公开(公告)号：US08133971B2

公开(公告)日：2012-03-13

申请号：US12391857

申请日：2009-02-24

申请人： Byung-Heon Lee ,  In-San Kim ,  Thapa Narendra

发明人： Byung-Heon Lee ,  In-San Kim ,  Thapa Narendra

IPC分类号： C07K5/10

CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

摘要翻译： 本发明涉及与磷脂酰丝氨酸特异性结合的多肽及其用途，更具体地说涉及具有指定为序列号1并特异性结合磷脂酰丝氨酸的氨基酸序列的多肽，含有多肽作为活性成分的磷脂酰丝氨酸检测组合物， 通过使用多肽检测磷脂酰丝氨酸的方法，包含多肽作为活性成分的凋亡细胞检测，含有多肽作为活性成分的药物递送组合物，用于治疗和预防肿瘤性疾病的组合物，以及用于可视化的组合物 肿瘤区。 具有指定为序列号1的氨基酸序列的多肽与磷脂酰丝氨酸具体结合。 因此，本发明的多肽可用于检测磷脂酰丝氨酸，此外还检测在细胞和肿瘤细胞表面上表达磷脂酰丝氨酸的凋亡细胞，并且还可用于凋亡细胞或肿瘤细胞的可视化。

公开(公告)号：US20090214430A1

公开(公告)日：2009-08-27

申请号：US12391857

申请日：2009-02-24

申请人： Byung-Heon LEE ,  In-San KIM ,  Thapa NARENDRA

发明人： Byung-Heon LEE ,  In-San KIM ,  Thapa NARENDRA

IPC分类号： A61K49/00 ,  C07K7/06 ,  C07H21/04 ,  C12N15/63 ,  C12N9/00 ,  G01N33/53 ,  A61K38/08

CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

摘要翻译： 本发明涉及与磷脂酰丝氨酸特异性结合的多肽及其用途，更具体地说涉及具有指定为序列号1并特异性结合磷脂酰丝氨酸的氨基酸序列的多肽，含有多肽作为活性成分的磷脂酰丝氨酸检测组合物， 通过使用多肽检测磷脂酰丝氨酸的方法，包含多肽作为活性成分的凋亡细胞检测，含有多肽作为活性成分的药物递送组合物，用于治疗和预防肿瘤性疾病的组合物，以及用于可视化的组合物 肿瘤区。 具有指定为序列号1的氨基酸序列的多肽与磷脂酰丝氨酸具体结合。 因此，本发明的多肽可用于检测磷脂酰丝氨酸，此外还检测在细胞和肿瘤细胞表面上表达磷脂酰丝氨酸的凋亡细胞，并且还可用于凋亡细胞或肿瘤细胞的可视化。