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公开(公告)号：US20120283218A1
公开(公告)日：2012-11-08
申请号：US13547306
申请日：2012-07-12
IPC分类号： A61K47/44 , A61P43/00 , A61K31/685
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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公开(公告)号：US08222233B2
公开(公告)日：2012-07-17
申请号：US13087738
申请日：2011-04-15
IPC分类号： A61K31/662 , A61K47/12 , A61K9/00 , A61P11/00
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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公开(公告)号：US20110190238A1
公开(公告)日：2011-08-04
申请号：US13087738
申请日：2011-04-15
IPC分类号： A61K31/662 , A61P11/00
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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公开(公告)号：US07780978B2
公开(公告)日：2010-08-24
申请号：US11170561
申请日：2005-06-29
申请人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
发明人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
CPC分类号： A61K9/0095 , A23L33/10 , A23V2002/00 , A61K9/1617 , A61K9/1664 , A61K31/167 , A23V2250/30 , A23V2250/186 , A23V2250/192 , A23V2250/1846
摘要： The present invention provides an edible composition for oral delivery of an active agent such as paclitaxel or a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.
摘要翻译： 本发明提供了用于口服递送活性剂如紫杉醇或视黄酸盐的可食用组合物。 组合物包含干燥可流动粉末的形式：（a）活性剂如视黄酸盐; （b）脂质基质组成; （c）任选的甜味剂; （d）面粉。 本发明的组合物本身可以施用或与固体或液体食品载体混合，由受试者或给药通过饲管直接口服消费。
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公开(公告)号：US07947306B2
公开(公告)日：2011-05-24
申请号：US12142370
申请日：2008-06-19
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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公开(公告)号：US20090017119A1
公开(公告)日：2009-01-15
申请号：US12142370
申请日：2008-06-19
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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7.发明授权Oral compositions of fenretinide having increased bioavailability and methods of using the same 有权具有增加的生物利用度的芬维A胺的口服组合物及其使用方法公开(公告)号：US07785621B2
公开(公告)日：2010-08-31
申请号：US10767352
申请日：2004-01-30
申请人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
发明人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
CPC分类号： A61K9/0095 , A23L33/10 , A23V2002/00 , A61K9/1617 , A61K9/1664 , A61K31/167 , A23V2250/30 , A23V2250/186 , A23V2250/192 , A23V2250/1846
摘要： The present invention provides an edible composition for oral delivery of an active agent such as a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.
摘要翻译： 本发明提供了用于口服递送活性剂如视黄酸盐的可食用组合物。 组合物包含干燥可流动粉末的形式：（a）活性剂如视黄酸盐; （b）脂质基质组成; （c）任选的甜味剂; （d）面粉。 本发明的组合物本身可以施用或与固体或液体食品载体混合，由受试者或给药通过饲管直接口服消费。
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公开(公告)号：US07407779B2
公开(公告)日：2008-08-05
申请号：US10492252
申请日：2002-10-11
IPC分类号： C12P19/26 , C12P19/44 , C12P13/00 , C12P7/64 , A61K31/739
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译： 提供了用磷脂酶A 2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。
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9.发明申请Oral compositions having increased bioavailability and methods of using the same 审中-公开具有增加的生物利用度的口服组合物及其使用方法公开(公告)号：US20050271707A1
公开(公告)日：2005-12-08
申请号：US11170371
申请日：2005-06-29
申请人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
发明人： Barry J. Maurer , Charles Patrick Reynolds , David W. Yesair , Robert Travis McKee , Stephen W. Burgess , Walter A. Shaw
IPC分类号： A23L1/30 , A61K9/00 , A61K31/167 , A61K47/00 , A61K31/337
CPC分类号： A61K9/0095 , A23L33/10 , A23V2002/00 , A61K9/1617 , A61K9/1664 , A61K31/167 , A23V2250/30 , A23V2250/186 , A23V2250/192 , A23V2250/1846
摘要： The present invention provides an edible composition for oral delivery of an active agent such as paclitaxel or a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.
摘要翻译： 本发明提供了用于口服递送活性剂如紫杉醇或视黄酸盐的可食用组合物。 组合物包含干燥可流动粉末的形式：（a）活性剂如视黄酸盐; （b）脂质基质组成; （c）任选的甜味剂; （d）面粉。 本发明的组合物本身可以施用或与固体或液体食品载体混合，由受试者或给药通过饲管直接口服消费。
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10.发明授权Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories 失效用于输送药物或卡路里的混合脂质碳酸氢盐胶体颗粒
公开(公告)号：US5571517A
公开(公告)日：1996-11-05
申请号：US448878
申请日：1995-05-24
申请人： David W. Yesair
发明人： David W. Yesair
CPC分类号： A61K9/1075
摘要： A composition is disclosed containing nonesterified fatty acids having 14-18 carbon atoms, monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms, lysophosphatidylcholine in which the fatty acid moiety has 14-18 carbon atoms and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable fats and as particles for topical application to the skin. A method of making these particles is also described.
摘要翻译： 公开了一种组合物，其含有具有14-18个碳原子的非酯化脂肪酸，甘油单酯和具有14-18个碳原子的脂肪酸的单酸甘油酯，其中脂肪酸部分具有14-18个碳原子的溶血磷脂酰胆碱和碳酸氢盐。 组合物还可任选地含有胆汁盐。 这些组合物形成亚微米尺寸的胶体颗粒，并且可以作为运输口服药物，易于吸收的脂肪形式的卡路里来源和用于局部施用于皮肤的颗粒的载体。 还描述了制备这些颗粒的方法。
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