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公开(公告)号：US20250154594A1
公开(公告)日：2025-05-15
申请号：US18941550
申请日：2024-11-08
Inventor： Ko Eun CHOI , Joong-Seok KIM
IPC: C12Q1/6883 , C12Q1/6874
Abstract: Provided are a blood biomarker for diagnosis, prognosis prediction, or treatment of Parkinson's disease (PD), a method for diagnosing or predicting the prognosis of PD using the same, and a method for screening substances for treating PD, where it is confirmed that the levels of 14 types of miRNA are significantly increased or decreased in the blood of PD patients, and the 14 types of miRNA reflect the correlation between genes and environmental factors identified in subjects with PD, thus the 14 types of miRNA are expected to be used as a diagnostic and prognostic biomarker as well as a new therapeutic target related to the pathological mechanism of PD.
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公开(公告)号：US12288479B2
公开(公告)日：2025-04-29
申请号：US18251840
申请日：2021-10-22
Inventor： Sun Im , Cheol Ki Kim
Abstract: Provided are a self voice training method for a patient with a voice disorder and a user terminal for self voice training. The user terminal for self voice training includes an input device configured to receive a training program selection command of a user, a storage configured to store voice training candidate programs for the user's voice training, a calculator configured to generate first guide content according to a first voice training program selected from among the voice training candidate programs by the user, an output device configured to output the first guide content, and a microphone configured to receive voice output by the user according to the first guide content output through the output device.
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公开(公告)号：US20250113808A1
公开(公告)日：2025-04-10
申请号：US18906789
申请日：2024-10-04
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION
Inventor： Seung Ho YANG , Young-Ho AHN , Jung Eun LEE
IPC: A01K67/0271 , A61K38/17 , A61K48/00 , C12Q1/6886 , G01N33/574
Abstract: The present invention relates to a brain-metastatic lung cancer cell line and a use of Noggin as a marker for brain metastasis of lung cancer. In the present invention, a brain metastatic lung cancer cell line with optimized characteristics for brain metastasis was established by repeatedly transplanting the lung cancer cell line through the carotid artery. In addition, in the brain metastatic lung cancer cell line, the expressions of Noggin protein and its mRNA are reduced, confirming that the motility and invasiveness of cells are reduced and adhesion increased. Therefore, the Noggin protein or its gene is expected to be useful as a biomarker for diagnosis of brain metastasis of lung cancer and its target therapy.
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4.发明申请公开(公告)号：US20250092368A1
公开(公告)日：2025-03-20
申请号：US18559577
申请日：2023-07-11
Inventor： Sung Won KIM , Ayoung JO , Min Jae LIM
IPC: C12N5/071
Abstract: The present invention relates to a method of manufacturing an alveolar organoid using alveolar cell-derived induced pluripotent stem cells. The alveolar organoid manufactured according to the present invention is differentiated from the human alveolar cell-derived induced pluripotent stem cells, and thus induced pluripotent stem cells may efficiently differentiate into alveolar organoids due to the epigenetic memory of alveolar cells. Therefore, the alveolar organoids are expected to be effectively used for research on the pathological process of respiratory diseases, screening for finding therapeutic drugs, and the like.
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公开(公告)号：US20240418726A1
公开(公告)日：2024-12-19
申请号：US18535296
申请日：2023-12-11
Inventor： Yosep CHONG , Kwangil Yim
Abstract: A device and method for extracting a plurality of tile images from specimen cytology slide images divided according to a cell staining method, and classifying a class of at least one of a type of cancer and whether there is cancer according to a cell staining method in any specimen cytology slide image using a prediction model that has undergone annotation-based learning on the specimen cytology slide images or the tile images.
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Patent Agency Ranking
公开(公告)号：US20240374545A1
公开(公告)日：2024-11-14
申请号：US18778440
申请日：2024-07-19
Inventor： Kyo Young SONG , Mi La CHO , Joo Yeon JHUN , Yoon Ju JUNG , Sojung KIM , Seung Yoon LEE , Jin Seok WOO , Kun Hee LEE
IPC: A61K31/155 , A61K35/74 , A61P35/00 , A61P37/04
Abstract: The method for preventing or treating of cancer includes administering a pharmaceutical composition to a subject in need thereof comprising a compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof as an active ingredient. wherein the composition inhibits the growth of cancer cells.
