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公开(公告)号：US08993721B2
公开(公告)日：2015-03-31
申请号：US13467689
申请日：2012-05-09
申请人： Byung Heon Lee , In San Kim
发明人： Byung Heon Lee , In San Kim
CPC分类号： A61K47/48246 , A61K38/00 , A61K47/64 , A61K49/0032 , A61K49/0043 , A61K49/0056 , C07K7/06 , C07K2319/33 , G01N2510/00
摘要： Described herein is an isolated polypeptide which is capable of specifically targeting apoptotic cells undergoing apoptosis and consists of the sequence (I): Cys-X1-Val-Ala-Pro-X2 (I), wherein X1 is an amino acid with polar uncharged side chain and X2 is an amino acid with positive charged side chain. The isolated polypeptide of the present invention may be useful for detecting apoptotic cells, as well as detecting and imaging apoptotic cells in tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in stroke tissue, and arteriosclerosis site; the polypeptide is useful for targeted drug delivery thereto.
摘要翻译： 本文描述了能够特异性靶向经历凋亡的凋亡细胞并由序列（I）：Cys-X1-Val-Ala-Pro-X2（I）组成的分离的多肽，其中X1是具有极性不带电侧的氨基酸 链和X2是具有正带侧链的氨基酸。 本发明的分离的多肽可用于检测凋亡细胞，以及检测和成像肿瘤组织中的凋亡细胞，心肌梗死组织中的凋亡心肌细胞，卒中组织中的凋亡性神经细胞和动脉硬化部位; 该多肽可用于靶向药物递送。
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2.发明申请TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF 有权用于诊断和治疗含有特异性靶向白细胞介素-4受体的肽的含有脂蛋白的癌症靶向药物递送系统及其制造方法公开(公告)号：US20120294931A1
公开(公告)日：2012-11-22
申请号：US13519821
申请日：2010-12-29
申请人： In San Kim , Byung Heon Lee , Maggie JM Lu , Hsiang-Fa Liang , Yi-ju Ko , Ya-Chin Lo , Li-Wen Chang , Ming-Cheng Wei
发明人： In San Kim , Byung Heon Lee , Maggie JM Lu , Hsiang-Fa Liang , Yi-ju Ko , Ya-Chin Lo , Li-Wen Chang , Ming-Cheng Wei
IPC分类号： A61K9/127 , A61P35/00 , A61K31/704
CPC分类号： A61K31/704 , A61K9/1271 , A61K38/00 , A61K47/6911
摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.
摘要翻译： 本发明涉及用于诊断和治疗特异性靶向白介素-4受体的肽标记的含有脂质体的癌症靶向药物递送系统及其制造方法。 含有根据本发明制备的用IL4RPep肽标记的抗癌药物的脂质体可将药物递送至IL-4受体被特异性结合IL-4受体的IL4Rep肽过表达的癌细胞，并且药物递送可以识别癌症 细胞特异性地通过标记。 因此，IL4RPep肽可以增加药物对癌症组织的影响，同时显着降低对正常组织的副作用，这使得体内（分子）成像和肿瘤早期诊断成为可能。 因此，含有本发明的IL4Pep肽标记的抗癌药物的脂质体可以作为靶向药物递送系统有效地应用于癌症的诊断和治疗。
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3.发明授权Peptide for diagnosing, preventing and treating atherosclerosis and uses thereof 有权用于诊断，预防和治疗动脉粥样硬化的肽及其用途公开(公告)号：US07968081B2
公开(公告)日：2011-06-28
申请号：US12009359
申请日：2008-01-18
申请人： Byung Heon Lee , In San Kim , Hai Yan Hong , In Seop So
发明人： Byung Heon Lee , In San Kim , Hai Yan Hong , In Seop So
CPC分类号： G01N33/6893 , C07K7/06 , G01N2800/323
摘要： A peptide for diagnosing, preventing and treating atherosclerosis, and a use thereof, comprising an amino acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2, and a use thereof. The peptide effectively targets atherosclerotic plaques, and binds to IL-4R to thereby exhibit antagonistic effects on IL-4-mediated signaling of cellular inflammatory reaction and survival reaction. The peptide of the present invention can be used for diagnosis of atherosclerosis, prevention and treatment of IL-4-induced inflammatory reaction and prevention and treatment of atherosclerosis which is primarily caused by the inflammatory reaction, as well as for prevention or treatment of atherosclerosis via conjugation with an anti-atherosclerotic drug.
