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1.发明申请METHODS FOR DETERMINING CORRELATED RESIDUES IN A PROTEIN OR OTHER BIOPOLYMER USING MOLECULAR DYNAMICS 有权使用分子动力学测定蛋白质或其他生物聚合物中相关残基的方法公开(公告)号：US20110053261A1
公开(公告)日：2011-03-03
申请号：US12866437
申请日：2009-02-05
申请人： Paula I. Lario , Johannes Mullegger , Anne-Marie Baribeau , Surjit B. Dixit , Tomas Rodinger , Powell Patrick Cheng Tan
发明人： Paula I. Lario , Johannes Mullegger , Anne-Marie Baribeau , Surjit B. Dixit , Tomas Rodinger , Powell Patrick Cheng Tan
摘要： The invention provides methods and systems of determining biopolymer profiles and correlations between structural units (residues) of a biopolymer based on sampling of the conformational space available to the molecule. The correlations between these structural units can further be used to find networks within a biopolymer such as the coupled residue networks in a protein. The invention also provides for designing and engineering biopolymers including polypeptides, nucleic acids and carbohydrates using the information derived from the conformation clustering and subsequent methods described herein.
摘要翻译： 本发明提供了基于对分子可用的构象空间的取样来确定生物聚合物的生物聚合物分布和生物聚合物的结构单元（残基）之间的相关性的方法和系统。 这些结构单元之间的相关性可进一步用于在生物聚合物内发现网络，例如蛋白质中的偶联残基网络。 本发明还提供使用本文所述的构象聚类和随后方法得到的信息来设计和工程生物聚合物，包括多肽，核酸和碳水化合物。
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公开(公告)号：US20130108623A1
公开(公告)日：2013-05-02
申请号：US13638558
申请日：2011-03-28
申请人： Igor D'Angelo , Dustin Bleile , Stacey A.L. Tom-Yew , Eric Escobar-Cabrera , Paula I. Lario , Anders Ohrn , David K.Y. Poon , Surjit B. Dixit
发明人： Igor D'Angelo , Dustin Bleile , Stacey A.L. Tom-Yew , Eric Escobar-Cabrera , Paula I. Lario , Anders Ohrn , David K.Y. Poon , Surjit B. Dixit
IPC分类号： C07K16/28
CPC分类号： C07K16/32 , C07K14/70535 , C07K16/00 , C07K16/082 , C07K16/28 , C07K16/2803 , C07K16/283 , C07K16/2851 , C07K16/2887 , C07K16/464 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G16B15/00
摘要： Rationally designed antibodies and polypeptides that comprise two Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides comprise Fc region mutations at two positions that synergistically make the polypeptides more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
摘要翻译： 提供了合成设计的抗体和多肽，其包含两个Fc区氨基酸取代，其协同地提供对靶Fc受体的增强的选择性和结合亲和力。 多肽在两个位置上包含Fc区突变，当掺入抗体治疗剂中时，与具有野生型Fc成分的多肽相比，协同使多肽更有效。
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公开(公告)号：US20130089541A1
公开(公告)日：2013-04-11
申请号：US13638362
申请日：2011-03-28
申请人： Igor D'Angelo , Dustin Bleile , Stacey A.L. Tom-Yew , Eric Escobar-Cabrera , Paula I. Lario , Anders Ohrn , David K.Y Poon , Surjit B. Dixit
发明人： Igor D'Angelo , Dustin Bleile , Stacey A.L. Tom-Yew , Eric Escobar-Cabrera , Paula I. Lario , Anders Ohrn , David K.Y Poon , Surjit B. Dixit
CPC分类号： C07K16/32 , C07K14/70535 , C07K16/00 , C07K16/082 , C07K16/28 , C07K16/2803 , C07K16/283 , C07K16/2851 , C07K16/2887 , C07K16/464 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06F19/16
摘要： Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
摘要翻译： 提供合理设计的抗体和多肽，其包含多个Fc区氨基酸取代，其协同地提供对靶Fc受体的增强的选择性和结合亲和力。 多肽在多个位置突变以使其在掺入抗体治疗剂中比具有野生型Fc成分的那些更有效。
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4.发明授权Methods for determining correlated residues in a protein or other biopolymer using molecular dynamics 有权使用分子动力学测定蛋白质或其他生物聚合物中的相关残基的方法公开(公告)号：US09404928B2
公开(公告)日：2016-08-02
申请号：US12866437
申请日：2009-02-05
申请人： Paula I. Lario , Johannes Mullegger , Anne-Marie Baribeau , Surjit B. Dixit , Tomas Rodinger , Powell Patrick Cheng Tan
发明人： Paula I. Lario , Johannes Mullegger , Surjit B. Dixit , Tomas Rodinger , Powell Patrick Cheng Tan
摘要： The invention provides methods and systems of determining biopolymer profiles and correlations between structural units (residues) of a biopolymer based on sampling of the conformational space available to the molecule. The correlations between these structural units can further be used to find networks within a biopolymer such as the coupled residue networks in a protein. The invention also provides for designing and engineering biopolymers including polypeptides, nucleic acids and carbohydrates using the information derived from the conformation clustering and subsequent methods described herein.
摘要翻译： 本发明提供了基于对分子可用的构象空间的取样来确定生物聚合物的生物聚合物分布和生物聚合物的结构单元（残基）之间的相关性的方法和系统。 这些结构单元之间的相关性可进一步用于在生物聚合物内发现网络，例如蛋白质中的偶联残基网络。 本发明还提供使用本文所述的构象聚类和随后方法得到的信息来设计和工程生物聚合物，包括多肽，核酸和碳水化合物。
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公开(公告)号：US09296815B2
公开(公告)日：2016-03-29
申请号：US13638362
申请日：2011-03-28
申请人： Igor D'Angelo , Dustin Bleile , Stacey A. L. Tom-Yew , Eric Escobar-Cabrera , Paula I. Lario , Anders Ohrn , David K. Y. Poon , Surjit B. Dixit
发明人： Igor D'Angelo , Dustin Bleile , Stacey A. L. Tom-Yew , Eric Escobar-Cabrera , Paula I. Lario , Anders Ohrn , David K. Y. Poon , Surjit B. Dixit
CPC分类号： C07K16/32 , C07K14/70535 , C07K16/00 , C07K16/082 , C07K16/28 , C07K16/2803 , C07K16/283 , C07K16/2851 , C07K16/2887 , C07K16/464 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06F19/16
摘要： Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
摘要翻译： 提供合理设计的抗体和多肽，其包含多个Fc区氨基酸取代，其协同地提供对靶Fc受体的增强的选择性和结合亲和力。 多肽在多个位置突变以使其在掺入抗体治疗剂中比具有野生型Fc成分的那些更有效。
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