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公开(公告)号：US07846475B2
公开(公告)日：2010-12-07
申请号：US10481892
申请日：2002-07-03
CPC分类号： A61K9/4825 , A61K31/714
摘要： The present invention provides soft capsules comprising a capsule shell having a water activity lower than that of a capsule filling; and a production process of the soft capsules. The present invention makes it possible to prepare soft capsules without lowering the water activity of an active ingredient of a medicament or the like, which activity varies widely, depending on the active ingredient employed, leading to the provision of the soft capsules having original unimpaired properties or stability, and moreover, palatability and texture.
摘要翻译： 本发明提供了一种软胶囊，其包含水分活度低于胶囊填充物的胶囊壳; 和软胶囊的生产过程。 本发明使得可以制备软胶囊，而不会降低活性成分的药物等的活性成分，这种活性根据所使用的活性成分而变化很大，导致提供具有原始未受损性质的软胶囊 或稳定性，而且适口性和质感。
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公开(公告)号：US20090030091A1
公开(公告)日：2009-01-29
申请号：US11972196
申请日：2008-01-10
申请人： Sumihiro Shiraishi , Yusuke Suzuki
发明人： Sumihiro Shiraishi , Yusuke Suzuki
CPC分类号： A61K9/4883 , A61K9/4816
摘要： The present invention provides a film composition containing caramel (Caramel I, II, III or IV) as a brown colorant, particularly a film composition containing a water-soluble cellulose derivative as a base component and suitably used for a capsule base, the film composition ensuring high degree of transparency because of the suppression of caramel aggregation. The present invention also provides a method for preparing the brown film composition. The present invention is enforced by adjusting pH of an aqueous solution in forming a film composition, which is obtained by solidification of an aqueous solution containing a water-soluble cellulose derivative and caramel, to a predetermined range using a pH adjuster.
摘要翻译： 本发明提供一种含有焦糖（焦糖I，II，III或IV）作为棕色着色剂的薄膜组合物，特别是含有水溶性纤维素衍生物作为基础成分并适合用于胶囊基质的薄膜组合物，该薄膜组合物 由于抑制焦糖聚集，确保高透明度。 本发明还提供一种制备棕色膜组合物的方法。 本发明通过使用pH调节剂将通过使含有水溶性纤维素衍生物和焦糖的水溶液固化至预定范围获得的膜组合物来调节水溶液的pH来实施本发明。
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公开(公告)号：US5077048A
公开(公告)日：1991-12-31
申请号：US464522
申请日：1990-01-12
申请人： Isami Kimura , Akemi Kamiya , Sumihiro Shiraishi , Makoto Sato
发明人： Isami Kimura , Akemi Kamiya , Sumihiro Shiraishi , Makoto Sato
IPC分类号： A61K31/715 , A61K9/08 , A61K31/19 , A61K31/765 , A61K31/77 , A61K33/04 , A61K33/14 , A61P1/10
CPC分类号： A61K33/14 , Y10S514/892
摘要： A bowel lavage composition which comprises one or more of a water-soluble polymer selected from the group consisting of polyethylene glycol, dextran, dextrin, hydroxyethylated starch, polydextrose, arabic gum, pullulan and pectin; a sodium salt of an organic; a potassium salt of an organic acid; sodium chloride; potassium chloride and sodium sulfate, having the following formulation:______________________________________ Water-soluble polymer 10-150 g Sodium salt of an organic acid 5-60 mmol Potassium salt of an organic acid 0-12 mmol Sodium chloride 7-60 mmol Potassium chloride 0-12 mmol Sodium sulfate 0-20 mmol ______________________________________ wherein total potassium ion content in said composition ranges from 2 to 12 mEq. The bowel lavage composition is easily prepared in the form of the lavage solution when used, which is easily taken by patients, has reduced absorption of water, does not exert influence upon the electrolyte balance in living body with an excellent cleansing effect, does not contain hydrogen carbonate ion, and hence, is pharmaceutically stable and can be stored for a long period of time.
