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公开(公告)号：US08454655B2
公开(公告)日：2013-06-04
申请号：US12803110
申请日：2010-06-19
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0467 , A61B2017/00805 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0437 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61B2090/062
摘要： An elastically curved suture anchor is resiliently straightened and delivered into tissue by a needle. When the needle is withdrawn, resumption of the curvature provides leverage for anchor rotation as the attached suture is pulled to fasten the anchor within the tissue. A fin at the proximal end of the anchor further increases the rotational leverage and expedites anchor fastening. When two or more anchors with connecting suture are delivered in series on a needle, the tension of the suture helps to draw the anchors together and approximates the pierced tissue.
摘要翻译： 弹性弯曲的缝合锚固件被弹性地拉直并通过针递送到组织中。 当针被取出时，恢复曲率提供锚定旋转的杠杆作用，因为所附连接的缝合线被拉紧以将锚固件固定在组织内。 在锚的近端处的翅片进一步增加旋转杠杆并加快锚固。 当具有连接缝合线的两个或多个锚固件被串联地递送到针上时，缝合线的张力有助于将锚固件拉到一起并且近似穿刺的组织。
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公开(公告)号：US08361007B2
公开(公告)日：2013-01-29
申请号：US12223370
申请日：2007-02-05
申请人： Jeffrey E. Yeung , Teresa T. Yeung
发明人： Jeffrey E. Yeung , Teresa T. Yeung
CPC分类号： A61B17/06066 , A61B17/062 , A61B17/1615 , A61B17/1671 , A61B17/7061 , A61B2017/061 , A61B2017/90 , A61F2002/444 , A61L27/28 , A61L2430/38
摘要： The intervertebral disc contains no blood vessels. Nutrients and waste are diffused mainly through adjacent vertebral bodies. As we age, calcified layers form between the disc and vertebral bodies, blocking diffusion. The disc begins to starve and flatten. The weight shifts abnormally from disc to the facet joints causing strain and back pain. Under anaerobic conditions, lactic acid is produced causing acidic irritation and unspecific pain. A U-shaped disc shunt (126) is delivered into and sealed within the degenerated disc simply by needle puncturing and withdrawal, to draw nutrients from bodily circulation into the avascular disc. A continual supply of nutrients increases biosynthesis of the water-retaining sulfated glycosaminoglycans, hence swelling pressure within the disc. The weight is re-shifted from the facet joints to the regenerated disc, alleviating back pain. With oxygen transported through the shunt, anaerobic production of lactic acid is minimized. In addition, the residual lactic acid is expelled through the U-shaped shunt during disc compression into bodily circulation to alleviate unspecific pain.
摘要翻译： 椎间盘不含血管。 营养物和废物主要通过相邻的椎体扩散。 随着年龄的增长，钙化层形成在椎间盘和椎体之间，阻止扩散。 光盘开始变得饿死了。 重量从椎间盘异常移动到小关节，引起应变和背部疼痛。 在厌氧条件下，产生乳酸，引起酸性刺激和非特异性疼痛。 U型盘分流器（126）通过针穿刺和抽出而被简单地输送并且在退化的盘中被密封，从而将营养物质从身体循环中吸收到无血管盘中。 持续供应营养物质可增加保水性硫酸糖胺聚糖的生物合成，从而增加盘内的压力。 重量从小关节重新转移到再生椎间盘，减轻背痛。 通过分流运送的氧气，乳酸的厌氧生产被最小化。 另外，残留的乳酸通过U形分流在椎间盘压迫期间被排出到身体循环中以减轻非特异性疼痛。
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公开(公告)号：US20120065570A1
公开(公告)日：2012-03-15
申请号：US13199906
申请日：2011-09-12
申请人： Jeffrey E. Yeung , Teresa T. Yeung , Andrew Yeung
发明人： Jeffrey E. Yeung , Teresa T. Yeung , Andrew Yeung
IPC分类号： A61M1/00
CPC分类号： A61B17/3468 , A61B17/7061
摘要： A solid stepped needle delivers a disc shunt bridging between muscle and a degenerated disc, drawing blood plasma from muscle into the degenerated disc to alleviate back pain and regenerate the disc. The device further includes pull lines attached to the ends of the disc shunt for withdrawing and repositioning the stepped needle during shunt delivery.