摘要翻译： 用于诊断，预防和治疗动脉粥样硬化的肽及其用途，其包含SEQ ID NO：1或SEQ ID NO：2所示的氨基酸序列及其用途。 该肽有效靶向动脉粥样硬化斑块，并结合IL-4R，从而对IL-4介导的细胞炎症反应和存活反应的信号传导具有拮抗作用。 本发明的肽可用于诊断动脉粥样硬化，预防和治疗IL-4诱导的炎性反应以及主要由炎性反应引起的动脉粥样硬化的预防和治疗，以及预防或治疗动脉粥样硬化通过 与抗动脉粥样硬化药物结合。
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公开(公告)号：US20120316101A1
公开(公告)日：2012-12-13
申请号：US13467689
申请日：2012-05-09
申请人： Byung Heon Lee , In San Kim
发明人： Byung Heon Lee , In San Kim
IPC分类号： C07K7/06 , A61K38/08 , A61P35/00 , A61P9/10 , A61P35/02 , G01N27/72 , C12N1/21 , C12N9/96 , G01N21/64 , G01N21/78 , G01N21/25 , C12N15/11 , A61P25/00
CPC分类号： A61K47/48246 , A61K38/00 , A61K47/64 , A61K49/0032 , A61K49/0043 , A61K49/0056 , C07K7/06 , C07K2319/33 , G01N2510/00
摘要： The present invention relates to a polypeptide capable of specifically targeting apoptotic cells undergoing apoptosis and a use thereof. More particularly, it relates to an isolated polypeptide consisting of the sequence (I): Cys-X1-Val-Ala-Pro-X2 (I), wherein X1 is an amino acid with polar uncharged side chain and X2 is an amino acid with positive charged side chain and targeting apoptotic cells, a composition for detection of apoptotic cells comprising the same as an effective ingredient, a composition for drug delivery comprising the same as an effective ingredient, a composition for imaging comprising the same as an effective ingredient and the like. Accordingly, the peptide of the present invention may be useful for detection of apoptotic cells, as well as detection and imaging of apoptotic cells in tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in stroke tissue and arteriosclerosis site, and targeted drug delivery thereto.
摘要翻译： 本发明涉及能够特异性靶向经历凋亡的凋亡细胞的多肽及其用途。 更具体地，涉及由序列（I）：Cys-X1-Val-Ala-Pro-X2（I）组成的分离的多肽，其中X1是具有极性不带电侧链的氨基酸，X2是具有 阳性带电侧链和靶向凋亡细胞，用于检测包含其作为有效成分的凋亡细胞的组合物，用于药物递送的组合物，其包含作为有效成分的组合物，用于成像的组合物，其包含作为有效成分的组合物和 喜欢。 因此，本发明的肽可用于检测凋亡细胞，以及肿瘤组织中凋亡细胞，心肌梗死组织中的凋亡性心肌细胞，卒中组织和动脉硬化部位的凋亡性神经细胞的检测和成像以及靶向 给药药物。
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5.发明申请PEPTIDE WHICH PASSES THROUGH BLOOD-BRAIN BARRIER AND TARGETS APOPTOSIS OF NEURODEGENERATIVE BRAIN DISEASE SITE AND USES THEREOF 有权通过血脑屏障通过的肽和靶向神经损伤性脑病的病原体及其用途公开(公告)号：US20120288447A1
公开(公告)日：2012-11-15
申请号：US13469729
申请日：2012-05-11
申请人： Byung-Heon Lee , In San Kim , Jae-Sung Bae , Hee Kyoung Jin , Hyung Soo Han
发明人： Byung-Heon Lee , In San Kim , Jae-Sung Bae , Hee Kyoung Jin , Hyung Soo Han
CPC分类号： A61K49/0002 , A61K38/00 , A61K47/64 , A61K49/0032 , A61K49/0056 , B82Y5/00 , C07K7/06
摘要： The present invention relates to a peptide that passes through a blood-brain barrier and targets apoptosis of neurodegenerative brain disease-affected sites and uses thereof. More particularly, the present invention relates to a composition for delivering drugs to brain tissues, a composition for detecting apoptotic cells of neurodegenerative brain disease-affected sites, and a composition for imaging the neurodegenerative brain disease-affected sites which comprises a peptide having an amino acid sequence represented by SEQ ID: No. 1 respectively, and a composition for prevention, treatment, or theranosis of neurodegenerative brain diseases comprising said peptide. The peptide of the present invention can be used for detecting apoptosis in neurodegenerative brain diseases and further detecting apoptotic cells (especially apoptotic neuronal cells) in neurodegenerative brain disease-affected sites and imaging, targeted drug delivery, theranosis.
摘要翻译： 本发明涉及穿过血脑屏障并靶向神经退行性脑损伤部位的细胞凋亡的肽及其用途。 更具体地，本发明涉及用于将药物递送至脑组织的组合物，用于检测神经变性脑病变部位的凋亡细胞的组合物，以及用于对神经变性性脑病变影响部位进行成像的组合物，所述组合物包含具有氨基 分别由SEQ ID：No.1表示的酸序列，以及包含所述肽的神经变性性脑病的预防，治疗或异常的组合物。 本发明的肽可用于检测神经变性脑疾病的凋亡，并进一步检测神经变性脑疾病影响部位的凋亡细胞（特别是凋亡性神经元细胞），成像，靶向药物递送，神经病变。
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公开(公告)号：US08217012B2
公开(公告)日：2012-07-10
申请号：US12465007
申请日：2009-05-13
申请人： Byung Heon Lee , In San Kim
发明人： Byung Heon Lee , In San Kim
CPC分类号： C07K7/06 , A61K38/00 , A61K47/64 , A61K49/0032 , A61K49/0043 , A61K49/0056 , C07K2319/33 , G01N2510/00
摘要： A peptide capable of specifically targeting apoptotic cells undergoing apoptosis and a use thereof is described. Peptides having an amino acid sequence represented by any one of SEQ ID NO: 1 to SEQ ID NO: 12 targeted apoptotic cell. Uses for compositions comprising the peptides include detection of apoptotic cells drug delivery and imaging. The peptide of the present invention effectively detects apoptosis which is involved in tissues of neoplastic disease, myocardial infarction, stroke and arteriosclerosis. Accordingly, the peptide of the present invention may be bound to an imaging or treatment reagent to be used in diagnosis of diseases, imaging of drug reactions, and treatment for diseases by selective drug delivery.
