公开(公告)号：US20120302496A1

公开(公告)日：2012-11-29

申请号：US13514538

申请日：2010-12-07

申请人： Achim Harder ,  Klemens Krieger ,  Thi Lam Huong Pham ,  Thanh Dam Huynh ,  Irmtraut Zaspel ,  Dietrich Ewald ,  Clemens Mügge ,  Hardy Weisshoff

发明人： Achim Harder ,  Klemens Krieger ,  Thi Lam Huong Pham ,  Thanh Dam Huynh ,  Irmtraut Zaspel ,  Dietrich Ewald ,  Clemens Mügge ,  Hardy Weisshoff

IPC分类号： C07K11/02 ,  A61P33/10 ,  A61P33/00 ,  C12P21/04 ,  A61K38/15

CPC分类号： C07D273/00

摘要： The present invention relates firstly to the discovery of the previously unknown 24-membered cyclooctadepsipeptides PF1022-V, PF1022-W, XRB-C894, XRB-C942, XRB-C976, XRB-C1010, XRB-C1044, XRB-E922, XRB-E956, XRB-E990, XRB-E1024, XRB-S958, XRB-S992, XRB-S1026, XRB-S1060 (in various isomeric forms) and to the processes for the preparation of the abovementioned cyclooctadepsipeptides by means of the fungal strains from the family Xylariaceae, in particular the genera Rosellinia and Coniolariella, and by means of the mitosporic fungal strains from the groups Fusarium, Beauveria and Verticillium (orders Hypocreales and Phyllachorales), and by means of the enzymatic preparations isolated from these fungal strains, and secondly to the use of these strains for the preparation of the abovementioned novel cyclooctadepsipeptides and to the use of bassianolide and of the abovementioned novel cyclooctadepsipeptides individually or as a mixture, as anthelmintics or endoparasiticides.

摘要翻译： 本发明首先涉及以前未知的24-元环十二肽肽PF1022-V，PF1022-W，XRB-C894，XRB-C942，XRB-C976，XRB-C1010，XRB-C1044，XRB-E922，XRB- E956，XRB-E990，XRB-E1024，XRB-S958，XRB-S992，XRB-S1026，XRB-S1060（各种异构形式）以及上述环庚三烯肽的制备方法， 以及通过来自镰刀菌，白僵菌和轮枝孢属（命名为Hypocreales和Phyllachorales）的分枝杆菌真菌菌株，并通过从这些真菌菌株分离的酶制剂，以及其次为 使用这些菌株制备上述新型的环庚三烯肽，以及使用巴西酰胺和上述新型的环辛酸肽单独或作为混合物作为驱肠虫剂或内寄生虫杀菌剂。