摘要翻译： 固定的步进式针头在肌肉和退化椎间盘之间提供桥接分离器，将血浆从肌肉吸入退化椎间盘以减轻背部疼痛并再生椎间盘。 该装置还包括附接到盘分路的端部的拉线，用于在分流输送期间抽出和重新定位阶梯式针。
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公开(公告)号：US08088150B2
公开(公告)日：2012-01-03
申请号：US12322570
申请日：2009-02-04
申请人： Jeffrey E. Yeung , Teresa T. Yeung
发明人： Jeffrey E. Yeung , Teresa T. Yeung
IPC分类号： A61B17/88
CPC分类号： A61B17/3468 , A61B17/3472 , A61B17/7061
摘要： A Quincke tipped introducer needle contains two shafts with lumens, one recessed, both connected by a slit for housing a U- or V-shaped disc shunt. The recessed shaft minimizes the penetration size of the introducer needle for insertion into a narrow and nerve laden space adjacent to a degenerated intervertebral disc. The longitudinal slit connecting the two lumens allows passage of the distal portion of the U-shaped disc shunt through the introducer needle, to be delivered into the intervertebral disc.Pain emitting from the avascular disc is extremely difficult to treat due to lack of penetration or permeability of drug. The lumens of the introducer needle are also used to retain a peri-shunt injectable into the disc shunt for delivery into the painful disc. The peri-shunt injectable can be an analgesic, narcotic, anti-inflammatory drug, antibiotic, anticonvulsant, antidepressant, buffer agent or alkaline agent to alleviate pain. The peri-shunt injectable can also be a nerve toxin retained within the lumens to be loaded within the shunt for terminating transmission of pain signal emitting from the disc.
摘要翻译： 一个Quincke尖头的导引针包含两个带腔的轴，一个凹进，一个凹进，两个通过用于容纳U形或V形盘分流的狭缝连接。 凹入的轴使导引针的穿透尺寸最小化，用于插入到与退化的椎间盘相邻的狭窄和神经负载的空间中。 连接两个流明的纵向狭缝允许U形盘分流的远端部分通过导引针通过，以被输送到椎间盘中。 从无血管盘发射的疼痛由于缺乏药物渗透或渗透性而难以治疗。 导引针的腔也用于将可分注的分流器保持在盘分流器中，以便输送到疼痛盘中。 分注注射剂可以是镇痛药，麻醉药，抗炎药，抗生素，抗惊厥药，抗抑郁药，缓冲剂或碱剂以缓解疼痛。 分注注射剂也可以是保留在腔内的神经毒素，以装载在分流器内，用于终止从盘发射的疼痛信号的传播。
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公开(公告)号：US20110029016A1
公开(公告)日：2011-02-03
申请号：US12924817
申请日：2010-10-05
申请人： Jeffrey E. Yeung , Teresa T. Yeung
发明人： Jeffrey E. Yeung , Teresa T. Yeung
IPC分类号： A61B17/064
CPC分类号： A61B17/0642 , A61B17/0401 , A61B17/0643 , A61B17/0644 , A61B17/0682 , A61B17/86 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/0438 , A61B2017/044 , A61B2017/0445 , A61B2017/0646 , A61B2017/0647 , A61B2017/0648 , A61F2/0805 , A61F2/0811 , A61F2002/0835 , A61F2002/0841 , A61F2002/0858 , A61F2002/4435
摘要： The staple legs with tissue gripping elements are elastically curved. Curvatures of the legs are resiliently straightened and spearheaded by a pair of trocars for puncturing into tissue. While the staple is held stationary by a sleeve, the trocars are withdrawn to allow the legs to resume curvatures, elastically fastening the tissue.