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7.发明公开公开(公告)号：US20240360419A1
公开(公告)日：2024-10-31
申请号：US18647191
申请日：2024-04-26
Inventor： Sung Won KIM , Ayoung JO , Min Jae LIM , Mi Hyun LIM
CPC classification number: C12N5/0691 , C12N5/0062 , C12N5/0688 , C12N5/0697 , C12N2502/27 , C12N2502/28 , C12N2506/45 , C12N2513/00
Abstract: Disclosed is a method of producing vascularized respiratory (airway and alveolar) organoids using blood vessel organoids. More particularly, vascularized respiratory (airway and alveolar) organoids with a vascular network are produced by fusing respiratory (airway and alveolar) organoids with blood vessel organoids to induce vascularization. The vascularized respiratory (airway and alveolar) organoids can have functions very similar to the human respiratory whole region, so they are expected to be transplanted into humans to treat respiratory related diseases or be used as an in vitro respiratory whole region model.
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公开(公告)号：US20240293541A1
公开(公告)日：2024-09-05
申请号：US18564370
申请日：2021-05-26
Inventor： Wan-Uk KIM , Riri KWON , Naeun LEE
IPC: A61K39/00 , A61K39/395 , A61P35/00
CPC classification number: A61K39/4611 , A61K39/3955 , A61K39/4637 , A61P35/00 , A61K2039/505 , A61K2039/585 , A61K2239/39 , A61K2239/57
Abstract: The present invention relates to a Leukocyte-specific protein 1 (LSP1)-deficient T cell-based anticancer immunotherapy. According to the present invention, tumor growth, tumor volume and size were reduced by means of LSP1 knockout, and LSP1 deficiency in T cells increases the number, distribution frequency, migration, and invasion of T cells, and increases the production of an anti-tumor cytokine to inhibit tumor growth and enhance tumor-killing ability. Thus, the present invention can be used for T cell-based immunotherapy.
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9.发明公开公开(公告)号：US20240252106A1
公开(公告)日：2024-08-01
申请号：US18406418
申请日：2024-01-08
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , UNIVERSITY OF SEOUL INDUSTRY COOPERATION FOUNDATION
Inventor： Seung Ho YANG , Young Il KIM , Ha Jin YU
CPC classification number: A61B5/4803 , A61B5/0042 , A61B5/055 , A61B5/4064 , A61B5/7267 , G10L15/063 , G10L15/18 , G10L25/66 , A61B2576/026 , G10L13/02
Abstract: Disclosed is a language area invasion determination apparatus including a memory unit including a language area invasion determination model, and a processor that controls an operation of the language area invasion determination model included in the memory unit. The processor trains the language area invasion determination model by using one or more training utterance data and outputs language area invasion determination data of an examiner by using test utterance data and the trained language area invasion determination model. The training utterance data and the test utterance data include utterance speech data of a speaker.
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10.发明公开公开(公告)号：US20240238343A1
公开(公告)日：2024-07-18
申请号：US18004562
申请日：2021-07-01
Inventor： Sung Won KIM , Do Hyun KIM , Jung Yeon LIM , Sun Hwa PARK , Jung Ho CHUN , Sin-Soo JEUN , Soon A PARK
CPC classification number: A61K35/28 , A61K9/0019 , A61K9/0043 , A61K9/0085 , A61K9/12 , A61P25/28
Abstract: The present invention relates to a pharmaceutical composition comprising nasal inferior turbinate-derived mesenchymal stem cells as an active ingredient, the composition being administered by intranasal or intramaxillary administration by means of olfactory mucosa subepithelial injection, and the like, in order to bypass the blood-brain barrier through a peri-olfactory pathway. The present invention relates to a method in which stem cells, and the like are injected intranasally, thereby enabling various therapeutic materials including the stem cells to be efficiently delivered to the brain and nervous system through the olfactory organ and a trigeminal nervous system pathway, and thus, through the method, it was confirmed that side effects occurring as a result of an entire body being exposed to a drug may be reduced, and further, a sufficient amount of inferior turbinate-derived mesenchymal stem cells may be obtained safely at a desired time at low cost with high efficiency, and it was confirmed that since the composition shares the same genetic origin with the composition-administered subject, the composition exhibits an excellent effect which is the same as or greater than the effects of bone marrow-derived mesenchymal stem cells or adipose-derived mesenchymal stem cells with fewer side effects, and thus, by intranasally administering various therapeutic materials including the nasal inferior turbinate-derived mesenchymal stem cells, the composition is expected to be capable of minimizing side effects and utilized for preventing or developing a treatment for brain and nervous system diseases.
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