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1.发明申请Drugs, foods or drinks with the use of algae-derived physiologically active substances 审中-公开使用藻类来源的生理活性物质的药物，食品或饮料公开(公告)号：US20090099101A1
公开(公告)日：2009-04-16
申请号：US12222492
申请日：2008-08-11
Applicant: Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
Inventor： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
IPC: A61K31/70 , A61K31/335
CPC classification number: A01N43/04 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A23L33/105 , A61K31/341 , A61K31/7048
Abstract: Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.
Abstract translation: 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。
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公开(公告)号：US20090098600A1
公开(公告)日：2009-04-16
申请号：US12194364
申请日：2008-08-19
Applicant: Takashi Uemori , Yoshimi Sato , Nobuto Koyama , Ryo Hirano , Hikaru Takakura , Hiroshi Kobori , Yuji Hashimoto , Kikyozo Asada , Ikunoshin Kato
Inventor： Takashi Uemori , Yoshimi Sato , Nobuto Koyama , Ryo Hirano , Hikaru Takakura , Hiroshi Kobori , Yuji Hashimoto , Kikyozo Asada , Ikunoshin Kato
CPC classification number: C12N9/22
Abstract: Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
Abstract translation: 具有在遗传工程中非常有用的RNase H活性的多肽; 编码这些多肽的基因; 以及用于遗传工程化生产这些多肽的方法。
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公开(公告)号：US20080293141A1
公开(公告)日：2008-11-27
申请号：US11663990
申请日：2005-09-28
Applicant: Hideto Chono , Hiromi Okuyama , Tomoe Egashira , Nobuto Koyama , Junichi Mineno , Ikunoshin Kato
Inventor： Hideto Chono , Hiromi Okuyama , Tomoe Egashira , Nobuto Koyama , Junichi Mineno , Ikunoshin Kato
CPC classification number: C12N9/1051 , C12N15/86 , C12N2740/13043 , C12N2740/13052 , C12N2799/02 , C12N2810/10
Abstract: The N-acetylglucosaminyltransferase III activity is enhanced in a cell carrying retrovirus-origin gag-pol gene and env gene. By constructing a retrovirus vector with the use of the above cell, a retrovirus vector having a modified sugar chain structure can be obtained. The retrovirus vector constructed by this method shows a high infection efficiency particularly in the presence of a functional substance.
Abstract translation: 在携带逆转录病毒起始gag-pol基因和env基因的细胞中N-乙酰葡糖胺基转移酶III活性增强。 通过使用上述细胞构建逆转录病毒载体，可以获得具有修饰的糖链结构的逆转录病毒载体。 通过该方法构建的逆转录病毒载体特别是在功能性物质存在下显示高感染效率。
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4.发明授权Methods and kits for improving retroviral-mediated gene transfer utilizing molecules, or mixture thereof, containing retroviral binding domains and target cell binding domains 失效使用含有逆转录病毒结合结构域和靶细胞结合结构域的分子或其混合物来改进逆转录病毒介导的基因转移的方法和试剂盒公开(公告)号：US06426042B1
公开(公告)日：2002-07-30
申请号：US09366009
申请日：1999-08-02
Applicant: Kiyozo Asada , Takashi Uemori , Takashi Ueno , Nobuto Koyama , Kimikazu Hashino , Ikunoshin Kato
Inventor： Kiyozo Asada , Takashi Uemori , Takashi Ueno , Nobuto Koyama , Kimikazu Hashino , Ikunoshin Kato
IPC: G01N3122
CPC classification number: C12N15/86 , A61K48/00 , C07K14/505 , C07K14/78 , C07K2319/00 , C12N9/1088 , C12N2740/13043 , C12N2740/13045
Abstract: The present invention provides a kit to carry out retrovirus-mediated gene transfer into target cells. The kit contains a functional material bearing a retrovirus binding domain, another functional material bearing a target cell binding domain, an artificial substrate for incubating the retrovirus contacted with the target cells, and a target cell growth factor for pre-stimulating target cells to spur them along the cell cycle. The kit of the invention may further comprise a recombinant retroviral vector, necessary buffers, and the like.
Abstract translation: 本发明提供了一种用于将逆转录病毒介导的基因转移进入靶细胞的试剂盒。 该试剂盒包含具有逆转录病毒结合结构域的功能材料，具有靶细胞结合结构域的另一功能材料，用于孵育与靶细胞接触的逆转录病毒的人造底物，以及用于预刺激靶细胞刺激它们的靶细胞生长因子 沿细胞周期。 本发明的试剂盒还可以包含重组逆转录病毒载体，必需的缓冲液等。
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公开(公告)号：US06326405B1
公开(公告)日：2001-12-04
申请号：US09443089
申请日：1999-11-18
Applicant: Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato
Inventor： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato
IPC: A61K3112
CPC classification number: C07C45/60 , A61K31/12 , A61K31/122 , C07C45/71 , C07C49/707 , C07C49/753
Abstract: An anticancer agent in which 4-cyclopentene-1,3-dione represented by the following formula [I] and/or 4-hydroxy-2-cyclopentenone represented by the following formula [II] are/is effective component(s).
