公开(公告)号：US07226791B2

公开(公告)日：2007-06-05

申请号：US10858367

申请日：2004-06-01

申请人： Julie Carman ,  Stephen J. Warner ,  Rolf-Peter Ryseck

发明人： Julie Carman ,  Stephen J. Warner ,  Rolf-Peter Ryseck

IPC分类号： C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12Q1/68 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention provides polynucleotides encoding human and murine guanylate binding protein polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The present invention further relates to diagnostic and therapeutic methods for applying the guanylate binding protein polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as rheumatoid arthritis and/or conditions related to aberrant NF-κB activity, guanylate binding activity and GTPase activity. The present invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码人和鼠鸟苷酸结合蛋白多肽的多核苷酸，其片段和同系物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及用于将鸟苷酸结合蛋白多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法，所述疾病和/或病症例如类风湿性关节炎和/或与异常相关的病症 NF-κB活性，鸟苷酸结合活性和GTPase活性。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。