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1.发明授权Oral compositions of fenretinide having increased bioavailability and methods of using the same 有权具有增加的生物利用度的芬维A胺的口服组合物及其使用方法公开(公告)号：US07785621B2
公开(公告)日：2010-08-31
申请号：US10767352
申请日：2004-01-30
申请人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
发明人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
CPC分类号： A61K9/0095 , A23L33/10 , A23V2002/00 , A61K9/1617 , A61K9/1664 , A61K31/167 , A23V2250/30 , A23V2250/186 , A23V2250/192 , A23V2250/1846
摘要： The present invention provides an edible composition for oral delivery of an active agent such as a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.
摘要翻译： 本发明提供了用于口服递送活性剂如视黄酸盐的可食用组合物。 组合物包含干燥可流动粉末的形式：（a）活性剂如视黄酸盐; （b）脂质基质组成; （c）任选的甜味剂; （d）面粉。 本发明的组合物本身可以施用或与固体或液体食品载体混合，由受试者或给药通过饲管直接口服消费。
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公开(公告)号：US07407779B2
公开(公告)日：2008-08-05
申请号：US10492252
申请日：2002-10-11
IPC分类号： C12P19/26 , C12P19/44 , C12P13/00 , C12P7/64 , A61K31/739
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A 2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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3.发明申请Oral compositions having increased bioavailability and methods of using the same 审中-公开具有增加的生物利用度的口服组合物及其使用方法公开(公告)号：US20050271707A1
公开(公告)日：2005-12-08
申请号：US11170371
申请日：2005-06-29
申请人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
发明人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
IPC分类号： A23L1/30 , A61K9/00 , A61K31/167 , A61K47/00 , A61K31/337
CPC分类号： A61K9/0095 , A23L33/10 , A23V2002/00 , A61K9/1617 , A61K9/1664 , A61K31/167 , A23V2250/30 , A23V2250/186 , A23V2250/192 , A23V2250/1846
摘要： The present invention provides an edible composition for oral delivery of an active agent such as paclitaxel or a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.
摘要翻译： 本发明提供了用于口服递送活性剂如紫杉醇或视黄酸盐的可食用组合物。 组合物包含干燥可流动粉末的形式：（a）活性剂如视黄酸盐; （b）脂质基质组成; （c）任选的甜味剂; （d）面粉。 本发明的组合物本身可以施用或与固体或液体食品载体混合，由受试者或给药通过饲管直接口服消费。
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公开(公告)号：US20110190238A1
公开(公告)日：2011-08-04
申请号：US13087738
申请日：2011-04-15
IPC分类号： A61K31/662 , A61P11/00
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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公开(公告)号：US07780978B2
公开(公告)日：2010-08-24
申请号：US11170561
申请日：2005-06-29
申请人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
发明人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
CPC分类号： A61K9/0095 , A23L33/10 , A23V2002/00 , A61K9/1617 , A61K9/1664 , A61K31/167 , A23V2250/30 , A23V2250/186 , A23V2250/192 , A23V2250/1846
摘要： The present invention provides an edible composition for oral delivery of an active agent such as paclitaxel or a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.
摘要翻译： 本发明提供了用于口服递送活性剂如紫杉醇或视黄酸盐的可食用组合物。 组合物包含干燥可流动粉末的形式：（a）活性剂如视黄酸盐; （b）脂质基质组成; （c）任选的甜味剂; （d）面粉。 本发明的组合物本身可以施用或与固体或液体食品载体混合，由受试者或给药通过饲管直接口服消费。
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6.发明授权Cationic polymers for nucleic acid transfection and bioactive agent delivery 失效用于核酸转染和生物活性剂递送的阳离子聚合物
公开(公告)号：US5948878A
公开(公告)日：1999-09-07
申请号：US842555
申请日：1997-04-15
申请人： Stephen W. Burgess , Walter A. Shaw
发明人： Stephen W. Burgess , Walter A. Shaw
CPC分类号： A61K47/48207 , A61K47/48192 , A61K47/484 , A61K48/00 , C12N15/87
摘要： A class of polycationic polymers comprising products obtained by the copolymerization of a diprimary amine and a suitable comonomer, wherein the diprimary amine contains at least two primary amines and at least two secondary amines, and their use for nucleic acid transfection, and the delivery of suitable anionically charged bioactive molecules.
摘要翻译： 一类聚阳离子聚合物，其包含通过二原子胺和合适的共聚单体的共聚获得的产物，其中二原子胺含有至少两个伯胺和至少两个仲胺，以及它们用于核酸转染的用途， 阴离子带电的生物活性分子。
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公开(公告)号：US08222233B2
公开(公告)日：2012-07-17
申请号：US13087738
申请日：2011-04-15
IPC分类号： A61K31/662 , A61K47/12 , A61K9/00 , A61P11/00
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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公开(公告)号：US07992093B2
公开(公告)日：2011-08-02
申请号：US11066687
申请日：2005-02-25
申请人： Andrew R. Osborn , Charles K. Cowham , Sarah L. Brown , Stephen H. Briers , Stephen W. Burgess , Alan P. Newson , Kyle M. Rhodes
发明人： Andrew R. Osborn , Charles K. Cowham , Sarah L. Brown , Stephen H. Briers , Stephen W. Burgess , Alan P. Newson , Kyle M. Rhodes
CPC分类号： G05B19/0426 , G05B2219/23258 , G06F8/34
摘要： Various methods of programming a processing system utilizing a computer having a configuration canvas, at least one processor, and a plurality of function objects is disclosed. A processing configuration is created by placing object icons associated with function objects onto the canvas. Execution paths are automatically routed between the object icons based on orientations of icons on the canvas. Data flow paths are created between object icons on the canvas separately from the routings of the execution paths. Execution paths can be re-routed to increase the versatility of the processing system. Also, visual instruments and instrument icons can be utilized to further graphically illustrate and control the processing configuration.
摘要翻译： 公开了利用具有配置画布，至少一个处理器和多个功能对象的计算机对处理系统进行编程的各种方法。 通过将与功能对象相关联的对象图标放置在画布上来创建处理配置。 基于画布上的图标的方向，执行路径在对象图标之间自动路由。 在执行路径的路由上分别在画布上的对象图标之间创建数据流路径。 可以重新路由执行路径，以增加处理系统的多功能性。 此外，可以利用视觉仪器和仪器图标来进一步图形地说明和控制处理配置。
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公开(公告)号：US20120283218A1
公开(公告)日：2012-11-08
申请号：US13547306
申请日：2012-07-12
IPC分类号： A61K47/44 , A61P43/00 , A61K31/685
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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公开(公告)号：US07947306B2
公开(公告)日：2011-05-24
申请号：US12142370
申请日：2008-06-19
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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