METHOD AND SYSTEM FOR NUCLEATION CONTROL IN A CONTROLLED RATE FREEZER (CRF)
    9.
    发明申请
    METHOD AND SYSTEM FOR NUCLEATION CONTROL IN A CONTROLLED RATE FREEZER (CRF) 有权
    控制速度冻结机(CRF)中核心控制的方法与系统

    公开(公告)号:US20120102982A1

    公开(公告)日:2012-05-03

    申请号:US13097724

    申请日:2011-04-29

    IPC分类号: F25D17/04 F25D31/00

    摘要: A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.

    摘要翻译: 提供了控制速率冷冻和成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力,其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。 生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。 目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。