Abstract translation: 由下式[I]表示的4-环戊烯-1,3-二酮和/或下式[II]表示的4-羟基-2-环戊烯酮的抗癌剂为有效成分。
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Patent Agency Ranking
公开(公告)号：US06284801B1
公开(公告)日：2001-09-04
申请号：US09380239
申请日：1999-08-27
Applicant: Nobuto Koyama , Hua-Kang Wu , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Tatsuji Enoki , Hiromu Ohnogi , Ikunoshin Kato
Inventor： Nobuto Koyama , Hua-Kang Wu , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Tatsuji Enoki , Hiromu Ohnogi , Ikunoshin Kato
IPC: A61K3112
CPC classification number: C07C323/59 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/122 , C07C45/60 , C07C45/78 , C07C49/707 , C07C323/58 , A23V2200/224 , A23V2250/5026 , A23V2250/5024 , A23V2250/21 , A23V2250/70 , A23V2250/06 , A23V2250/204
Abstract: An antirheumatic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-l-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
Abstract translation: 一种抗风湿剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为 有效成分。
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公开(公告)号：US5434245A
公开(公告)日：1995-07-18
申请号：US993980
申请日：1992-12-16
Applicant: Nobuto Koyama , Fusao Kimizuka , Ikunoshin Kato
Inventor： Nobuto Koyama , Fusao Kimizuka , Ikunoshin Kato
IPC: C12P21/02 , A61K38/00 , A61P3/02 , A61P37/00 , A61P43/00 , C07K1/22 , C07K14/00 , C07K14/51 , C07K14/52 , C07K14/78 , C07K19/00 , C12N15/09 , C12N15/12 , C12P21/06 , C12R1/19 , C07K14/47 , C07K14/70
CPC classification number: C07K14/78
Abstract: There is provided a polypeptide having the following formula (I'), and which polypeptide is referred to as Glu-OC and a process for the preparation thereof. ##STR1##
Abstract translation: 提供具有下式（I'）的多肽，该多肽称为Glu-OC及其制备方法。
（I'） -
8.发明授权Method for producing retrovirus using human producer cells with increased N-acetylglucosaminyltransferase III activity 有权使用具有增加的N-乙酰葡糖胺基转移酶III活性的人生产细胞产生逆转录病毒的方法公开(公告)号：US09057056B2
公开(公告)日：2015-06-16
申请号：US11663990
申请日：2005-09-28
Applicant: Hideto Chono , Hiromi Okuyama , Tomoe Egashira , Nobuto Koyama , Junichi Mineno , Ikunoshin Kato
Inventor： Hideto Chono , Hiromi Okuyama , Tomoe Egashira , Nobuto Koyama , Junichi Mineno , Ikunoshin Kato
CPC classification number: C12N9/1051 , C12N15/86 , C12N2740/13043 , C12N2740/13052 , C12N2799/02 , C12N2810/10
Abstract: The N-acetylglucosaminyltransferase III activity is enhanced in a cell carrying retrovirus-origin gag-pol gene and env gene. By constructing a retrovirus vector with the use of the above cell, a retrovirus vector having a modified sugar chain structure can be obtained. The retrovirus vector constructed by this method shows a high infection efficiency particularly in the presence of a functional substance.
Abstract translation: 在携带逆转录病毒起始gag-pol基因和env基因的细胞中N-乙酰葡糖胺基转移酶III活性增强。 通过使用上述细胞构建逆转录病毒载体，可以获得具有修饰的糖链结构的逆转录病毒载体。 通过该方法构建的逆转录病毒载体特别是在功能性物质存在下显示高感染效率。
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公开(公告)号：US08008055B2
公开(公告)日：2011-08-30
申请号：US12194364
申请日：2008-08-19
Applicant: Takashi Uemori , Yoshimi Sato , Nobuto Koyama , Ryo Hirano , Hikaru Takakura , Hiroshi Kobori , Yuji Hashimoto , Kikyozo Asada , Ikunoshin Kato
Inventor： Takashi Uemori , Yoshimi Sato , Nobuto Koyama , Ryo Hirano , Hikaru Takakura , Hiroshi Kobori , Yuji Hashimoto , Kikyozo Asada , Ikunoshin Kato
CPC classification number: C12N9/22
Abstract: Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
Abstract translation: 具有在遗传工程中非常有用的RNase H活性的多肽; 编码这些多肽的基因; 以及用于遗传工程化生产这些多肽的方法。
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公开(公告)号：US08003781B2
公开(公告)日：2011-08-23
申请号：US12281601
申请日：2007-03-02
Applicant: Akihiro Kondo , Wenzhe Li , Takatoshi Nakagawa , Nobuto Koyama , Naoyuki Taniguchi , Ikunoshin Kato
Inventor： Akihiro Kondo , Wenzhe Li , Takatoshi Nakagawa , Nobuto Koyama , Naoyuki Taniguchi , Ikunoshin Kato
CPC classification number: C12N15/1137 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12Y204/01068
Abstract: Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.
Abstract translation: 公开了减少FUT8基因的表达量，降低FUT8蛋白的表达量和/或降低由FUT8的作用产生的产物的表达量的方法。
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