Method for the treatment of neurodegenerative diseases
    2.
    发明授权
    Method for the treatment of neurodegenerative diseases 有权
    治疗神经退行性疾病的方法

    公开(公告)号:US08435514B2

    公开(公告)日:2013-05-07

    申请号:US13132670

    申请日:2009-12-04

    IPC分类号: A61K39/395

    CPC分类号: C07K16/2878 A61K2039/505

    摘要: Disclosed are methods for treating neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Parkinson's Disease, Myasthenia Gravis, Multifocal Motor Neuropathy, Primary Lateral Sclerosis, Spinal Muscular Atrophy, Kennedy's Disease, and Spinocerebellar Ataxia, by administration of a compound that blocks the interaction of CD40 and CD40L.

    摘要翻译: 公开了通过施用阻断相互作用的化合物来治疗神经变性疾病如肌萎缩性侧索硬化症,阿尔茨海默病,帕金森病,重症肌无力,多焦点运动神经病,原发性侧索硬化,脊髓性肌萎缩,肯尼迪氏病和脊髓小脑共济失调的方法 的CD40和CD40L。

    Novelty caps for writing instruments
    6.
    发明申请
    Novelty caps for writing instruments 审中-公开
    书写工具的新奇帽子

    公开(公告)号:US20070020036A1

    公开(公告)日:2007-01-25

    申请号:US10557760

    申请日:2004-05-19

    申请人: Steven Perrin

    发明人: Steven Perrin

    IPC分类号: B43K23/12 B43K29/00

    CPC分类号: B43K23/08 B43K29/007

    摘要: A top for a writing instrument comprises a body of transparent material, an insert encapsulated within the body, and at least one display face defined by portions of the insert for displaying an image through the body to the exterior. The transparent material is advantageously a clear silicone rubber.

    摘要翻译: 用于书写工具的顶部包括透明材料的主体,封装在主体内的插入件以及由插入件的部分限定的至少一个显示面,用于通过主体向外部显示图像。 透明材料有利地是透明硅橡胶。

    Microarray-based subtractive hybridzation
    9.
    发明授权
    Microarray-based subtractive hybridzation 有权
    基于微阵列的消减杂交

    公开(公告)号:US06638717B2

    公开(公告)日:2003-10-28

    申请号:US09314698

    申请日:1999-05-19

    IPC分类号: C12Q168

    摘要: The present invention relates to a highly efficient, high-throughput method for the identification and elimination of redundancy in a population of nucleic acid molecules using microarrays. This method involves a reiterative subtraction protocol that creates a library that becomes more biased toward unknown genes with each successive round. The removal of repetitive and previously characterized nucleic acids from the library allows the identification of low-abundance mRNA from sources of interest and enhances the rate of novel gene discovery. The present invention is also useful for the removal of contaminating nucleic acids from cloning libraries.

    摘要翻译: 本发明涉及使用微阵列识别和消除核酸分子群体中的冗余的高效,高通量的方法。 该方法涉及重复的减法协议,其创建在每个连续轮次中变得更加偏向于未知基因的文库。 从文库中去除重复和先前表征的核酸允许从感兴趣来源鉴定低丰度mRNA,并增强新基因发现的速率。 本发明也可用于从克隆文库中除去污染性核酸。