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公开(公告)号：US20110118218A1
公开(公告)日：2011-05-19
申请号：US12867309
申请日：2009-02-12
申请人： Neil Robert Buck , Wouter Claerhout , Bruno H. Leuenberger , Elisabeth Stoecklin , Kai Urban , Swen Wolfram
发明人： Neil Robert Buck , Wouter Claerhout , Bruno H. Leuenberger , Elisabeth Stoecklin , Kai Urban , Swen Wolfram
IPC分类号： A61K31/593 , C07C401/00 , A61P9/12
CPC分类号： A61K31/593 , A23L33/155 , A23V2002/00 , A23V2200/326 , A23V2250/71
摘要： We disclose the use of optionally in combination with vitamin D3 (cholecalciferol), 25-hydroxyvitamin D3 (cal-cifediol), to treat hypertension. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.
摘要翻译： 我们公开了可选地与维生素D3（胆钙化醇），25-羟基维生素D3（cal-cifediol）组合的治疗高血压的用途。 还公开了药物组合物的形式和剂量，以及制备药物的方法。
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2.发明申请COMBINED USE OF 25-HYDROXY-VITAMIN D3 AND VITAMIN D3 FOR IMPROVING BONE MINERAL DENSITY AND FOR TREATING OSTEOPORISIS 审中-公开组合使用25-羟基维生素D3和维生素D3用于改善骨密度和治疗骨质疏松症公开(公告)号：US20110039809A1
公开(公告)日：2011-02-17
申请号：US12867316
申请日：2009-02-12
申请人： Neil Robert Buck , Wouter Claerhout , Bruno H. Leuenberger , Elisabeth Stoecklin , Kai Urban , Swen Wolfram
发明人： Neil Robert Buck , Wouter Claerhout , Bruno H. Leuenberger , Elisabeth Stoecklin , Kai Urban , Swen Wolfram
IPC分类号： A61K31/593 , A61P19/08 , A61P19/10
CPC分类号： A61K31/593 , A23L33/155
摘要： We disclose the combined use of vitamin D (cholecalciferol) and 25-OH D3 (calcifediol) to treat and/or prevent osteoporosis. One or more bisphosphonate compounds to inhibit bone resorption may also be used. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.
摘要翻译： 我们公开了维生素D（胆钙化醇）和25-OH D3（calcifediol）联合使用以治疗和/或预防骨质疏松症。 还可以使用一种或多种抑制骨吸收的二膦酸化合物。 还公开了药物组合物的形式和剂量，以及制备药物的方法。
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公开(公告)号：US07691420B2
公开(公告)日：2010-04-06
申请号：US10573222
申请日：2004-09-15
CPC分类号： A61K36/82 , A23L33/105 , A23L33/12 , A23V2002/00 , A61K31/353 , A61K45/06 , A61K2300/00 , A23V2250/1882 , A23V2250/214
摘要： Compositions comprising a catechin as found in green tea, e.g., epigallocatechin gallate, and ligand which activates the peroxisome proliferatoractivated receptor gamma (PPAR-gamma are useful for the treatment and prevention of diabetes mellitus).
摘要翻译： 包含绿茶中发现的儿茶素的组合物，例如表没食子儿茶素没食子酸酯，以及激活过氧化物酶体增殖激活受体γ（PPAR-γ）的配体可用于治疗和预防糖尿病。
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4.发明申请Compounds for the Treatment of Non-Autoimmune Type 2 Diabetes Mellitus and/or Syndrome X 审中-公开用于治疗非自身免疫性2型糖尿病和/或综合征X的化合物公开(公告)号：US20090203773A1
公开(公告)日：2009-08-13
申请号：US11922604
申请日：2006-06-23
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schuler , Ying Wang-Schmidt , Christof Wehrli , Swen Wolfram , Karin Wertz , Daniel Raederstorff
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schuler , Ying Wang-Schmidt , Christof Wehrli , Swen Wolfram , Karin Wertz , Daniel Raederstorff
IPC分类号： A61K31/357 , C07D317/44 , C07C69/76 , A61K31/235 , A61P3/10
CPC分类号： C07H15/04 , C07C49/796 , C07C49/835 , C07C49/84 , C07C69/618 , C07C69/78 , C07C233/33 , C07D317/64
摘要： The present invention relates to compounds of the formula (I); wherein R1 is H, CH3 or OCH3; R3=H, OH, CH3, OCH3, O-glucose or benzoyloxy; R4=H; R5=H or OH; R6=H or OCH3; R7=H, CH3, OCH3, cinnamoyloxy or (3,4,5-trimethoxy)-benzoyloxy; R8=H, OH, CH3 or OCH3; or R7 and R8 form together a group 0-CH2—O; R9=H or OCH3; R10=H or N-acetyl, N-methyl-2-aminoethyl; to their use as medicament for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X, to dietary and pharmaceutical compositions containing them and to a method for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X in animals including humans, said method comprising the step of administering an effective dose of a compound of the formula (I) to animals including humans which are in need thereof.
