/or analysing and/or sorting beads, as well as methods for processing beads once they have been analysed and/or sorted.

    摘要翻译： 本申请公开了一种包含多个球形珠粒的组合物，其中以2.2-2.7GHz的频率工作的射频芯片嵌入每个所述珠粒内，并且其中基本上每个所述珠粒可以基于 的射频识别。 还公开了利用超声波识别芯片的替代方案。 珠粒优选由聚合物材料制成，例如可用于合成例如聚合物。 固相化学文库。 优选的材料包括使生物化学测定（结垢）中的干扰最小化的一些。 本发明还涉及制备这种组合物的分批和连续方法，包括乳液聚合方法。 在另一方面，本发明涉及用于分析射频编码的珠的装置。 还提供了用于检测和/或分析和/或分选珠粒的方法，以及一旦分析和/或分选珠粒的方法。