公开(公告)号：US20190192739A1

公开(公告)日：2019-06-27

申请号：US16326326

申请日：2017-09-19

Applicant: Olga BAKER ,  Kihoon NAM ,  Pedro LEI ,  Stelios ANDREADIS ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Olga Baker ,  Kihoon Nam ,  Pedro Lei ,  Stelios Andreadis

IPC: A61L27/52 ,  C07K19/00 ,  C07K14/78 ,  A61L27/22

CPC classification number: A61L27/52 ,  A61K47/64 ,  A61L27/225 ,  A61L2430/22 ,  A61L2430/40 ,  C07K14/75 ,  C07K14/78 ,  C07K19/00 ,  C07K2319/50 ,  C07K2319/60

Abstract: The invention is directed to a composition comprising a fibrin hydrogel conjugated to peptides of laminin-111 (L1) and methods for repairing damaged salivary tissue using the composition.

公开(公告)号：US20070081983A1

公开(公告)日：2007-04-12

申请号：US11523474

申请日：2006-09-19

Applicant: Stelios Andreadis ,  Jin Liu

Inventor： Stelios Andreadis ,  Jin Liu

IPC: A61K48/00 ,  C12Q1/00 ,  C12N5/08

CPC classification number: C12N5/0691 ,  A61K35/12 ,  A61K48/00 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/56 ,  C12N5/0692 ,  C12N2510/00 ,  C12N2533/56 ,  C08L89/00

Abstract: The present invention is directed to a method of isolating smooth muscle cells or progenitors thereof from a mixed population of cells. A preparation of isolated smooth muscle cells or progenitors thereof, where the smooth muscle cells or progenitors thereof constitute at least 90% of the preparation, is also disclosed. The present invention is also directed to a method of producing a tissue-engineered vascular vessel containing the preparation of isolated smooth muscle cells or progenitors thereof. The resulting tissue-engineered vascular vessel and a method of producing a tissue-engineered vascular vessel for a particular patient are also disclosed.

Abstract translation: 本发明涉及从混合细胞群中分离平滑肌细胞或其祖细胞的方法。 还公开了分离的平滑肌细胞或其祖细胞的制备物，其中平滑肌细胞或其祖细胞构成至少90％的制剂。 本发明还涉及一种生产包含分离的平滑肌细胞或其祖细胞的制备的组织工程化血管的方法。 还公开了所得到的组织工程化血管容器以及为特定患者制备组织工程化血管的方法。