公开(公告)号：US20100203055A1

公开(公告)日：2010-08-12

申请号：US12527694

申请日：2008-02-19

申请人： Toru Imamura ,  Miho Kimura ,  Mitsuko Kawano ,  Nozomi Tsujino ,  Akiko Kuramochi ,  Yuko Oda ,  Kaori Motomura ,  Masashi Suzuki ,  Masahiro Asada ,  Azusa Kameyama ,  Sumie Togayachi ,  Syuichi Oka

发明人： Toru Imamura ,  Miho Kimura ,  Mitsuko Kawano ,  Nozomi Tsujino ,  Akiko Kuramochi ,  Yuko Oda ,  Kaori Motomura ,  Masashi Suzuki ,  Masahiro Asada ,  Azusa Kameyama ,  Sumie Togayachi ,  Syuichi Oka

IPC分类号： A61K39/395 ,  A61K38/02 ,  A61K36/42 ,  A61K31/7088 ,  A61P17/14 ,  C12Q1/02

CPC分类号： A61K36/42 ,  A01K2227/105 ,  A61K8/64 ,  A61K8/97 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/1825 ,  A61K45/06 ,  A61K2800/70 ,  A61Q7/00

摘要： It is intended to provide a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia by determining an endogenous factor that inhibits hair growth and screening for substances that inhibit the activity or expression of the endogenous factor. It has been found that FGF18 inhibits hair growth. A method of screening for substances that inhibit the activity of FGF18 or substances that inhibit the expression of FGF18 to thereby obtain candidates for the hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia is disclosed. Also disclosed is a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia comprising, as an active ingredient(s), a substance that inhibit the activity of FGF18 and/or a substance that inhibits the expression of FGF18 such as a partial peptide of FGF18 or a Momordica charantia hot water extract.

摘要翻译： 旨在通过测定抑制毛发生长的内源因子和筛选抑制内源性因子的活性或表达的物质来提供毛发生长促进剂，毛发再生促进剂或脱发治疗剂。 已经发现FGF18抑制毛发生长。 公开了筛选抑制FGF18活性的物质或抑制FGF18表达的物质从而获得毛发生长促进剂，毛发再生促进剂或脱发治疗剂的候选物的方法。 还公开了一种毛发生长促进剂，头发再生促进剂或脱发治疗剂，其包含作为活性成分的抑制FGF18活性的物质和/或抑制FGF18表达的物质，例如部分 FGF18肽或苦瓜热水提取物。

公开(公告)号：US20100183733A1

公开(公告)日：2010-07-22

申请号：US12527693

申请日：2008-02-19

申请人： Toru Imamura ,  Miho Kimura ,  Mitsuko Kawano ,  Nazomi Tsujino ,  Akiko Kuramochi ,  Yuko Oda ,  Kaori Motomura ,  Masashi Suzuki ,  Masahiro Asada ,  Azusa Kameyama ,  Sumie Togayachi ,  Syuichi Oka

发明人： Toru Imamura ,  Miho Kimura ,  Mitsuko Kawano ,  Nazomi Tsujino ,  Akiko Kuramochi ,  Yuko Oda ,  Kaori Motomura ,  Masashi Suzuki ,  Masahiro Asada ,  Azusa Kameyama ,  Sumie Togayachi ,  Syuichi Oka

IPC分类号： A61K8/98 ,  C07K14/50 ,  A61K8/64 ,  A61Q9/04 ,  C12N15/63 ,  C12Q1/68

CPC分类号： C07K14/43536 ,  A61K8/64 ,  A61Q7/02 ,  G01N33/566 ,  G01N2333/50 ,  G01N2500/10

摘要： A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).

摘要翻译： 通过测定具有毛发生长抑制活性的内源性因子，筛选具有与内源因子相似的活性的物质或增强内源性因子的活性或表达的物质来提供脱毛剂或毛发生长抑制剂，以及 利用这些物质的生理活性。 已经发现FGF18抑制毛发生长。 公开了筛选FGF18样活性物质的方法，促进FGF18活性的物质或促进FGF18表达的物质，从​​而获得毛发生长抑制剂或脱毛剂的候选物。 还公开了一种毛发生长抑制剂或脱毛剂，其包含作为活性成分的FGF18和/或FGF18部分肽或FGF18样活性物质和/或促进FGF18活性或表达的物质（ 例如，Digenea单克隆提取物）。

