公开(公告)号：US20090099101A1

公开(公告)日：2009-04-16

申请号：US12222492

申请日：2008-08-11

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31/70 ,  A61K31/335

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US06518302B1

公开(公告)日：2003-02-11

申请号：US09889728

申请日：2001-07-20

申请人： Eiji Kobayashi ,  Tuo-Ping Li ,  Tatsuji Enoki ,  Takanari Tominaga ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Eiji Kobayashi ,  Tuo-Ping Li ,  Tatsuji Enoki ,  Takanari Tominaga ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A01N4302

CPC分类号： C07H3/10 ,  C07H11/00 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/903

摘要： Compounds represented by general formula (I) wherein X represents OH or OSO3H; and R represents a substituent other than OH which allows, after leaving, the induction of unsaturated bonds into the 3- and 4-positions of 3,6-anhydrogalactose or its sulfated derivative, and/or a substituent showing a tissue-specific affinity.

摘要翻译： 由通式（I）表示的化合物，其中X表示OH或OSO 3 H; R表示除羟基以外的取代基，其在离去后允许不饱和键诱导3,6-脱水半乳糖或其硫酸化衍生物的3-和4-位，和/或显示组织特异性亲和力的取代基。

公开(公告)号：US06284801B1

公开(公告)日：2001-09-04

申请号：US09380239

申请日：1999-08-27

申请人： Nobuto Koyama ,  Hua-Kang Wu ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Tatsuji Enoki ,  Hiromu Ohnogi ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hua-Kang Wu ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Tatsuji Enoki ,  Hiromu Ohnogi ,  Ikunoshin Kato

IPC分类号： A61K3112

CPC分类号： C07C323/59 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/122 ,  C07C45/60 ,  C07C45/78 ,  C07C49/707 ,  C07C323/58 ,  A23V2200/224 ,  A23V2250/5026 ,  A23V2250/5024 ,  A23V2250/21 ,  A23V2250/70 ,  A23V2250/06 ,  A23V2250/204

摘要： An antirheumatic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-l-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.

摘要翻译： 一种抗风湿剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为 有效成分。

公开(公告)号：US06207652B1

公开(公告)日：2001-03-27

申请号：US09051284

申请日：1998-04-09

申请人： Takeshi Sakai ,  Hideo Kitano ,  Fu-Gong Yu ,  Shinji Nakayama ,  Kaoru Kojima ,  Hitomi Kimura ,  Yoshikuni Nakanishi ,  Kaoru Katayama ,  Takanari Tominaga ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Hideo Kitano ,  Fu-Gong Yu ,  Shinji Nakayama ,  Kaoru Kojima ,  Hitomi Kimura ,  Yoshikuni Nakanishi ,  Kaoru Katayama ,  Takanari Tominaga ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31715

CPC分类号： C12Y302/01078 ,  A61K31/737 ,  C12N9/2494 ,  C12P19/14 ,  C12Y302/01044

摘要： Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

公开(公告)号：US07417031B2

公开(公告)日：2008-08-26

申请号：US11034243

申请日：2005-01-13

申请人： Tatsui Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsui Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A01N43/04 ,  A61K31/715 ,  C07G3/00 ,  C07G11/00 ,  C07G17/00 ,  C07H15/00 ,  C07H17/00 ,  C08B37/00

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US06608032B1

公开(公告)日：2003-08-19

申请号：US09889732

申请日：2001-07-20

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Jun Tomono ,  Takanari Tominaga ,  Eiji Nishiyama ,  Hua-Kang Wu ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Jun Tomono ,  Takanari Tominaga ,  Eiji Nishiyama ,  Hua-Kang Wu ,  Ikunoshin Kato

IPC分类号： A01N4304

CPC分类号： A61K31/7048 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7024 ,  A61K31/7028 ,  C07H3/10 ,  C07H11/00 ,  C07H15/04 ,  Y02A50/411 ,  Y10S977/915

摘要： Medicinal compositions for treating or preventing diabetes, rheumatoid, diseases wherein inflammation should be inhibited, diseases wherein &agr;-glycosidase should be inhibited, diseases wherein the synthesis of prostaglandin should be inhibited, diseases wherein endotoxin shock should be inhibited, diseases wherein the production of interleukin should be inhibited, diseases wherein the production of heme oxygenase should be induced, and diseases wherein the production of tumor necrosis factor or carcinogenesis should be inhibited, which contain as the active ingredient at least one compound selected from the group consisting of 3,6-anhydrogalactopyranose represented by formula (I), its aldehyde, its hydrate and 2-O-methylated derivatives and 2-O-sulfated derivatives thereof.

