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公开(公告)号：US6124929A
公开(公告)日：2000-09-26
申请号：US135765
申请日：1998-08-18
申请人： Stephen C. Weibel
发明人： Stephen C. Weibel
IPC分类号： G01B9/02
CPC分类号： G01J3/4535 , G01J3/021
摘要： A Michelson interferometer includes a beamsplitter onto which an input light beam is directed. The beamsplitter divides the input light beam into a first beam portion incident upon a first fixed reflector and a second beam portion incident upon a movable retroreflector. The movable retroreflector reflects the second beam onto another fixed reflector and then back to the beamsplitter where the first and second beams are combined and directed to a detector. The movable retroreflector is attached to one end of a rotating arm moving at a constant angular velocity. The retroreflector reflects the second beam at a fixed location in its orbital path. The angular velocity of the retroreflector and rotating arm combination may be varied over a wide range to provide a large modulated frequency bandwidth. The operating duty cycle of the interferometer may be doubled by attaching a second retroreflector to the other end of the rotating arm, with the weights of the two retroreflectors counterbalancing each other. The interferometer's optical alignment is insensitive to angular tilt and lateral shear (horizontal and vertical translation) of the interferometer's scanning element.
摘要翻译： 迈克尔逊干涉仪包括一个输入光束被引导到的分束器。 分束器将输入光束分成入射在第一固定反射器上的第一光束部分和入射到可移动后向反射器上的第二光束部分。 可移动后向反射器将第二光束反射到另一个固定的反射器上，然后返回到分束器，其中第一和第二光束被组合并被引导到检测器。 可移动后向反射器附接到以恒定角速度移动的旋转臂的一端。 后向反射器将第二光束反射到其轨道中的固定位置。 后向反射器和旋转臂组合的角速度可以在宽范围内变化以提供大的调制频率带宽。 通过将第二后向反射器附接到旋转臂的另一端，干涉仪的工作占空比可以加倍，两个逆反射器的重量彼此平衡。 干涉仪的光学对准对干涉仪扫描元件的角度倾斜和横向剪切（水平和垂直平移）不敏感。
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公开(公告)号：US07576863B2
公开(公告)日：2009-08-18
申请号：US12018518
申请日：2008-01-23
申请人： Stephen C. Weibel
发明人： Stephen C. Weibel
IPC分类号： G01N21/00
CPC分类号： G01N21/553
摘要： Disclosed is a horizontal SPR sensor apparatus that provides a simplified beam path, ease of sample handling with concomitant ease of analysis. The horizontal SPR device disclosed herein includes an input and output transfer mirror pair that translates vertically along an axis perpendicular to the beam path. The invention includes an input/output scanner mirror pair that is operatively linked to the transfer mirror pair. This allows for rotation of the scanner mirror pair in response to the vertical translation of the transfer mirror pair and maintains the incident light focus on the metal film/sample layer while varying the angle of incidence and thereby exciting the surface plasmon resonance at the thin metal film layer. Further, this allows the detector and detector optics to be fixed providing for the implementation of heavier multi-stage cooled detectors. Finally, the invention provides an SPR device having a smaller footprint than known alternatives.
摘要翻译： 公开了一种水平SPR传感器装置，其提供简化的光束路径，便于样品处理，同时易于分析。 本文公开的水平SPR装置包括沿垂直于光束路径的轴线垂直平移的输入和输出传送镜对。 本发明包括可操作地连接到传送镜对的输入/输出扫描器镜对。 这允许响应于转移镜对的垂直平移来扫描器反射镜对的旋转，并且将入射光聚焦保持在金属膜/样品层上，同时改变入射角，从而激发在薄金属处的表面等离子体共振 电影层。 此外，这允许检测器和检测器光学器件被固定，从而实现较重的多级冷却检测器。 最后，本发明提供了具有比已知替代物更小的占地面积的SPR装置。
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3.发明授权公开(公告)号：US06330062B1
公开(公告)日：2001-12-11
申请号：US09303260
申请日：1999-04-30
IPC分类号： G01N2155
CPC分类号： G01N21/35 , G01N21/359 , G01N21/553
摘要： Adsorption of molecules onto a thin metallic surface such as of gold, silver or copper is measured by surface plasmon resonance (SPR) using Fourier Transform (FT) spectroscopy. Reflectance spectra from a prism/metallic film sample surface at a fixed angle of incidence is measured with FT spectroscopy. The reflectance spectrum exhibits a pronounced minimum due to the SPR effect, which can be shifted by changing the angle of incidence or metallic film thickness. The position of the reflectance minimum shifts in wavelength with the adsorption of molecules onto the gold surface due to a change in the index of refraction at the interface. The FT-SPR sensor instrument provides wavelength stability and reproducibility of the resonance wavelength to permit detection of small wavelength shifts, and also substantially increases the spectral range over which the SPR measurements can be made. A beam of broadband radiation from a Michelson interferometer is directed through an SPR sample cell and onto a detector where the output signal is processed using standard FT techniques.