摘要翻译： 具有组织夹紧元件的钉腿弹性弯曲。 腿的弯曲部被弹性地拉直，并被一对针刺刺穿到组织中的套针头引导。 当钉子被套筒固定时，套管针被拉出以允许腿部恢复曲率，弹性地紧固组织。
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公开(公告)号：US10561503B2
公开(公告)日：2020-02-18
申请号：US15932542
申请日：2018-03-12
申请人： Jeffrey E. Yeung , Teresa T. Yeung
发明人： Jeffrey E. Yeung , Teresa T. Yeung
摘要： Disc degeneration and chronic back pain are caused by a transport hindrance of oxygen, nutrients and pH buffer from capillaries in endplates into mid-layer of the intervertebral disc. A fluid absorbing conduit is inserted into the intervertebral disc, drawing and delivering the oxygen, nutrients and pH buffer in fluid of body circulation from capillaries at endplates into the mid-layer of the disc. The disc undergoes thousands of relaxation and compression cycles each day from daily activity of the patient. During relaxation phase, the fluid of body circulation containing oxygen, nutrients, and pH buffer is infused into the fluid absorbing conduit. During compression phase, the oxygen, nutrients, and pH buffer in the fluid absorbing conduit is dispersed into the mid-layer of the disc. The pH buffer, bicarbonate, neutralizes the lactic acid to relieve the discogenic pain. Oxygen inhibits hypoxic inflammation and production of lactic acid to further reduce the discogenic pain. Nutrients nourish the disc cells to rebuild or regenerate the disc matrix.Therapeutic agents can be added into the fluid absorbing conduit or injected into the disc implanted with the fluid absorbing conduit to expedite pain relief and disc regeneration. The therapeutic agents can be pH buffering agent, antibiotic, anti-inflammatory drug, anesthetic, antacid, nutrient, sulfate, anti-depressant, calcium channel blocker, growth factor, cells or other.
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公开(公告)号：US20180207004A1
公开(公告)日：2018-07-26
申请号：US15932542
申请日：2018-03-12
申请人： Jeffrey E. Yeung , Teresa T. Yeung
发明人： Jeffrey E. Yeung , Teresa T. Yeung
摘要： Disc degeneration and chronic back pain are caused by a transport hindrance of oxygen, nutrients and pH buffer from capillaries in endplates into mid-layer of the intervertebral disc. A fluid absorbing conduit is inserted into the intervertebral disc, drawing and delivering the oxygen, nutrients and pH buffer in fluid of body circulation from capillaries at endplates into the mid-layer of the disc. The disc undergoes thousands of relaxation and compression cycles each day from daily activity of the patient. During relaxation phase, the fluid of body circulation containing oxygen, nutrients, and pH buffer is infused into the fluid absorbing conduit. During compression phase, the oxygen, nutrients, and pH buffer in the fluid absorbing conduit is dispersed into the mid-layer of the disc. The pH buffer, bicarbonate, neutralizes the lactic acid to relieve the discogenic pain. Oxygen inhibits hypoxic inflammation and production of lactic acid to further reduce the discogenic pain. Nutrients nourish the disc cells to rebuild or regenerate the disc matrix.Therapeutic agents can be added into the fluid absorbing conduit or injected into the disc implanted with the fluid absorbing conduit to expedite pain relief and disc regeneration. The therapeutic agents can be pH buffering agent, antibiotic, anti-inflammatory drug, anesthetic, antacid, nutrient, sulfate, anti-depressant, calcium channel blocker, growth factor, cells or other.
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公开(公告)号：US20160058566A1
公开(公告)日：2016-03-03
申请号：US14756016
申请日：2015-07-21
申请人： Jeffrey E. Yeung , Teresa T. Yeung
发明人： Jeffrey E. Yeung , Teresa T. Yeung
CPC分类号： A61F2/442 , A61B17/0483 , A61B17/3468 , A61B17/7061 , A61B17/7094 , A61B17/8852 , A61B2017/00805 , A61B2017/00867 , A61F2/0036 , A61F2/4611 , A61F2002/30289 , A61F2002/30294 , A61F2002/30677 , A61F2002/444 , A61F2002/4495 , A61F2002/4635 , A61F2210/0061 , A61F2230/0091 , A61F2250/0067 , A61F2310/00598 , A61F2310/0061 , A61F2310/0097 , A61F2310/00976 , A61F2310/00982
摘要： A distal portion of a filament is extended beyond the distal end of a needle with a gripper. The needle with the extended filament is inserted into a cannula with snagging points at the distal opening of the cannula in tissue. The snagging points of the cannula hook and retain the distal portion of the filament. During partial withdrawal of the needle, a section of filament is deposited in the lumen of the cannula between the distal ends of the needle and cannula. When the needle is re-advanced, the section of filament is expelled or pushed out of the cannula into tissue. The needle is then rotated; the gripper engages and spirals the expelled filament, burrowing into tissue. The needle can further advanced to push and pack the spiral of filament deep into the tissue. The knot-like filament spiral is individually formed by rotation of the needle and friction between the extended filament and tissue. The process of needle partial withdrawal, re-advancement, rotation and pushing is repeated to pack and fill the tissue with interconnecting spirals of filament to prevent migration from tissue. Spiraling of the filament driven by the rotating needle is space seeking, filling, fitting or conforming to fortify, bulk, fill, cushion or repair the tissue. Bulking with filament spirals can repair degenerated disc, urinary incontinence, fecal incontinence or other defective tissue. The filament spirals can also be used as a suture anchor deep within tissue.