摘要翻译： 用于治疗或预防糖尿病，类风湿病，其中应该抑制炎症的疾病的药物组合物，应该抑制α-糖苷酶的疾病，应该抑制前列腺素合成的疾病，应该抑制内毒素休克的疾病，其中产生白细胞介素 应该被抑制，其中应该诱导血红素加氧酶的产生的疾病，以及应该抑制肿瘤坏死因子或致癌作用的产生的疾病，其中含有选自下组的至少一种化合物作为活性成分： 由式（I）表示的脱水吡喃半乳糖，其醛，其水合物和2-O-甲基化衍生物及其2-O-硫酸化衍生物。

公开(公告)号：US06593311B2

公开(公告)日：2003-07-15

申请号：US09770504

申请日：2001-01-29

申请人： Takeshi Sakai ,  Hideo Kitano ,  Fu-Gong Yu ,  Shinji Nakayama ,  Kaoru Kojima ,  Hitomi Kimura ,  Yoshikuni Nakanishi ,  Kaoru Katayama ,  Takanari Tominaga ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Hideo Kitano ,  Fu-Gong Yu ,  Shinji Nakayama ,  Kaoru Kojima ,  Hitomi Kimura ,  Yoshikuni Nakanishi ,  Kaoru Katayama ,  Takanari Tominaga ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31715

CPC分类号： C12Y302/01078 ,  A61K31/737 ,  C12N9/2494 ,  C12P19/14 ,  C12Y302/01044

摘要： Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

摘要翻译： 含有硫酸化岩藻糖的多糖和/或其降解产物的细胞凋亡诱导剂，抗癌药和抗癌药以及使用含有硫酸化岩藻糖的多糖和/或降解产物诱导细胞凋亡的方法 作为活性成分。 一种可用于生产含硫酸化岩藻糖多糖的降解产物的降解酶。

公开(公告)号：US06228892B1

公开(公告)日：2001-05-08

申请号：US09423883

申请日：1999-11-15

申请人： Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Nobuto Koyama ,  Ikunoshin Kato

发明人： Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Nobuto Koyama ,  Ikunoshin Kato

IPC分类号： A61K3112

CPC分类号： A61K31/122 ,  A23L33/10 ,  A23V2002/00 ,  Y10S514/826 ,  Y10S514/862 ,  Y10S514/885 ,  Y10S514/886 ,  A23V2250/156

摘要： An antiallergic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.

摘要翻译： 一种抗过敏剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为 有效成分。

公开(公告)号：US20100137228A2

公开(公告)日：2010-06-03

申请号：US12222492

申请日：2008-08-11

申请人： Tatsuji ENOKI ,  Hiroaki SAGAWA ,  Takanari TOMINAGA ,  Eiji NISHIYAMA ,  Nobuto KOYAMA ,  Takeshi SAKAI ,  Fu-Gong YU ,  Katsushige IKAI ,  Ikunoshin KATO

发明人： Tatsuji ENOKI ,  Hiroaki SAGAWA ,  Takanari TOMINAGA ,  Eiji NISHIYAMA ,  Nobuto KOYAMA ,  Takeshi SAKAI ,  Fu-Gong YU ,  Katsushige IKAI ,  Ikunoshin KATO

IPC分类号： A61K31/70 ,  A61K31/335

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US20100048491A2

公开(公告)日：2010-02-25

申请号：US12222492

申请日：2008-08-11

申请人： Tatsuji ENOKI ,  Hiroaki SAGAWA ,  Takanari TOMINAGA ,  Eiji NISHIYAMA ,  Nobuto KOYAMA ,  Takeshi SAKAI ,  Fu-Gong YU ,  Katsushige IKAI ,  Ikunoshin KATO

发明人： Tatsuji ENOKI ,  Hiroaki SAGAWA ,  Takanari TOMINAGA ,  Eiji NISHIYAMA ,  Nobuto KOYAMA ,  Takeshi SAKAI ,  Fu-Gong YU ,  Katsushige IKAI ,  Ikunoshin KATO

IPC分类号： A61K31/70 ,  A61K31/335

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.