公开(公告)号：US08697369B2

公开(公告)日：2014-04-15

申请号：US12594210

申请日：2008-04-07

申请人： Masashi Suzuki ,  Toru Imamura ,  Yuriko Uehara ,  Kaori Motomura ,  Junko Oki ,  Syuichi Oka ,  Masahiro Asada ,  Akiko Kuramochi ,  Miho Kimura

发明人： Masashi Suzuki ,  Toru Imamura ,  Yuriko Uehara ,  Kaori Motomura ,  Junko Oki ,  Syuichi Oka ,  Masahiro Asada ,  Akiko Kuramochi ,  Miho Kimura

IPC分类号： C12Q1/68

CPC分类号： G01N33/6893 ,  A61K31/727 ,  A61K38/1825 ,  A61K38/47 ,  A61K45/06 ,  C12N9/2434 ,  C12N9/2445 ,  C12N2503/02 ,  C12Y302/01021 ,  C12Y302/01031 ,  G01N2333/50 ,  G01N2500/10 ,  G01N2800/044 ,  A61K2300/00

摘要： Using betaKlotho or a substance that increases or inhibits betaKlotho activity as an agent for controlling the activity of FGF21 mediated by an FGF receptor, the present invention provides a pharmaceutical composition comprising such betaKlotho or such substance as an active ingredient, particularly, a pharmaceutical composition for anti-metabolic syndrome, and further particularly, a pharmaceutical composition for therapeutic or preventive use associated with the control of blood glucose level. In addition, the present invention provides a screening system for each of a substance that enhances or suppresses betaKlotho activity, an FGF21-like active substance, and a betaKlotho-like active substance, which uses a cell system that has expressed an FGF receptor and/or betaKlotho on the surface thereof.

摘要翻译： 使用βKlotho或增加或抑制βKlotho活性作为用于控制由FGF受体介导的FGF21的活性的药剂的物质，本发明提供包含这种βKlotho或这种物质作为活性成分的药物组合物，特别是用于 抗代谢综合征，特别是与控制血糖水平相关的治疗或预防用药物组合物。 此外，本发明提供了用于增强或抑制βKlotho活性的物质，FGF21样活性物质和βKlotho样活性物质的筛选系统，其使用已表达FGF受体的细胞系和/ 或其表面上的βKlotho。

公开(公告)号：US20100184665A1

公开(公告)日：2010-07-22

申请号：US12594210

申请日：2008-04-07

申请人： Masashi Suzuki ,  Toru Imamura ,  Yuriko Uehara ,  Kaori Motomura ,  Junko Oki ,  Syuichi Oka ,  Masahiro Asada ,  Akiko Kuramochi ,  Miho Kimura

发明人： Masashi Suzuki ,  Toru Imamura ,  Yuriko Uehara ,  Kaori Motomura ,  Junko Oki ,  Syuichi Oka ,  Masahiro Asada ,  Akiko Kuramochi ,  Miho Kimura

IPC分类号： A61K38/16 ,  C07K14/00 ,  C07H21/04 ,  A61K31/7088 ,  A61P3/10 ,  C12Q1/68

CPC分类号： G01N33/6893 ,  A61K31/727 ,  A61K38/1825 ,  A61K38/47 ,  A61K45/06 ,  C12N9/2434 ,  C12N9/2445 ,  C12N2503/02 ,  C12Y302/01021 ,  C12Y302/01031 ,  G01N2333/50 ,  G01N2500/10 ,  G01N2800/044 ,  A61K2300/00

摘要： Using betaKlotho or a substance that increases or inhibits betaKlotho activity as an agent for controlling the activity of FGF21 mediated by an FGF receptor, the present invention provides a pharmaceutical composition comprising such betaKlotho or such substance as an active ingredient, particularly, a pharmaceutical composition for anti-metabolic syndrome, and further particularly, a pharmaceutical composition for therapeutic or preventive use associated with the control of blood glucose level. In addition, the present invention provides a screening system for each of a substance that enhances or suppresses betaKlotho activity, an FGF21-like active substance, and a betaKlotho-like active substance, which uses a cell system that has expressed an FGF receptor and/or betaKlotho on the surface thereof.

