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    Method for monitoring the effectiveness of teracycline in the treatment of asthma
    6.
    发明申请
    Method for monitoring the effectiveness of teracycline in the treatment of asthma 审中-公开
    监测万古霉素治疗哮喘有效性的方法

    公开(公告)号：US20060128675A1

    公开(公告)日：2006-06-15

    申请号：US10523856

    申请日：2003-08-08

    申请人： Helen Durkin ,  Rauno Joks ,  Tamar Smith-Norowitz ,  Martin Bluth

    发明人： Helen Durkin ,  Rauno Joks ,  Tamar Smith-Norowitz ,  Martin Bluth

    IPC分类号： A61K31/65

    CPC分类号： G01N33/6854 ,  A61K31/65 ,  G01N2800/122 ,  G01N2800/52 ,  A61K2300/00

    摘要： The present invention is directed to a method of lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic which method comprises administering to said mammal an IgE lowering effective amount of a tetracycline such as minocycline or doxycline. It is also directed to a method of monitoring the effectiveness of a drug in lowering the concentration of excess IgE in plasma in a mammal suffering from the disease in which IgE is pathogenic which method comprises making a first determination of the concentration of IgE in the plasma of said mammal at an initial time; administering to said mammal the drug; making a second determination of the concentration of IgE in the plasma of said mammal after the initial time and after administration of the drug and comparing the values obtained from the first and second determinations, such that if the value of the second determination is higher than or about the same as the value of the first determination and above a threshold level, then the dosage amount of the drug administered to the mammal is increased; otherwise the dosage amount is maintained.

    摘要翻译： 本发明涉及一种降低患有IgE致病性疾病的哺乳动物中过量IgE水平的方法，该方法包括向所述哺乳动物施用降低有效量的四环素如米诺环素或多西环素的IgE。 还涉及一种监测药物在降低IgE致病性疾病的哺乳动物中血浆中过量IgE浓度降低的有效性的方法，该方法包括首先测定血浆中IgE的浓度 的哺乳动物; 向所述哺乳动物施用所述药物; 在所述哺乳动物的初始时间和给药后第二次测定所述哺乳动物血浆中IgE的浓度，并比较从第一次和第二次测定得到的值，使得如果第二次测定的值高于或 与第一次测定的值相同且高于阈值水平，则给予哺乳动物的药物的给药量增加; 否则维持剂量。