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公开(公告)号：US06207652B1
公开(公告)日：2001-03-27
申请号：US09051284
申请日：1998-04-09
申请人： Takeshi Sakai , Hideo Kitano , Fu-Gong Yu , Shinji Nakayama , Kaoru Kojima , Hitomi Kimura , Yoshikuni Nakanishi , Kaoru Katayama , Takanari Tominaga , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
发明人： Takeshi Sakai , Hideo Kitano , Fu-Gong Yu , Shinji Nakayama , Kaoru Kojima , Hitomi Kimura , Yoshikuni Nakanishi , Kaoru Katayama , Takanari Tominaga , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31715
CPC分类号： C12Y302/01078 , A61K31/737 , C12N9/2494 , C12P19/14 , C12Y302/01044
摘要： Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.
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公开(公告)号：US5200505A
公开(公告)日：1993-04-06
申请号：US643948
申请日：1991-01-22
申请人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
发明人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
IPC分类号： C12N1/14 , A61K38/00 , A61P31/04 , C07K1/20 , C07K7/06 , C07K11/02 , C07K14/195 , C07K14/37 , C07K14/41 , C12P21/02 , C12R1/645
CPC分类号： C07K11/02
摘要： There are provided R106 compounds represented by the following general formula (I): ##STR1## wherein: A.sub.1 is Phe, o-FPhe, m-FPhe, or Tyr;A.sub.2 is MePhe, o-FMePhe, m-FMePhe, MeTyr, Sar, MeSery, or .beta.-oxoMePhe;A.sub.3 is Pro, 4Hyp, or SPro;A.sub.4 is allo-Ile or Nle;A.sub.5 is Leu or Nva;A.sub.6 is .beta.-HOMeVal or Sar;excluding those wherein A.sub.1 is Phe and A.sub.2 is MePhe and A.sub.3 is Pro and A.sub.4 is allo-Ile and A.sub.5 is Leu and A.sub.6 is .beta.-HOMeVal (SEQ ID No. 4), which are useful as therapeutic agents for fungal infection.
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公开(公告)号：US07125984B2
公开(公告)日：2006-10-24
申请号：US10258133
申请日：2001-04-19
申请人： Takeshi Sakai , Kumiko Ishizuka , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
发明人： Takeshi Sakai , Kumiko Ishizuka , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
CPC分类号： C12Y302/01139 , C08B37/00 , C08B37/006 , C12N9/2402 , C12P19/14 , C12R1/01 , C12Y302/01044
摘要： Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.
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公开(公告)号：US06927289B2
公开(公告)日：2005-08-09
申请号：US10694352
申请日：2003-10-28
申请人： Takeshi Sakai , Hitomi Amarume , Takashi Kawai , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
发明人： Takeshi Sakai , Hitomi Amarume , Takashi Kawai , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
CPC分类号： C08B37/006
摘要： A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.
摘要翻译： 通过使来自属于层状藻酸盐的藻类的新型硫酸化多糖消化的硫酸化的岩藻糖消化酶作用于硫酸化的岩藻石上的小分子及其制造方法。
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公开(公告)号：US06337410B2
公开(公告)日：2002-01-08
申请号：US09731041
申请日：2000-12-07
IPC分类号： C07D31500
CPC分类号： C07D313/00 , C12P17/08
摘要： The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases. The present invention is related to an antibiotic TKR459 having the following chemical formula (1) or its pharmacologically acceptable salt.
摘要翻译： 本发明的目的是提供一种在真菌感染性疾病的治疗中用作临床药物的贵重抗真菌物质。本发明涉及具有以下化学式（1）或其药理学上可接受的盐的抗生素TKR459。
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6.发明授权Process for the production of antibiotic R106 by a strain of Aureobasidium pullulans 失效抗生素R106的制备方法，由抗生素短杆菌（Aureobasidium pullulans）生产
公开(公告)号：US5158876A
公开(公告)日：1992-10-27
申请号：US657811
申请日：1991-02-02
申请人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
发明人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
摘要： An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.
