公开(公告)号：US20100203055A1

公开(公告)日：2010-08-12

申请号：US12527694

申请日：2008-02-19

申请人： Toru Imamura ,  Miho Kimura ,  Mitsuko Kawano ,  Nozomi Tsujino ,  Akiko Kuramochi ,  Yuko Oda ,  Kaori Motomura ,  Masashi Suzuki ,  Masahiro Asada ,  Azusa Kameyama ,  Sumie Togayachi ,  Syuichi Oka

发明人： Toru Imamura ,  Miho Kimura ,  Mitsuko Kawano ,  Nozomi Tsujino ,  Akiko Kuramochi ,  Yuko Oda ,  Kaori Motomura ,  Masashi Suzuki ,  Masahiro Asada ,  Azusa Kameyama ,  Sumie Togayachi ,  Syuichi Oka

IPC分类号： A61K39/395 ,  A61K38/02 ,  A61K36/42 ,  A61K31/7088 ,  A61P17/14 ,  C12Q1/02

CPC分类号： A61K36/42 ,  A01K2227/105 ,  A61K8/64 ,  A61K8/97 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/1825 ,  A61K45/06 ,  A61K2800/70 ,  A61Q7/00

摘要： It is intended to provide a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia by determining an endogenous factor that inhibits hair growth and screening for substances that inhibit the activity or expression of the endogenous factor. It has been found that FGF18 inhibits hair growth. A method of screening for substances that inhibit the activity of FGF18 or substances that inhibit the expression of FGF18 to thereby obtain candidates for the hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia is disclosed. Also disclosed is a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia comprising, as an active ingredient(s), a substance that inhibit the activity of FGF18 and/or a substance that inhibits the expression of FGF18 such as a partial peptide of FGF18 or a Momordica charantia hot water extract.

摘要翻译： 旨在通过测定抑制毛发生长的内源因子和筛选抑制内源性因子的活性或表达的物质来提供毛发生长促进剂，毛发再生促进剂或脱发治疗剂。 已经发现FGF18抑制毛发生长。 公开了筛选抑制FGF18活性的物质或抑制FGF18表达的物质从而获得毛发生长促进剂，毛发再生促进剂或脱发治疗剂的候选物的方法。 还公开了一种毛发生长促进剂，头发再生促进剂或脱发治疗剂，其包含作为活性成分的抑制FGF18活性的物质和/或抑制FGF18表达的物质，例如部分 FGF18肽或苦瓜热水提取物。

公开(公告)号：US20100183733A1

公开(公告)日：2010-07-22

申请号：US12527693

申请日：2008-02-19

申请人： Toru Imamura ,  Miho Kimura ,  Mitsuko Kawano ,  Nazomi Tsujino ,  Akiko Kuramochi ,  Yuko Oda ,  Kaori Motomura ,  Masashi Suzuki ,  Masahiro Asada ,  Azusa Kameyama ,  Sumie Togayachi ,  Syuichi Oka

发明人： Toru Imamura ,  Miho Kimura ,  Mitsuko Kawano ,  Nazomi Tsujino ,  Akiko Kuramochi ,  Yuko Oda ,  Kaori Motomura ,  Masashi Suzuki ,  Masahiro Asada ,  Azusa Kameyama ,  Sumie Togayachi ,  Syuichi Oka

IPC分类号： A61K8/98 ,  C07K14/50 ,  A61K8/64 ,  A61Q9/04 ,  C12N15/63 ,  C12Q1/68

CPC分类号： C07K14/43536 ,  A61K8/64 ,  A61Q7/02 ,  G01N33/566 ,  G01N2333/50 ,  G01N2500/10

摘要： A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).

摘要翻译： 通过测定具有毛发生长抑制活性的内源性因子，筛选具有与内源因子相似的活性的物质或增强内源性因子的活性或表达的物质来提供脱毛剂或毛发生长抑制剂，以及 利用这些物质的生理活性。 已经发现FGF18抑制毛发生长。 公开了筛选FGF18样活性物质的方法，促进FGF18活性的物质或促进FGF18表达的物质，从​​而获得毛发生长抑制剂或脱毛剂的候选物。 还公开了一种毛发生长抑制剂或脱毛剂，其包含作为活性成分的FGF18和/或FGF18部分肽或FGF18样活性物质和/或促进FGF18活性或表达的物质（ 例如，Digenea单克隆提取物）。

公开(公告)号：US20120251455A1

公开(公告)日：2012-10-04

申请号：US13360419

申请日：2012-01-27

申请人： Toru IMAMURA ,  Miho KIMURA ,  Mitsuko KAWANO ,  Nozomi TSUJINO ,  Akiko KURAMOCHI ,  Yuko ODA ,  Kaori MOTOMURA ,  Masashi SUZUKI ,  Masahiro ASADA ,  Azusa KAMEYAMA ,  Sumie TOGAYACHI ,  Syuichi OKA

发明人： Toru IMAMURA ,  Miho KIMURA ,  Mitsuko KAWANO ,  Nozomi TSUJINO ,  Akiko KURAMOCHI ,  Yuko ODA ,  Kaori MOTOMURA ,  Masashi SUZUKI ,  Masahiro ASADA ,  Azusa KAMEYAMA ,  Sumie TOGAYACHI ,  Syuichi OKA

IPC分类号： C12Q1/68 ,  A61K49/00 ,  G01N33/566 ,  G01N21/25

CPC分类号： C07K14/43536 ,  A61K8/64 ,  A61Q7/02 ,  G01N33/566 ,  G01N2333/50 ,  G01N2500/10

摘要： A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).

摘要翻译： 通过测定具有毛发生长抑制活性的内源性因子，筛选具有与内源因子相似的活性的物质或增强内源性因子的活性或表达的物质来提供脱毛剂或毛发生长抑制剂，以及 利用这些物质的生理活性。 已经发现FGF18抑制毛发生长。 公开了筛选FGF18样活性物质的方法，促进FGF18活性的物质或促进FGF18表达的物质，从​​而获得毛发生长抑制剂或脱毛剂的候选物。 还公开了一种毛发生长抑制剂或脱毛剂，其包含作为活性成分的FGF18和/或FGF18部分肽或FGF18样活性物质和/或促进FGF18活性或表达的物质（ 例如，Digenea单克隆提取物）。