摘要翻译： 一种肠灌洗组合物，其包含一种或多种选自聚乙二醇，葡聚糖，糊精，羟乙基化淀粉，聚右旋糖，阿拉伯树胶，支链淀粉和果胶中的水溶性聚合物; 有机钠盐; 有机酸的钾盐; 氯化钠; 氯化钾和硫酸钠，具有以下配方： - 水溶性聚合物10-150克 - 有机酸的钠盐5-60毫摩尔 - 有机酸的钾盐0-12毫摩尔 - 氯化钠7-60毫摩尔 - 氯化钾0-12mmol - 硫酸钠0-20mmol - 其中所述组合物中的总钾离子含量为2至12mEq。 肠灌洗组合物使用时可以以灌洗溶液的形式容易地制备，容易被患者摄取，具有降低的吸收水分，不会对生物体内的电解质平衡产生影响，具有优异的清洁效果，不含 碳酸氢根离子，因此是药学上稳定的并且可以长期储存。
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公开(公告)号：US20090010975A1
公开(公告)日：2009-01-08
申请号：US12213586
申请日：2008-06-20
申请人： Sumihiro Shiraishi
发明人： Sumihiro Shiraishi
CPC分类号： C09D5/024 , A23L29/015 , A23L29/262 , A23P10/30 , A23P20/00 , A23P20/105 , A23V2002/00 , A61K8/19 , A61K8/731 , A61K9/4891 , C08L1/284 , A23V2200/22 , A23V2250/51086 , A23V2250/156
摘要： The present invention provides a non-transparent film composition that has light-shielding properties and can thereby maintain the stability and quality of products, such as formulations, for a long period of time; and formulations using this film composition, and particularly filled capsules. The non-transparent film composition contains a water-soluble metal compound containing at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminium, manganese, iron, cobalt, nickel, copper, strontium, and barium; and a water-soluble cellulose derivative. The non-transparent film composition is preferably prepared by: spreading an aqueous solution containing a water-soluble cellulose derivative and a water-soluble metal compound containing a monovalent, divalent or trivalent metal into a film- or sheet-like form; and heating the solution at a temperature of 60° C. or higher to obtain the film composition by drying and solidification.
摘要翻译： 本发明提供一种具有遮光性的非透明膜组合物，能够长时间保持制剂等制剂的稳定性和质量; 和使用该膜组合物的制剂，特别是填充胶囊。 该非透明膜组合物含有含有选自钠，钾，钙，镁，铝，锰，铁，钴，镍，铜，锶和钡中的至少一种金属的水溶性金属化合物; 和水溶性纤维素衍生物。 非透明膜组合物优选通过以下方式制备：将含有水溶性纤维素衍生物的水溶液和含有一价，二价或三价金属的水溶性金属化合物铺展成薄膜或片状形式; 并在60℃以上的温度下加热溶液，通过干燥固化得到膜组合物。
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公开(公告)号：US20080245289A1
公开(公告)日：2008-10-09
申请号：US11964804
申请日：2007-12-27
申请人： Sumihiro Shiraishi
发明人： Sumihiro Shiraishi
IPC分类号： G01D21/00
摘要： The present invention provides a film or a sheet-like moisture indicator that allows one to visually recognize moisture by changing from a non-transparent color such as white to transparent when it is moistened. The present invention also provides a film or a sheet-like time indicator that allows one to visually recognize the passage of a predetermined length of time by becoming transparent when it is moistened.The indicator of the invention has a water-soluble, non-transparent layer formed of a non-transparent, dry film composition, which comprises a water-soluble cellulose derivative, as well as a water-soluble compound containing at least one metal selected from the group consisting of monovalent, divalent, and trivalent metals. The indicator may further comprise, on the water-soluble, non-transparent layer, a water-soluble transparent layer, a water-insoluble support layer, and/or an attachment layer (an adhesive layer and a release paper therefor) for attaching the indicator to a test target.
