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1.发明申请MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 有权具有替代功能的多特异性抗原结合分子对血液凝血因子VIII的功能公开(公告)号：US20130330345A1
公开(公告)日：2013-12-12
申请号：US13885421
申请日：2011-11-17
申请人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
发明人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译： 各种双特异性抗体特异性结合血液凝固因子IX /活化血液凝固因子IX和血液凝固因子X，并功能取代血液凝固因子VIII的辅因子功能，即促进凝血因子X活化的功能 活化血液凝固因子IX。 从这些抗体中，成功发现了具有高功能取代凝血因子VIII活性的多特异性抗原结合分子。
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公开(公告)号：US08062638B1
公开(公告)日：2011-11-22
申请号：US10089501
申请日：2000-09-29
IPC分类号： A61K39/395 , C07K14/745 , C07K16/24
CPC分类号： G01N33/5008 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/106 , A01K2267/03 , A61K2039/505 , C07K16/36 , C07K2317/24 , C07K2319/00 , C12N15/8509 , G01N33/502 , G01N33/5094
摘要： Provided herein is an animal having a persistent hypercoagulable state by implanting a cell, for example a tumor cell, in which the gene of human tissue factor is implanted to an experimental animal such as a mouse and then growing the cell, thereby persistently supplying human tissue factor to the experimental animal. This animal model is useful for research and development of therapeutic agents for diseases having a persistent hypercoagulable state. Also provided are preventive or therapeutic agents for diseases having a persistent hypercoagulable state, a hypercoagulable state resulting from infections, venous thrombosis, arterial thrombosis, and diseases resulting from the hypertrophy of vascular media, the agent comprising an antibody against human tissue factor (human TF) as an active ingredient.
摘要翻译： 本文提供了一种具有持续性高凝状态的动物，其通过将例如肿瘤细胞植入细胞，其中将人组织因子的基因植入到诸如小鼠的实验动物中，然后使细胞生长，从而持续地供应人体组织 因子到实验动物。 该动物模型对于具有持续性高凝状态的疾病的治疗剂的研究和开发是有用的。 还提供了用于具有持续性高凝状态，由感染引起的高凝状态，静脉血栓形成，动脉血栓形成和由血管介质肥大引起的疾病的疾病的预防或治疗剂，所述药物包含针对人组织因子的抗体（人TF ）作为活性成分。
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公开(公告)号：US09334331B2
公开(公告)日：2016-05-10
申请号：US13885421
申请日：2011-11-17
申请人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
发明人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译： 各种双特异性抗体特异性结合血液凝固因子IX /活化血液凝固因子IX和血液凝固因子X，并功能取代血液凝固因子VIII的辅因子功能，即促进凝血因子X活化的功能 活化血液凝固因子IX。 从这些抗体中，成功发现了具有高功能取代凝血因子VIII活性的多特异性抗原结合分子。
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公开(公告)号：US09175091B2
公开(公告)日：2015-11-03
申请号：US12742947
申请日：2008-11-14
CPC分类号： C07K16/32 , A01K2267/0331 , A61K2039/505 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/30
摘要： The present inventors have succeeded in producing anti-AXL antibodies with specific functions. The present inventors also discovered that the antibodies have an angiogenesis-suppressive effect and an antitumor effect, and thereby completed the present invention. The anti-AXL antibodies of the present invention are useful as angiogenesis inhibitors and agents for inducing or inhibiting phosphorylation activity.
摘要翻译： 本发明人成功地制备了具有特定功能的抗AXL抗体。 本发明人还发现，抗体具有血管发生抑制作用和抗肿瘤作用，从而完成了本发明。 本发明的抗AXL抗体可用作血管生成抑制剂和诱导或抑制磷酸化活性的药剂。
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公开(公告)号：US20120073002A1
公开(公告)日：2012-03-22
申请号：US13252455
申请日：2011-10-04
CPC分类号： G01N33/5008 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/106 , A01K2267/03 , A61K2039/505 , C07K16/36 , C07K2317/24 , C07K2319/00 , C12N15/8509 , G01N33/502 , G01N33/5094
摘要： Provided herein is an animal having a persistent hypercoagulable state by implanting a cell, for example a tumor cell, in which the gene of human tissue factor is implanted to an experimental animal such as a mouse and then growing the cell, thereby persistently supplying human tissue factor to the experimental animal. This animal model is useful for research and development of therapeutic agents for diseases having a persistent hypercoagulable state. Also provided are preventive or therapeutic agents for diseases having a persistent hypercoagulable state, a hypercoagulable state resulting from infections, venous thrombosis, arterial thrombosis, and diseases resulting from the hypertrophy of vascular media, the agent comprising an antibody against human tissue factor (human TF) as an active ingredient.
摘要翻译： 本文提供了一种具有持续性高凝状态的动物，其通过将例如肿瘤细胞植入细胞，其中将人组织因子的基因植入到诸如小鼠的实验动物中，然后使细胞生长，从而持续地供应人体组织 因子到实验动物。 该动物模型对于具有持续性高凝状态的疾病的治疗剂的研究和开发是有用的。 还提供了用于具有持续性高凝状态，由感染引起的高凝状态，静脉血栓形成，动脉血栓形成和由血管介质肥大引起的疾病的疾病的预防或治疗剂，所述药物包含针对人组织因子的抗体（人TF ）作为活性成分。
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6.发明申请公开(公告)号：US20110044984A1
公开(公告)日：2011-02-24
申请号：US12742947
申请日：2008-11-14
IPC分类号： A61K39/395 , C07K16/32 , C12N5/00 , A61P35/00
CPC分类号： C07K16/32 , A01K2267/0331 , A61K2039/505 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/30
摘要： The present inventors have succeeded in producing anti-AXL antibodies with specific functions. The present inventors also discovered that the antibodies have an angiogenesis-suppressive effect and an antitumor effect, and thereby completed the present invention. The anti-AXL antibodies of the present invention are useful as angiogenesis inhibitors and agents for inducing or inhibiting phosphorylation activity.
摘要翻译： 本发明人成功地制备了具有特定功能的抗AXL抗体。 本发明人还发现，抗体具有血管发生抑制作用和抗肿瘤作用，从而完成了本发明。 本发明的抗AXL抗体可用作血管生成抑制剂和诱导或抑制磷酸化活性的药剂。
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7.发明申请Agent neutralizint tissue factor inhibitor and agent neutralizing activated blood coagulation factor viii preparation 审中-公开药剂中和组织因子抑制剂和药剂中和活化凝血因子viii制剂公开(公告)号：US20060233786A1
公开(公告)日：2006-10-19
申请号：US10513491
申请日：2003-05-23
IPC分类号： A61K39/395
CPC分类号： A61K38/57 , A61K38/4846 , A61K2300/00
摘要： Formulations for neutralizing the anticoagulant action of a human tissue factor inhibitor, comprising a blood coagulation factor complex product or an activated blood coagulation factor VII product as an active ingredient; and formulations for neutralizing the blood coagulation-promoting action of an activated blood coagulation factor VII product, comprising a human tissue factor inhibitor as an active ingredient.
摘要翻译： 用于中和人组织因子抑制剂的抗凝血作用的制剂，其包含凝血因子复合物产品或活化凝血因子VII产物作为活性成分; 以及用于中和包含人组织因子抑制剂作为活性成分的活化凝血因子VII产物的促凝血作用的制剂。
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