公开(公告)号：US06558904B2

公开(公告)日：2003-05-06

申请号：US09355443

申请日：1999-07-28

申请人： Eugen Ermantraut ,  Johann Michael Köhler ,  Torsten Schulz ,  Klaus Wohlfart ,  Stefan Wölfl

发明人： Eugen Ermantraut ,  Johann Michael Köhler ,  Torsten Schulz ,  Klaus Wohlfart ,  Stefan Wölfl

IPC分类号： C12P1934

CPC分类号： B82Y30/00 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/0043 ,  B01J2219/00527 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00725 ,  B01J2219/00731 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/047 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G03F7/00

摘要： The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded substance libraries. To this end, a) a substrate (2) suitable for the first monolayer is provided; b) a microstructured polymer mask (1) having openings is applied to the subtrate (2) at least once in a defined direction. Said polymer mask (1) is sufficiently thin and flexible for it to adhere to the substrate (2) by adhesion, and the material selected for the polymer mask (1) is chemically stable; c) the sandwich constituted by the substrate (2) and polymer mask (1) is flooded with a first agent corresponding to the intended use, so as to create at least one first molecular monolayer in the areas defined by the mask openings; c1) depending on the monolayer structure to be created step c) is repeated using the first agent or one or more additional agents; and d) after carrying out the step described in c) or the steps described in c) and c1), the polymer mask is pulled off after modification of the substrate surface areas which were left uncovered by the mask openings and were subjected to the agent or agents.

摘要翻译： 本发明涉及一种用于生产各种分子物质的结构化，自组织分子单层的方法。 本发明优选用于产生固相键合物质文库。 为此，提供a）适合于第一单层的基底（2） b）具有开口的微结构化聚合物掩模（1）在限定的方向上至少一次施加到该脱墨剂（2）。 所述聚合物掩模（1）足够薄并且柔性以使其通过粘附粘附到基底（2），并且选择用于聚合物掩模（1）的材料是化学稳定的; c）由基材（2）和聚合物掩模（1）构成的夹层用与预期用途相对应的第一试剂浸没，以便在由掩模开口限定的区域中产生至少一个第一分子单层; c1）取决于要产生的单层结构步骤c）使用第一试剂或一种或多种另外的试剂重复; 和d）在执行c）或c）和c1）中描述的步骤之后，在修改未被掩模开口未被覆盖的基材表面区域并经受试剂之后，将聚合物掩模拉离 或代理。

公开(公告)号：US06821692B1

公开(公告)日：2004-11-23

申请号：US09230975

申请日：1999-02-04

申请人： Eugen Ermantraut ,  Johann Michael Köhler ,  Torsten Schulz ,  Klaus Wohlfart ,  Stefan Wölfl

发明人： Eugen Ermantraut ,  Johann Michael Köhler ,  Torsten Schulz ,  Klaus Wohlfart ,  Stefan Wölfl

IPC分类号： G03F7023

CPC分类号： H01L21/02118 ,  B01J19/0046 ,  B01J2219/00527 ,  C12Q1/002 ,  H01L21/02282 ,  H01L21/312

摘要： The present invention relates to novel thin layers for microsystem techniques and microstructuring. It is an object of the invention to provide thin layers which can be manufactured under less problems and more economically than the previous conventional layers, and which permit the use of existing technologies for microstructuring. The object is realized in that the thin layer is formed of an enzymatically degradable biopolymer in a range of layer thicknesses of from 30 nm to 3 &mgr;m. Biopolymeric thin layers manufactured according to the invention permit their application, after a respective structurizing, as test assays or in setting up substance libraries.

摘要翻译： 本发明涉及用于微系统技术和微结构化的新型薄层。 本发明的一个目的是提供薄层，其可以在比以前的常规层更少的问题和更经济地制造，并且允许使用现有的技术来进行微结构化。 实现目的在于，薄层由层压厚度为30nm至3μm范围内的可酶促降解的生物聚合物形成。 根据本发明生产的生物聚合物薄层允许其在各自的结构化之后作为测试测定或在建立物质文库中的应用。