摘要翻译： 使用βKlotho或增加或抑制βKlotho活性作为用于控制由FGF受体介导的FGF21的活性的药剂的物质，本发明提供包含这种βKlotho或这种物质作为活性成分的药物组合物，特别是用于 抗代谢综合征，特别是与控制血糖水平相关的治疗或预防用药物组合物。 此外，本发明提供了用于增强或抑制βKlotho活性的物质，FGF21样活性物质和βKlotho样活性物质的筛选系统，其使用已表达FGF受体的细胞系和/ 或其表面上的βKlotho。

公开(公告)号：US07282481B2

公开(公告)日：2007-10-16

申请号：US11285798

申请日：2005-11-23

申请人： Toru Imamura ,  Masahiro Asada ,  Syuichi Oka ,  Masashi Suzuki ,  Atsuko Yoneda ,  Keiko Ota ,  Yuko Oda ,  Kazuko Miyakawa ,  Noriko Orikasa ,  Chie Asada ,  Tetsuhito Kojima

发明人： Toru Imamura ,  Masahiro Asada ,  Syuichi Oka ,  Masashi Suzuki ,  Atsuko Yoneda ,  Keiko Ota ,  Yuko Oda ,  Kazuko Miyakawa ,  Noriko Orikasa ,  Chie Asada ,  Tetsuhito Kojima

IPC分类号： A61K38/18 ,  C07K14/475

CPC分类号： C07K14/4723 ,  A61K38/1709

摘要： A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method of functionalizing a natural protein having no sugar chain by covalently bonding thereto a sugar chain.

摘要翻译： 通过与糖链共价键合的肝素结合蛋白质，该蛋白质的制造方法和含有该蛋白质作为活性成分的药物组合物，以及通过共价键合而不含糖链的天然蛋白质的功能化方法 糖链。

公开(公告)号：US20060079451A1

公开(公告)日：2006-04-13

申请号：US11285798

申请日：2005-11-23

申请人： Toru Imamura ,  Masahiro Asada ,  Syuichi Oka ,  Masashi Suzuki ,  Atsuko Yoneda ,  Keiko Ota ,  Yuko Oda ,  Kazuko Miyakawa ,  Noriko Orikasa ,  Chie Asada ,  Tetsuhito Kojima

发明人： Toru Imamura ,  Masahiro Asada ,  Syuichi Oka ,  Masashi Suzuki ,  Atsuko Yoneda ,  Keiko Ota ,  Yuko Oda ,  Kazuko Miyakawa ,  Noriko Orikasa ,  Chie Asada ,  Tetsuhito Kojima

IPC分类号： A61K38/16 ,  C07K14/47

CPC分类号： C07K14/4723 ,  A61K38/1709

摘要： A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method of functionalizing a natural protein having no sugar chain by covalently bonding thereto a sugar chain.

摘要翻译： 通过与糖链共价键合的肝素结合蛋白质，该蛋白质的制造方法和含有该蛋白质作为活性成分的药物组合物，以及通过共价键合而不含糖链的天然蛋白质的功能化方法 糖链。

公开(公告)号：US07005415B1

公开(公告)日：2006-02-28

申请号：US09121017

申请日：1998-07-22

申请人： Toru Imamura ,  Masahiro Asada ,  Syuichi Oka ,  Masashi Suzuki ,  Atsuko Yoneda ,  Keiko Ota ,  Yuko Oda ,  Kazuko Miyakawa ,  Noriko Orikasa ,  Chie Asada ,  Tetsuhito Kojima

发明人： Toru Imamura ,  Masahiro Asada ,  Syuichi Oka ,  Masashi Suzuki ,  Atsuko Yoneda ,  Keiko Ota ,  Yuko Oda ,  Kazuko Miyakawa ,  Noriko Orikasa ,  Chie Asada ,  Tetsuhito Kojima

IPC分类号： A61K38/16 ,  A61K38/18 ,  C07K14/435 ,  C07K14/475

CPC分类号： C07K14/4723 ,  A61K38/1709

摘要： A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method for functionalizing a natural protein having no sugar chain by covalently bonding thereto a sugar chain.

