公开(公告)号：US20120302496A1

公开(公告)日：2012-11-29

申请号：US13514538

申请日：2010-12-07

申请人： Achim Harder ,  Klemens Krieger ,  Thi Lam Huong Pham ,  Thanh Dam Huynh ,  Irmtraut Zaspel ,  Dietrich Ewald ,  Clemens Mügge ,  Hardy Weisshoff

发明人： Achim Harder ,  Klemens Krieger ,  Thi Lam Huong Pham ,  Thanh Dam Huynh ,  Irmtraut Zaspel ,  Dietrich Ewald ,  Clemens Mügge ,  Hardy Weisshoff

IPC分类号： C07K11/02 ,  A61P33/10 ,  A61P33/00 ,  C12P21/04 ,  A61K38/15

CPC分类号： C07D273/00

摘要： The present invention relates firstly to the discovery of the previously unknown 24-membered cyclooctadepsipeptides PF1022-V, PF1022-W, XRB-C894, XRB-C942, XRB-C976, XRB-C1010, XRB-C1044, XRB-E922, XRB-E956, XRB-E990, XRB-E1024, XRB-S958, XRB-S992, XRB-S1026, XRB-S1060 (in various isomeric forms) and to the processes for the preparation of the abovementioned cyclooctadepsipeptides by means of the fungal strains from the family Xylariaceae, in particular the genera Rosellinia and Coniolariella, and by means of the mitosporic fungal strains from the groups Fusarium, Beauveria and Verticillium (orders Hypocreales and Phyllachorales), and by means of the enzymatic preparations isolated from these fungal strains, and secondly to the use of these strains for the preparation of the abovementioned novel cyclooctadepsipeptides and to the use of bassianolide and of the abovementioned novel cyclooctadepsipeptides individually or as a mixture, as anthelmintics or endoparasiticides.

摘要翻译： 本发明首先涉及以前未知的24-元环十二肽肽PF1022-V，PF1022-W，XRB-C894，XRB-C942，XRB-C976，XRB-C1010，XRB-C1044，XRB-E922，XRB- E956，XRB-E990，XRB-E1024，XRB-S958，XRB-S992，XRB-S1026，XRB-S1060（各种异构形式）以及上述环庚三烯肽的制备方法， 以及通过来自镰刀菌，白僵菌和轮枝孢属（命名为Hypocreales和Phyllachorales）的分枝杆菌真菌菌株，并通过从这些真菌菌株分离的酶制剂，以及其次为 使用这些菌株制备上述新型的环庚三烯肽，以及使用巴西酰胺和上述新型的环辛酸肽单独或作为混合物作为驱肠虫剂或内寄生虫杀菌剂。

公开(公告)号：US06830932B1

公开(公告)日：2004-12-14

申请号：US09762691

申请日：2001-02-09

申请人： Oliver Danne ,  Ulrich Frei ,  Adolf Zschunke ,  Clemens Mügge

发明人： Oliver Danne ,  Ulrich Frei ,  Adolf Zschunke ,  Clemens Mügge

IPC分类号： G01N3300

CPC分类号： G01N33/92 ,  Y10S436/811

摘要： The invention relates to an in vitro method of recognizing acute coronary syndroms, especially an acute myocardial infarction, by determining and evaluating the content of choline, choline and/or trimethyl ammonium derivatives selected from the group comprising phosphoryl choline, plasmalogens, and lysoplasmenyl choline, and/or the reaction products thereof selected from the group comprising 1-O-alk-1′-enyl-2 substituted glycerol and 1-O-alk-1′-enyl-2 substituted glycerol phosphate in body fluids or component parts of the body, said method comprising the following steps: drawing a sample of a suitable body fluid or component part of the body; determining the content of choline, choline and/or trimethyl ammonium derivatives selected from the group comprising phosphoryl choline, plasmalogens, and lysoplasmenyl choline, and/or the reaction products thereof selected from the group comprising 1-O-alk-1′-enyl-2 substituted glycerol and 1-O-alk-1′-enyl-2 substituted glycerol phosphate by a suitable method of determination (nuclear magnetic resonance methods, biochemical, enzymatic, immunological, clinical-chemical, chromatographic, mass spectrometric, electrochemical, photometric methods, or other methods); and evaluating the measured results, taking into account a limit value for recognition or exclusion of acute coronary syndroms, especially an acute myocardial infarction.

摘要翻译： 本发明涉及通过确定和评估选自磷酸胆碱，血浆原和溶血素胆碱的胆碱，胆碱和/或三甲基铵衍生物的含量来鉴定急性冠状动脉综合征，特别是急性心肌梗塞的体外方法， 和/或其选自包含1-O-烷基-1'-烯基-2取代的甘油和1-O-烷基-1'-烯基-2取代的甘油磷酸酯的反应产物在体液或组分部分 所述方法包括以下步骤：绘制身体的合适体液或组分部分的样品; 确定选自磷酸胆碱，血浆原和血清素胆碱的胆碱，胆碱和/或三甲基铵衍生物的含量，和/或其选自包含1-O-烷基-1'-烯基 - 2取代甘油和1-O-烷基-1'-烯基-2取代的甘油磷酸酯通过合适的测定方法（核磁共振法，生物化学，酶学，免疫学，临床化学，色谱，质谱，电化学，光度法 ，或其他方法）; 并评估测量结果，同时考虑到识别或排除急性冠状动脉综合征，特别是急性心肌梗死的极限值。