摘要翻译： 使用傅立叶变换（FT）光谱法，通过表面等离子体共振（SPR）测量分子到金，银或铜等金属表面上的吸附。 用FT光谱法测量来自固定入射角的棱镜/金属膜样品表面的反射光谱。 由于SPR效应，反射光谱显示出明显的最小值，可通过改变入射角或金属膜厚度来移动反射光谱。 由于界面处的折射率的变化，反射率最小值的位置随着分子吸附在金表面上而波长的偏移。 FT-SPR传感器仪器提供了波长稳定性和谐振波长的再现性，以允许检测小的波长位移，并且还大大提高可以进行SPR测量的光谱范围。 来自迈克尔逊干涉仪的宽带辐射波束通过SPR采样单元引导到检测器上，其中使用标准FT技术处理输出信号。
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公开(公告)号：US5406090A
公开(公告)日：1995-04-11
申请号：US20522
申请日：1993-02-22
CPC分类号： H01K1/02 , G01J3/108 , G01J3/4535 , H01K7/00
摘要： An interferometer including a beamsplitter and fixed and movable cube corner reflectors is adapted for use in a Fourier-transform infrared (FTIR) spectrometer. The spectrometer includes a cast metal base, such as of aluminum, with the interferometer including an IR source housing formed integrally with the base for dissipating heat via conduction. The IR source housing is hollow and open at the top for receiving a removable opaque printed circuit board (PCB) which is coupled to and provides support for and electrical current to an IR source within the housing. The housing includes two apertures in lateral portions thereof. An IR beam is directed by the source through a first aperture to the Michelson interferometer, while a second aperture is adapted to receive a fiber optic light guide to allow for direct viewing of the IR source in a safe manner without removing the PCB cover of the housing. An interferometer chamber is isolated from a sample chamber, both of which chambers may be independently purged and are further isolated from the spectrometer's electronic circuitry. The spectrometer includes a minimum number of reflectors outside of the interferometer for reduced light loss and improved signal-to-noise ratio with the interferometer providing an output IR beam to a first focus mirror which horizontally focuses the beam on and directs the beam through the sample and thence onto a second focus mirror which vertically focuses the beam on a closely spaced IR detector integrated in a printed circuit board.
摘要翻译： 包括分束器和固定和可移动立体角反射器的干涉仪适用于傅里叶变换红外（FTIR）光谱仪。 光谱仪包括诸如铝的铸造金属基底，干涉仪包括与基座一体形成的IR源壳体，用于通过导电散热。 IR源壳体是中空的并且在顶部开口用于接收可移除的不透明印刷电路板（PCB），其被连接到壳体内并且向壳体内的IR源提供支撑和电流。 壳体的侧部包括两个孔。 红外光束由源通过第一孔引导到迈克尔逊干涉仪，而第二孔适于接收光纤光导，以允许以安全的方式直接观察IR源，而不需要移除 住房。 干涉仪室与样品室隔离，这两个室可独立地清洗，并与光谱仪的电子电路进一步隔离。 光谱仪包括在干涉仪外部的最少数量的反射器，用于降低光损耗并提高信噪比，干涉仪提供输出IR光束到第一聚焦反射镜，水平聚焦光束并引导光束通过样品 然后进入第二聚焦镜，其将光束垂直地聚焦在集成在印刷电路板中的紧密间隔的IR检测器上。
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公开(公告)号：US20080198383A1
公开(公告)日：2008-08-21
申请号：US12018518
申请日：2008-01-23
申请人： Stephen C. Weibel
发明人： Stephen C. Weibel
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： Disclosed is a horizontal SPR sensor apparatus that provides a simplified beam path, ease of sample handling with concomitant ease of analysis. The horizontal SPR device disclosed herein includes an input and output transfer mirror pair that translates vertically along an axis perpendicular to the beam path. The invention includes an input/output scanner mirror pair that is operatively linked to the transfer mirror pair. This allows for rotation of the scanner mirror pair in response to the vertical translation of the transfer mirror pair and maintains the incident light focus on the metal film/sample layer while varying the angle of incidence and thereby exciting the surface plasmon resonance at the thin metal film layer. Further, this allows the detector and detector optics to be fixed providing for the implementation of heavier multi-stage cooled detectors. Finally, the invention provides an SPR device having a smaller footprint than known alternatives.
摘要翻译： 公开了一种水平SPR传感器装置，其提供简化的光束路径，便于样品处理，同时易于分析。 本文公开的水平SPR装置包括沿垂直于光束路径的轴线垂直平移的输入和输出传送镜对。 本发明包括可操作地连接到传送镜对的输入/输出扫描器镜对。 这允许响应于转移镜对的垂直平移来扫描器反射镜对的旋转，并且将入射光聚焦保持在金属膜/样品层上，同时改变入射角，从而激发在薄金属处的表面等离子体共振 电影层。 此外，这允许检测器和检测器光学器件被固定，从而实现较重的多级冷却检测器。 最后，本发明提供了具有比已知替代物更小的占地面积的SPR装置。
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