公开(公告)号：US06284801B1

公开(公告)日：2001-09-04

申请号：US09380239

申请日：1999-08-27

申请人： Nobuto Koyama ,  Hua-Kang Wu ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Tatsuji Enoki ,  Hiromu Ohnogi ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hua-Kang Wu ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Tatsuji Enoki ,  Hiromu Ohnogi ,  Ikunoshin Kato

IPC分类号： A61K3112

CPC分类号： C07C323/59 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/122 ,  C07C45/60 ,  C07C45/78 ,  C07C49/707 ,  C07C323/58 ,  A23V2200/224 ,  A23V2250/5026 ,  A23V2250/5024 ,  A23V2250/21 ,  A23V2250/70 ,  A23V2250/06 ,  A23V2250/204

摘要： An antirheumatic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-l-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.

摘要翻译： 一种抗风湿剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为 有效成分。

公开(公告)号：US06177592B1

公开(公告)日：2001-01-23

申请号：US09341768

申请日：1999-07-16

申请人： Nobuto Koyama ,  Tatsuji Enoki ,  Katsushige Ikai ,  Hua-Kang Wu ,  Hiromu Ohnogi ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Hiroaki Sagawa ,  Hideto Chono ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Tatsuji Enoki ,  Katsushige Ikai ,  Hua-Kang Wu ,  Hiromu Ohnogi ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Hiroaki Sagawa ,  Hideto Chono ,  Ikunoshin Kato

IPC分类号： C07C6106

CPC分类号： C07C323/59 ,  A23K20/105 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/122 ,  C07C45/60 ,  C07C45/78 ,  C07C49/707 ,  C07C323/58 ,  C07C2601/08 ,  Y02A50/478 ,  A23V2200/224 ,  A23V2250/5026 ,  A23V2250/5024 ,  A23V2250/70 ,  A23V2250/204 ,  A23V2250/06 ,  A23V2250/21

摘要： A compound represented by the following formula [I] or an optically active substance or a salt thereof. (In the formula, a bond shown by a dotted line in the five-membered ring means that said five-membered ring may be any of a cyclopentene ring having a double bond and a cyclopentane ring where said bond is saturated and, in the case of a cyclopentene ring, X is OH, Y is ═O and Z is H while, in the case of a cyclopentane ring, X is ═O, Y is OH and Z is OH. R is a residue after removal of an SH group from the SH-containing compound.)

摘要翻译： 由下式[I]表示的化合物或光学活性物质或其盐（在该式中，五元环中虚线所示的键表示所述五元环可以是 具有双键的环戊烯环和所述键饱和的环戊烷环，在环戊烯环的情况下，X为OH，Y为= O且Z为H，而在环戊烷环的情况下，X为= O，Y是OH，Z是OH，R是从含SH的化合物除去SH基团后的残基。

公开(公告)号：US06482806B1

公开(公告)日：2002-11-19

申请号：US09125397

申请日：1998-08-18

申请人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： A61K31727

CPC分类号： C07H7/033 ,  A61K8/60 ,  A61Q11/00 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.

摘要翻译： 通过加热选自以下（a），（b）和（c）中的至少一种物质获得的产物：（a）糖醛酸或糖醛酸衍生物;（b）含有糖醛酸或含有糖醛酸的糖类化合物的糖类化合物 酸衍生物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质;以及含有上述热处理物的食品，饮料或药剂。

公开(公告)号：US20050202064A1

公开(公告)日：2005-09-15

申请号：US11114071

申请日：2005-04-26

申请人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： A23L3/3562 ,  A61K8/60 ,  A61K31/19 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/715 ,  A61K31/727 ,  A61K31/728 ,  A61K31/732 ,  A61K31/734 ,  A61K31/737 ,  A61K35/00 ,  A61K35/12 ,  A61K35/74 ,  A61K36/00 ,  A61L2/16 ,  A61P35/00 ,  A61Q11/00 ,  C07H7/033 ,  C08B37/00

CPC分类号： C07H7/033 ,  A61K8/60 ,  A61Q11/00 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.