摘要翻译： 由通式（I）表示的抗生素R106：其中：R是甲基或乙基; X1是MePhe，β-HOMePhe或Phe; X2是异亮氨酸，Val或Leu; X3是MeVal或Val; X4是β-HOMeVal，γHOMeVal，MeVal，Val，N，β-MeAsp，β-HOMePhe，MePhe，MeDH2,3Val或MeDH3,4Val是通过包括培养能够产生的Aureobasidium属的菌株 产生所述抗生素R106并从发酵液中收集所述抗生素。 抗生素R106化合物可用于治疗真菌感染。
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公开(公告)号：US20080038289A1
公开(公告)日：2008-02-14
申请号：US11596395
申请日：2005-05-30
申请人： Takashi Kawai , Shigetoshi Mizutani , Tatsuji Enoki , Hiroaki Sagawa , Takeshi Sakai , Kazuo Shimanaka , Ikunoshin Kato
发明人： Takashi Kawai , Shigetoshi Mizutani , Tatsuji Enoki , Hiroaki Sagawa , Takeshi Sakai , Kazuo Shimanaka , Ikunoshin Kato
IPC分类号： A61K36/06 , A61K31/045 , A61P35/00
CPC分类号： A61K36/07 , A23L33/105 , A61K31/047
摘要： According to the present invention, an antitumor agent, an apoptosis-inducing agent or an angiogenesis-suppressing agent having the effect even via an oral route, containing a compound contained in an inexpensive edible basidiomycete or a composition derived from an edible basidiomycete, and a food having the antitumor activity, the apoptosis-inducing activity or the angiogenesis-suppressing activity containing the compound or the composition can be obtained. Therefore, the present invention is particularly useful, especially in the field of a medicine and a health food.
摘要翻译： 根据本发明，通过口服途径具有效果的抗肿瘤剂，细胞凋亡诱导剂或血管生成抑制剂，其含有廉价的可食用担子菌或含有可食用担子菌的组合物，以及 可以获得具有抗肿瘤活性，含有化合物或组合物的细胞凋亡诱导活性或血管生成抑制活性的食品。 因此，本发明特别有用，特别是在药物和保健食品领域。
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公开(公告)号：US20060166335A1
公开(公告)日：2006-07-27
申请号：US11373989
申请日：2006-03-14
申请人： Takeshi Sakai , Kumiko Ishizuka , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
发明人： Takeshi Sakai , Kumiko Ishizuka , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
CPC分类号： C12Y302/01139 , C08B37/00 , C08B37/006 , C12N9/2402 , C12P19/14 , C12R1/01 , C12Y302/01044
摘要： Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.
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公开(公告)号：US06593311B2
公开(公告)日：2003-07-15
申请号：US09770504
申请日：2001-01-29
申请人： Takeshi Sakai , Hideo Kitano , Fu-Gong Yu , Shinji Nakayama , Kaoru Kojima , Hitomi Kimura , Yoshikuni Nakanishi , Kaoru Katayama , Takanari Tominaga , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
发明人： Takeshi Sakai , Hideo Kitano , Fu-Gong Yu , Shinji Nakayama , Kaoru Kojima , Hitomi Kimura , Yoshikuni Nakanishi , Kaoru Katayama , Takanari Tominaga , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31715
CPC分类号： C12Y302/01078 , A61K31/737 , C12N9/2494 , C12P19/14 , C12Y302/01044
摘要： Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.
摘要翻译： 含有硫酸化岩藻糖的多糖和/或其降解产物的细胞凋亡诱导剂，抗癌药和抗癌药以及使用含有硫酸化岩藻糖的多糖和/或降解产物诱导细胞凋亡的方法 作为活性成分。 一种可用于生产含硫酸化岩藻糖多糖的降解产物的降解酶。
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公开(公告)号：US06720419B2
公开(公告)日：2004-04-13
申请号：US10278942
申请日：2002-10-24
申请人： Takeshi Sakai , Hitomi Amarume , Takashi Kawai , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
发明人： Takeshi Sakai , Hitomi Amarume , Takashi Kawai , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
IPC分类号： C08B3700
CPC分类号： C08B37/006
摘要： A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.
摘要翻译： 通过使来自属于层状藻酸盐的藻类的新型硫酸化多糖消化的硫酸化的岩藻糖消化酶作用于硫酸化的岩藻石上的小分子及其制造方法。
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