摘要翻译： 本发明涉及式（I）的化合物; 其中R1是H，CH3或OCH3; R3 = H，OH，CH3，OCH3，O-葡萄糖或苯甲酰氧基; R4 = H; R5 = H或OH; R6 = H或OCH3; R7 = H，CH3，OCH3，肉桂酰氧基或（3,4,5-三甲氧基） - 苯甲酰氧基; R8 = H，OH，CH3或OCH3; 或者R 7和R 8一起形成O-CH 2 -O基团; R9 = H或OCH3; R 10 = H或N-乙酰基，N-甲基-2-氨基乙基; 用于治疗非自身免疫性2型糖尿病和/或综合征X的药物用于含有它们的膳食和药物组合物以及用于治疗非自身免疫性2型糖尿病和/或症状X的综合征的方法 包括人的动物，所述方法包括向有需要的动物（包括人）施用有效剂量的式（I）化合物的步骤。
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5.发明申请Use of phthalide derivatives for the treatment and prevention of diabetes mellitus 审中-公开使用苯酞衍生物治疗和预防糖尿病公开(公告)号：US20070082947A1
公开(公告)日：2007-04-12
申请号：US10556199
申请日：2004-05-05
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
IPC分类号： A61K31/365
CPC分类号： A61K31/343
摘要： The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
摘要翻译： 本发明涉及化合物作为哺乳动物预防或治疗糖尿病的有效药物的用途。 所述化合物选自苯酞衍生物，表现出优异的降血糖作用，因此是预防或治疗哺乳动物糖尿病的有效药剂。
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公开(公告)号：US20070042057A1
公开(公告)日：2007-02-22
申请号：US10573222
申请日：2004-09-15
IPC分类号： A61K36/82 , A61K31/7048 , A61K31/426 , A61K31/353 , A61K31/202
CPC分类号： A61K36/82 , A23L33/105 , A23L33/12 , A23V2002/00 , A61K31/353 , A61K45/06 , A61K2300/00 , A23V2250/1882 , A23V2250/214
摘要： Compositions comprising a catechin as found in green tea, e.g., epigallocatechin gallate, and ligand which activates the peroxisome proliferatoractivated receptor gamma (PPAR-gamma are useful for the treatment and prevention of diabetes mellitus).
摘要翻译： 包含绿茶中发现的儿茶素的组合物，例如表没食子儿茶素没食子酸酯，以及激活过氧化物酶体增殖激活受体γ（PPAR-γ）的配体可用于治疗和预防糖尿病。
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7.发明申请Nutraceutical compositions comprising epigallocatechin gallate and raspberry ketone 审中-公开包含表儿儿茶素没食子酸酯和覆盆子酮的营养组合物公开(公告)号：US20050288360A1
公开(公告)日：2005-12-29
申请号：US10536374
申请日：2003-11-20
申请人： Daniel Raederstorff , Peter Weber , Swen Wolfram
发明人： Daniel Raederstorff , Peter Weber , Swen Wolfram
IPC分类号： A21D2/00 , A23C9/13 , A23G9/32 , A23G9/36 , A23G9/42 , A23L1/222 , A23L1/30 , A23L2/02 , A23L2/52 , A23L2/56 , A61K31/12 , A61K31/353 , A61P3/04
CPC分类号： A23G9/42 , A21D2/00 , A23C9/1307 , A23G9/366 , A23L2/02 , A23L2/52 , A23L2/56 , A23L27/12 , A23L33/105 , A23V2002/00 , A61K31/12 , A61K31/353 , A61K2300/00 , A23V2250/211 , A23V2250/032 , A23V2250/5072 , A23V2250/708
摘要： Compositions comprising epigallocatechin gallate and 4-(4-hydroxyphenyl)-2-butanone may be used for the treatment or prevention of obesity or conditions associated with obesity such as non-insulin-dependent diabetes mellitus (NIDDM, type II) and syndrome X. The compositions may find use in the nutritional field as a supplement to food and beverages, as well as as a pharmaceutical formulation.
摘要翻译： 包括表没食子儿茶素没食子酸酯和4-（4-羟基苯基）-2-丁酮的组合物可用于治疗或预防肥胖症或与肥胖相关的病症，例如非胰岛素依赖性糖尿病（NIDDM，II型）和综合征X。 组合物可以在营养领域中用作食品和饮料的补充剂，以及作为药物制剂。
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公开(公告)号：US20130018076A1
公开(公告)日：2013-01-17
申请号：US13606369
申请日：2012-09-07
申请人： Angelika FRIEDEL , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika FRIEDEL , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A61K31/455 , A61P21/00
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
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公开(公告)号：US20120190617A1
公开(公告)日：2012-07-26
申请号：US13321971
申请日：2010-06-10
申请人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A61K31/455 , A61K38/02 , A61P21/00 , C07D213/80
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of niacin and/or trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
摘要翻译： 本发明涉及烟酸和/或葫芦宁化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。
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10.发明授权Compositions comprising epigallocatechin gallate and protein hydrolysate 失效包含表没食子儿茶素没食子酸酯和蛋白质水解产物的组合物公开(公告)号：US08129337B2
公开(公告)日：2012-03-06
申请号：US11883051
申请日：2006-02-02
申请人： Swen Wolfram
发明人： Swen Wolfram
IPC分类号： A61K38/16
CPC分类号： A61K38/018 , A61K31/353
摘要： The present invention describes a composition comprising EGCG and a protein hydrolysate.
摘要翻译： 本发明描述了包含EGCG和蛋白质水解产物的组合物。
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