摘要翻译： 通过加热至少一种选自以下（a），（b）和（c）的物质而得到的产物。 （a）糖醛酸或糖醛酸衍生物; （b）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质; 以及食品，饮料或药剂，其特征在于含有上述热处理产品。

公开(公告)号：US06194467B1

公开(公告)日：2001-02-27

申请号：US09367163

申请日：1999-08-09

申请人： Hua-Kang Wu ,  Nobuto Koyama ,  Eiji Nishiyama ,  Takanari Tominaga ,  Michio Hagiya ,  Ikunoshin Kato

发明人： Hua-Kang Wu ,  Nobuto Koyama ,  Eiji Nishiyama ,  Takanari Tominaga ,  Michio Hagiya ,  Ikunoshin Kato

IPC分类号： A61K3112

CPC分类号： C07C323/59 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/122 ,  C07C45/60 ,  C07C45/78 ,  C07C49/707 ,  C07C323/58 ,  Y10S514/866 ,  A23V2200/224 ,  A23V2250/5026 ,  A23V2250/5024 ,  A23V2250/06 ,  A23V2250/21 ,  A23V2250/204 ,  A23V2250/70

摘要： A therapeutic or preventive agent for diabetes mellitus which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.

摘要翻译： 一种糖尿病治疗或预防剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮和光学活性物质的化合物和 其盐作为有效成分。

公开(公告)号：US06548543B1

公开(公告)日：2003-04-15

申请号：US09763244

申请日：2001-02-20

申请人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31215

CPC分类号： A61K31/215 ,  A61K31/22 ,  C07C69/013 ,  C07C2601/10 ,  Y02A50/411

摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

摘要翻译： 需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要调节细胞的疾病 含有作为活性成分的至少一种选自通式[I]表示的环戊烯酮衍生物的化合物，其光学活性异构体和盐，其中R 1和R 2为 相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。

公开(公告)号：US06911432B2

公开(公告)日：2005-06-28

申请号：US10228195

申请日：2002-08-27

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A23L1/30 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A61K31/341 ,  C07G99/00 ,  A01N43/04

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I): These compositions include foods, drinks, cosmetics, etc. containing as the active ingredient at least one such compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. These compounds show an apoptosis-inducing activity, carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes them useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对3,6-脱水吡喃半乳糖敏感的疾病的药物组合物由式（I）表示：这些组合物包括含有至少一种这样的化合物，其醛， 其水合物和2-O-甲基化衍生物和含有上述化合物的可溶性糖化合物。 这些化合物对活性氧，脂质过氧化物自由基和NO的生成表现出细胞凋亡诱导活性，制癌活性和抑制活性，这使得它们也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US06475990B1

公开(公告)日：2002-11-05

申请号：US09554235

申请日：2000-05-11

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A01N4304

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US20090099101A1

公开(公告)日：2009-04-16

申请号：US12222492

申请日：2008-08-11

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31/70 ,  A61K31/335

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US06608032B1

公开(公告)日：2003-08-19

申请号：US09889732

申请日：2001-07-20

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Jun Tomono ,  Takanari Tominaga ,  Eiji Nishiyama ,  Hua-Kang Wu ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Jun Tomono ,  Takanari Tominaga ,  Eiji Nishiyama ,  Hua-Kang Wu ,  Ikunoshin Kato

IPC分类号： A01N4304

CPC分类号： A61K31/7048 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7024 ,  A61K31/7028 ,  C07H3/10 ,  C07H11/00 ,  C07H15/04 ,  Y02A50/411 ,  Y10S977/915

摘要： Medicinal compositions for treating or preventing diabetes, rheumatoid, diseases wherein inflammation should be inhibited, diseases wherein &agr;-glycosidase should be inhibited, diseases wherein the synthesis of prostaglandin should be inhibited, diseases wherein endotoxin shock should be inhibited, diseases wherein the production of interleukin should be inhibited, diseases wherein the production of heme oxygenase should be induced, and diseases wherein the production of tumor necrosis factor or carcinogenesis should be inhibited, which contain as the active ingredient at least one compound selected from the group consisting of 3,6-anhydrogalactopyranose represented by formula (I), its aldehyde, its hydrate and 2-O-methylated derivatives and 2-O-sulfated derivatives thereof.

摘要翻译： 用于治疗或预防糖尿病，类风湿病，其中应该抑制炎症的疾病的药物组合物，应该抑制α-糖苷酶的疾病，应该抑制前列腺素合成的疾病，应该抑制内毒素休克的疾病，其中产生白细胞介素 应该被抑制，其中应该诱导血红素加氧酶的产生的疾病，以及应该抑制肿瘤坏死因子或致癌作用的产生的疾病，其中含有选自下组的至少一种化合物作为活性成分： 由式（I）表示的脱水吡喃半乳糖，其醛，其水合物和2-O-甲基化衍生物及其2-O-硫酸化衍生物。