摘要翻译： 通过与糖链共价键合的肝素结合蛋白质，该蛋白质的制造方法和含有该蛋白质作为活性成分的药物组合物，以及通过共价键合而使不含糖链的天然蛋白质官能化的方法 糖链。

公开(公告)号：US5874254A

公开(公告)日：1999-02-23

申请号：US822573

申请日：1997-03-19

申请人： Toru Imamura ,  Syuichi Oka ,  Kazuo Ozawa ,  Chieri Sato ,  Seigo Suzuki

发明人： Toru Imamura ,  Syuichi Oka ,  Kazuo Ozawa ,  Chieri Sato ,  Seigo Suzuki

IPC分类号： A61K38/00 ,  C07K14/50 ,  C12N15/16 ,  A61K38/18

CPC分类号： C07K14/50 ,  A61K38/00

摘要： The present invention relates to a novel FGF-5 analogous protein derived from mature mRNA formed by directly binding exon 1 to exon 3 in the splicing of a gene coding for FGF-5 protein as well as to a pharmaceutical composition containing the same as an active ingredient. The pharmaceutical composition containing the novel FGF-5 analogous protein of the present invention as an active ingredient can regulate physiological functions of FGF-5, such as regulation of restoration or development of hairs on the head and body, regulation of trophic and functional regulation in the brain and nervous system, proliferation of fibroblasts, etc.

摘要翻译： 本发明涉及从编码FGF-5蛋白的基因剪接中直接结合外显子1至外显子3而形成的成熟mRNA的新型FGF-5类似蛋白，以及含有该FGF-5蛋白的药物组合物 成分。 含有本发明的新型FGF-5类似蛋白质作为活性成分的药物组合物可以调节FGF-5的生理功能，例如调节头部和身体上毛发的恢复或发育，调节营养和功能调节 脑和神经系统，成纤维细胞的增殖等

公开(公告)号：US07750115B2

公开(公告)日：2010-07-06

申请号：US10594736

申请日：2005-03-28

申请人： Syuichi Oka ,  Akinori Tsuruda ,  Yasuhiro Kawano ,  Mitsuo Suzuki ,  Satoshi Nakazato

发明人： Syuichi Oka ,  Akinori Tsuruda ,  Yasuhiro Kawano ,  Mitsuo Suzuki ,  Satoshi Nakazato

IPC分类号： C07K7/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/08 ,  C07K5/1008 ,  C07K5/1024

摘要： It is intended to provide a novel oligopeptide which can be relatively easily produced, has not only a hair growth-stimulating effect but also an effect of promoting the growth of epithelial cells (for example, skin regeneration) and can easily pass through the horny layer to thereby reach the desired target cells in which its effects are to be exerted. Namely, water-soluble oligopeptides containing a proryl isoleucyl glycyl unit or an isoleucyl glycyl serine unit and having from 3 to 7 amino acids and water-soluble salts thereof.

摘要翻译： 旨在提供可以相对容易地生产的新型寡肽，不仅具有毛发生长刺激作用，而且还具有促进上皮细胞生长（例如皮肤再生）的作用，并且可以容易地通过角质层 从而到达其效果将被施加的期望靶细胞。 即，含有脯氨酰基异亮氨酰甘氨酰单元或异亮氨酰甘氨酰丝氨酸单元并具有3至7个氨基酸及其水溶性盐的水溶性寡肽。

公开(公告)号：US08304393B2

公开(公告)日：2012-11-06

申请号：US12662761

申请日：2010-05-03

申请人： Syuichi Oka ,  Akinori Tsuruda ,  Yasuhiro Kawano ,  Mitsuo Suzuki ,  Satoshi Nakazato

发明人： Syuichi Oka ,  Akinori Tsuruda ,  Yasuhiro Kawano ,  Mitsuo Suzuki ,  Satoshi Nakazato

IPC分类号： A61K38/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/08 ,  C07K5/1008 ,  C07K5/1024

摘要： It is intended to provide a novel oligopeptide which can be relatively easily produced, has not only a hair growth-stimulating effect but also an effect of promoting the growth of epithelial cells (for example, skin regeneration) and can easily pass through the horny layer to thereby reach the desired target cells in which its effects are to be exerted. Namely, water-soluble oligopeptides containing a proryl isoleucyl glycyl unit or an isoleucyl glycyl serine unit and having from 3 to 7 amino acids and water-soluble salts thereof.

摘要翻译： 旨在提供可以相对容易地生产的新型寡肽，不仅具有毛发生长刺激作用，而且还具有促进上皮细胞生长（例如皮肤再生）的作用，并且可以容易地通过角质层 从而到达其效果将被施加的期望靶细胞。 即，含有脯氨酰基异亮氨酰甘氨酰单元或异亮氨酰甘氨酰丝氨酸单元并具有3至7个氨基酸及其水溶性盐的水溶性寡肽。