公开(公告)号：US20070166823A1

公开(公告)日：2007-07-19

申请号：US10555958

申请日：2004-05-05

申请人： Tamar Smith-Norowitz ,  Kevin Norowitz ,  Martin Bluth ,  Helen Durkin

发明人： Tamar Smith-Norowitz ,  Kevin Norowitz ,  Martin Bluth ,  Helen Durkin

IPC分类号： C12Q1/68 ,  C12N5/06 ,  C12N5/16

CPC分类号： G01N33/56983 ,  G01N2333/015 ,  G01N2469/20

摘要： The present invention provides a method for diagnosing a subject suffering a pathological condition characterized by parvovirus infection by detecting the presence of IgE anti-Parvovirus B 19 antibodies.

摘要翻译： 本发明提供了通过检测IgE抗细小病毒B19抗体的存在来诊断患有细小病毒感染特征性病理状况的受试者的方法。

公开(公告)号：US20060128675A1

公开(公告)日：2006-06-15

申请号：US10523856

申请日：2003-08-08

申请人： Helen Durkin ,  Rauno Joks ,  Tamar Smith-Norowitz ,  Martin Bluth

发明人： Helen Durkin ,  Rauno Joks ,  Tamar Smith-Norowitz ,  Martin Bluth

IPC分类号： A61K31/65

CPC分类号： G01N33/6854 ,  A61K31/65 ,  G01N2800/122 ,  G01N2800/52 ,  A61K2300/00

摘要： The present invention is directed to a method of lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic which method comprises administering to said mammal an IgE lowering effective amount of a tetracycline such as minocycline or doxycline. It is also directed to a method of monitoring the effectiveness of a drug in lowering the concentration of excess IgE in plasma in a mammal suffering from the disease in which IgE is pathogenic which method comprises making a first determination of the concentration of IgE in the plasma of said mammal at an initial time; administering to said mammal the drug; making a second determination of the concentration of IgE in the plasma of said mammal after the initial time and after administration of the drug and comparing the values obtained from the first and second determinations, such that if the value of the second determination is higher than or about the same as the value of the first determination and above a threshold level, then the dosage amount of the drug administered to the mammal is increased; otherwise the dosage amount is maintained.

摘要翻译： 本发明涉及一种降低患有IgE致病性疾病的哺乳动物中过量IgE水平的方法，该方法包括向所述哺乳动物施用降低有效量的四环素如米诺环素或多西环素的IgE。 还涉及一种监测药物在降低IgE致病性疾病的哺乳动物中血浆中过量IgE浓度降低的有效性的方法，该方法包括首先测定血浆中IgE的浓度 的哺乳动物; 向所述哺乳动物施用所述药物; 在所述哺乳动物的初始时间和给药后第二次测定所述哺乳动物血浆中IgE的浓度，并比较从第一次和第二次测定得到的值，使得如果第二次测定的值高于或 与第一次测定的值相同且高于阈值水平，则给予哺乳动物的药物的给药量增加; 否则维持剂量。

公开(公告)号：US20060235081A1

公开(公告)日：2006-10-19

申请号：US10544814

申请日：2004-02-09

申请人： Helen Durkin ,  Martin Bluth ,  Tamar Smith-Norowitz ,  Rauno Joks ,  Alexander Kiselyov

发明人： Helen Durkin ,  Martin Bluth ,  Tamar Smith-Norowitz ,  Rauno Joks ,  Alexander Kiselyov

IPC分类号： A61K31/16 ,  A61K31/13 ,  A61K31/12 ,  C07C237/18

CPC分类号： C07C49/835 ,  C07C225/20 ,  C07C237/24 ,  C07C2601/16 ,  C07C2602/28 ,  C07C2603/24

摘要： The present invention is directed novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.

摘要翻译： 本发明涉及作为二甲胺四环素或多西环素的衍生物的新型化合物，含有它们的药物组合物及其在降低IgE致病性疾病的哺乳动物中降低过量IgE水平的用途。