摘要翻译： 本发明提供了一种薄膜或片状湿度指示器，其允许通过在被润湿时从诸如白色的不透明颜色变为透明而直观地识别水分。 本发明还提供了一种薄膜或片状时间指示器，其允许人们通过在被润湿时变得透明地目视识别预定时间长度的通过。 本发明的指示剂具有由非透明干膜组合物形成的水溶性不透明层，其包含水溶性纤维素衍生物，以及含有至少一种选自以下的金属的水溶性化合物： 由一价，二价和三价金属组成的组。 指示剂还可以在水溶性非透明层上包含水溶性透明层，水不溶性支撑层和/或附着层（用于粘合剂层及其剥离纸），用于将 指标到测试目标。
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6.发明申请Composition for gelatin coating, gelatin coating, and preparation using the same 审中-公开用于明胶包衣，明胶包衣的组合物及其制备公开(公告)号：US20060182798A1
公开(公告)日：2006-08-17
申请号：US11342324
申请日：2006-01-26
IPC分类号： A61K9/64
CPC分类号： A61K9/4825 , A61K9/2873
摘要： The present invention relates to a composition for gelatin coating and a gelatin coating characterized by containing a gelatin (A) and an inositol phosphate (B) represented by a general formula: C6H12-n.(H2PO4)n (in the formula, n represents an integer from 1 to 6), and a preparation using the same.
摘要翻译： 本发明涉及一种用于明胶包衣的组合物和明胶包衣，其特征在于含有由以下通式表示的明胶（A）和磷酸肌醇（B）：C 6 H 12 - （在式中，n表示1〜6的整数），以及（Ⅳ）表示and and and and and and and and and and and and and and and and and and and and and and and and and and and and and 一个使用它的准备。
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公开(公告)号：US20060118003A1
公开(公告)日：2006-06-08
申请号：US10539021
申请日：2003-12-16
IPC分类号： C09C1/02
CPC分类号： A61K31/4422 , A61K9/2813 , A61K9/282 , A61K9/2866
摘要： A light-shielding agent and a film-forming composition containing it, which prevent separation of formulation surfaces or powder floating phenomenon, which are caused by irradiation by light or ultraviolet light, improve luster of formulation surfaces, maintain external appearance of formulations, and do not impair stability or quality of pharmaceutical preparations, or the like, are provided. The light-shielding agent includes a calcium-containing compound, and the film-forming composition includes the light-shielding agent including the calcium-containing compound and a film-forming base agent. The present invention also provides a formulation and a capsule, which are coated with both or either of the above-mentioned light-shielding agent and/or the above-mentioned film-forming composition.
摘要翻译： 遮光剂和含有它的成膜组合物，其防止由光或紫外线照射引起的配方表面分离或粉末漂浮现象，改善制剂表面的光泽，保持制剂的外观，并做 不损害药物制剂的稳定性或质量等。 遮光剂包括含钙化合物，并且成膜组合物包括包含含钙化合物的遮光剂和成膜基剂。 本发明还提供了用上述遮光剂和/或上述成膜组合物中的任一种涂覆的制剂和胶囊。
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公开(公告)号：US6146638A
公开(公告)日：2000-11-14
申请号：US319690
申请日：1999-06-10
IPC分类号： A23L1/212 , A23L1/221 , A23L1/23 , A23L1/30 , A61K36/062 , A61K36/8962 , A61K36/899 , A01N65/00 , A61K9/14 , A61K47/00
CPC分类号： A61K36/062 , A23L19/01 , A23L19/09 , A23L27/105 , A23L27/24 , A23L33/105 , A61K36/8962 , A61K36/899
摘要： The present invention relates to a composition prepared by fermenting enzymatically-deactivated garlic with Aspergillus and/or Monascus, to a process for preparing the same, and also to foods and drugs containing the same. The composition is free from any unpleasant odor and is useful as a prophylactic or therapeutic agent for diabetes, hepatic diseases, cancer, immunopathy, hyperlipemia, and the like.
摘要翻译： PCT No.PCT / JP97 / 04327 Sec。 371日期1999年6月10日第 102（e）1999年6月10日PCT 1997年11月27日PCT公布。 WO98 / 25481 PCT出版物 日本1998年6月18日本发明涉及通过用曲霉属和/或红曲霉发酵酶促失活的大蒜制备的组合物，其制备方法，以及含有该组合物的食品和药物。 该组合物没有任何不愉快的气味，并且可用作糖尿病，肝脏疾病，癌症，免疫病，高脂血症等的预防或治疗剂。
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