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    NOVEL 24-MEMBERED CYCLOOCTADEPSIPEPTIDES FROM FUNGAL STRAINS AND THEIR USE AS ANTHELMINTICS OR ENDOPARASITICIDES
    1.
    发明申请
    NOVEL 24-MEMBERED CYCLOOCTADEPSIPEPTIDES FROM FUNGAL STRAINS AND THEIR USE AS ANTHELMINTICS OR ENDOPARASITICIDES 审中-公开
    来自真菌菌株的新型24位CYCLOOCTADEPSIPEPTISES及其作为安非他明或内给药的用途

    公开(公告)号：US20120302496A1

    公开(公告)日：2012-11-29

    申请号：US13514538

    申请日：2010-12-07

    申请人： Achim Harder ,  Klemens Krieger ,  Thi Lam Huong Pham ,  Thanh Dam Huynh ,  Irmtraut Zaspel ,  Dietrich Ewald ,  Clemens Mügge ,  Hardy Weisshoff

    发明人： Achim Harder ,  Klemens Krieger ,  Thi Lam Huong Pham ,  Thanh Dam Huynh ,  Irmtraut Zaspel ,  Dietrich Ewald ,  Clemens Mügge ,  Hardy Weisshoff

    IPC分类号： C07K11/02 ,  A61P33/10 ,  A61P33/00 ,  C12P21/04 ,  A61K38/15

    CPC分类号： C07D273/00

    摘要： The present invention relates firstly to the discovery of the previously unknown 24-membered cyclooctadepsipeptides PF1022-V, PF1022-W, XRB-C894, XRB-C942, XRB-C976, XRB-C1010, XRB-C1044, XRB-E922, XRB-E956, XRB-E990, XRB-E1024, XRB-S958, XRB-S992, XRB-S1026, XRB-S1060 (in various isomeric forms) and to the processes for the preparation of the abovementioned cyclooctadepsipeptides by means of the fungal strains from the family Xylariaceae, in particular the genera Rosellinia and Coniolariella, and by means of the mitosporic fungal strains from the groups Fusarium, Beauveria and Verticillium (orders Hypocreales and Phyllachorales), and by means of the enzymatic preparations isolated from these fungal strains, and secondly to the use of these strains for the preparation of the abovementioned novel cyclooctadepsipeptides and to the use of bassianolide and of the abovementioned novel cyclooctadepsipeptides individually or as a mixture, as anthelmintics or endoparasiticides.

    摘要翻译： 本发明首先涉及以前未知的24-元环十二肽肽PF1022-V，PF1022-W，XRB-C894，XRB-C942，XRB-C976，XRB-C1010，XRB-C1044，XRB-E922，XRB- E956，XRB-E990，XRB-E1024，XRB-S958，XRB-S992，XRB-S1026，XRB-S1060（各种异构形式）以及上述环庚三烯肽的制备方法， 以及通过来自镰刀菌，白僵菌和轮枝孢属（命名为Hypocreales和Phyllachorales）的分枝杆菌真菌菌株，并通过从这些真菌菌株分离的酶制剂，以及其次为 使用这些菌株制备上述新型的环庚三烯肽，以及使用巴西酰胺和上述新型的环辛酸肽单独或作为混合物作为驱肠虫剂或内寄生虫杀菌剂。

    METHOD FOR PRODUCING OPTICALLY ACTIVE, CYCLIC DEPSIPEPTIDES COMPRISING LACTIC ACID AND PHENYL LACTIC AND HAVING 24 RING ATOMS, USING FUNGUS STRAINS OF ROSELLINIA TYPE, AND FURTHER SPECIES OF XYLARIACEAE
    2.
    发明申请
    METHOD FOR PRODUCING OPTICALLY ACTIVE, CYCLIC DEPSIPEPTIDES COMPRISING LACTIC ACID AND PHENYL LACTIC AND HAVING 24 RING ATOMS, USING FUNGUS STRAINS OF ROSELLINIA TYPE, AND FURTHER SPECIES OF XYLARIACEAE 审中-公开
    用于生产含有乳酸和苯乙酸并具有24环状物的光学活性循环阻断剂的方法，其使用罗氏霉素类型的真菌菌株，以及其他物种的XYLARIACEAE

    公开(公告)号：US20110262969A1

    公开(公告)日：2011-10-27

    申请号：US13133611

    申请日：2009-12-08

    申请人： Achim Harder ,  Thi Lam Huong Pham ,  Rene Jarling ,  Irmtraut Zaspel ,  Dietrich Ewald

    发明人： Achim Harder ,  Thi Lam Huong Pham ,  Rene Jarling ,  Irmtraut Zaspel ,  Dietrich Ewald

    IPC分类号： C12P21/04 ,  C12P13/04

    CPC分类号： C12P17/14

    摘要： The present invention relates to a process for the preparation of lactic- and phenyllactic-acid-containing, optically active, cyclic depsipeptides with 24 ring atoms by means of fungal strains of the genus Rosellinia and further Xylariaceae isolated not only from fruiting bodies of Rosellinia spp. and Xylariaceae growing on dead timber and live timber of deciduous and coniferous trees, but also directly from timber and roots of deciduous and coniferous trees, or by means of enzymatic preparations isolated from these fungal strains. PF1022A, of the general formula (I), is outstandingly suitable for controlling endoparasites, in particular in the field of medicine and veterinary medicine.

    摘要翻译： 本发明涉及一种通过Rosellinia属的真菌菌株制备具有24个环原子的含乳酸和苯基乳酸的光学活性的环状缩缩肽的方法，并且其进一步分离了不仅从Rosellinia spp的子实体中分离得到的木聚糖酶 。 和木犀科生长在落叶和针叶树的死木和活木上，也直接来自落叶和针叶树的木材和根，或通过从这些真菌菌株分离的酶制剂。 通式（I）的PF1022A非常适用于控制内寄生虫，特别是在医药兽药领域。