摘要翻译： 长丝的远端部分用夹具延伸超过针的远端。 将具有延伸细丝的针插入具有在组织中插管的远端开口处的阻塞点的插管中。 插管钩的阻塞点并保持丝的远端部分。 在针的部分抽出期间，在针和插管的远端之间的一段细丝沉积在套管的内腔中。 当针被重新推进时，细丝的部分被排出或从套管推出到组织中。 然后将针旋转; 夹具接合并螺旋排出的细丝，挖入组织。 针可以进一步推进以将丝的螺旋深入推入并包装到组织中。 结状丝状螺旋通过针的旋转和延长的丝和组织之间的摩擦分别形成。 针头部分抽出，再推进，旋转和推动的过程重复，用纤维互连的螺旋填充和填充组织以防止从组织迁移。 由旋转针驱动的丝的螺旋形是空间寻找，填充，配合或符合以强化，散装，填充，缓冲或修复组织。 用丝状螺旋填充可以修复退化的椎间盘，尿失禁，大便失禁或其他有缺陷的组织。 长丝螺旋也可以用作组织内深层的缝合锚。
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公开(公告)号：US20100198274A1
公开(公告)日：2010-08-05
申请号：US12798773
申请日：2010-04-10
IPC分类号： A61B17/56
CPC分类号： A61B17/70 , A61B2017/00004 , A61B2017/00867 , A61F2002/4435
摘要： With limited nutrients within the avascular disc, the water-retaining proteoglycans begin to diminish, resulting in dehydration, flattening and/or bulging of the disc. The flattened disc causes segmental instability, eroding the facet joints and causing pain.In this invention, a disc inserting device contains a horizontally oriented protrusion with superior and inferior plateaus for inserting into the degenerated disc to maintain or restore disc height. The horizontally oriented protrusion is adjoined to a vertically oriented concave bracket with screw holes for fastening the concave bracket to the vertebral bodies sandwiching the degenerated disc. Thereby, the disc height is restored and fortified to reduce segmental instability and erosion of facet joints for pain relief. Furthermore, by altering the slopes of the plateaus, thickness and depth of the protrusion, spinal stenosis, scoliosis, kyphosis, lordosis or spondylolisthesis can be corrected with the disc inserting device.
摘要翻译： 在无血管盘内有营养成分，保水蛋白聚糖开始减弱，导致椎间盘脱水，扁平化和/或隆起。 扁平盘导致节段不稳定，侵蚀小关节并引起疼痛。 在本发明中，盘插入装置包括一个具有上下平台的水平方向的突起，用于插入退化的盘中以维持或恢复盘的高度。 水平定向的突起与垂直定向的凹形支架相邻，其具有用于将凹形支架固定到夹着退化盘的椎体的螺钉孔。 因此，恢复并强化椎间盘高度以减少小面关节的节段性不稳定性和疼痛缓解的侵蚀。 此外，通过改变高原的斜坡，突起的厚度和深度，可以用盘插入装置来校正脊柱狭窄，脊柱侧弯，脊柱后凸，脊柱前凸或脊椎前移。
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公开(公告)号：US07766939B2
公开(公告)日：2010-08-03
申请号：US10914059
申请日：2004-08-05
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0467 , A61B2017/00805 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0437 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61B2090/062
摘要： An elastically curved suture anchor is resiliently straightened and delivered into tissue by a needle. When the needle is withdrawn, resumption of the curvature provides leverage for anchor rotation as the attached suture is pulled to fasten the anchor within the tissue. A fin at the proximal end of the anchor further increases the rotational leverage and expedites anchor fastening. When two or more anchors with connecting suture are delivered in series on a needle, the tension of the suture helps to draw the anchors together and approximates the pierced tissue.
摘要翻译： 弹性弯曲的缝合锚固件被弹性地拉直并通过针递送到组织中。 当针被取出时，恢复曲率提供锚定旋转的杠杆作用，因为所附连接的缝合线被拉紧以将锚固件固定在组织内。 在锚的近端处的翅片进一步增加旋转杠杆并加快锚固。 当具有连接缝合线的两个或多个锚固件被串联地递送到针上时，缝合线的张力有助于将锚固件拉到一起并且近似穿刺的组织。
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