摘要翻译： 描述了能够特异性靶向经历凋亡的凋亡细胞的肽及其用途。 具有由SEQ ID NO：1至SEQ ID NO：12中任一个表示的氨基酸序列的肽靶向凋亡细胞。 包含肽的组合物的用途包括检测凋亡细胞药物递送和成像。 本发明的肽有效地检测参与肿瘤性疾病，心肌梗死，中风和动脉硬化的组织的凋亡。 因此，本发明的肽可以与用于诊断疾病，药物反应成像和通过选择性药物递送治疗疾病的成像或治疗试剂结合。
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7.发明授权公开(公告)号：US08133971B2
公开(公告)日：2012-03-13
申请号：US12391857
申请日：2009-02-24
申请人： Byung-Heon Lee , In-San Kim , Thapa Narendra
发明人： Byung-Heon Lee , In-San Kim , Thapa Narendra
IPC分类号： C07K5/10
CPC分类号： G01N33/57492 , A61K47/64 , A61K49/0043 , C07K7/06 , G01N33/92 , G01N2405/04 , G01N2510/00 , Y02A50/58
摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.
摘要翻译： 本发明涉及与磷脂酰丝氨酸特异性结合的多肽及其用途，更具体地说涉及具有指定为序列号1并特异性结合磷脂酰丝氨酸的氨基酸序列的多肽，含有多肽作为活性成分的磷脂酰丝氨酸检测组合物， 通过使用多肽检测磷脂酰丝氨酸的方法，包含多肽作为活性成分的凋亡细胞检测，含有多肽作为活性成分的药物递送组合物，用于治疗和预防肿瘤性疾病的组合物，以及用于可视化的组合物 肿瘤区。 具有指定为序列号1的氨基酸序列的多肽与磷脂酰丝氨酸具体结合。 因此，本发明的多肽可用于检测磷脂酰丝氨酸，此外还检测在细胞和肿瘤细胞表面上表达磷脂酰丝氨酸的凋亡细胞，并且还可用于凋亡细胞或肿瘤细胞的可视化。
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8.发明申请公开(公告)号：US20090214430A1
公开(公告)日：2009-08-27
申请号：US12391857
申请日：2009-02-24
申请人： Byung-Heon LEE , In-San KIM , Thapa NARENDRA
发明人： Byung-Heon LEE , In-San KIM , Thapa NARENDRA
CPC分类号： G01N33/57492 , A61K47/64 , A61K49/0043 , C07K7/06 , G01N33/92 , G01N2405/04 , G01N2510/00 , Y02A50/58
摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.
摘要翻译： 本发明涉及与磷脂酰丝氨酸特异性结合的多肽及其用途，更具体地说涉及具有指定为序列号1并特异性结合磷脂酰丝氨酸的氨基酸序列的多肽，含有多肽作为活性成分的磷脂酰丝氨酸检测组合物， 通过使用多肽检测磷脂酰丝氨酸的方法，包含多肽作为活性成分的凋亡细胞检测，含有多肽作为活性成分的药物递送组合物，用于治疗和预防肿瘤性疾病的组合物，以及用于可视化的组合物 肿瘤区。 具有指定为序列号1的氨基酸序列的多肽与磷脂酰丝氨酸具体结合。 因此，本发明的多肽可用于检测磷脂酰丝氨酸，此外还检测在细胞和肿瘤细胞表面上表达磷脂酰丝氨酸的凋亡细胞，并且还可用于凋亡细胞或肿瘤细胞的可视化。
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公开(公告)号：US20110150764A1
公开(公告)日：2011-06-23
申请号：US12995934
申请日：2009-06-02
申请人： Byung-Heon Lee , In San Kim , Hyung Soo Han , Jeong Soo Yoo
发明人： Byung-Heon Lee , In San Kim , Hyung Soo Han , Jeong Soo Yoo
IPC分类号： A61K51/08 , C07K7/06 , C07H21/00 , C12N9/00 , C07C229/08 , A61K49/00 , A61K38/08 , A61K38/43 , A61P9/10
CPC分类号： C07K7/06
摘要： The present invention relates to stroke-targeting peptides and use thereof. More specifically, the present invention relates to a stroke-targeting peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 4 and use thereof. The peptide of the present invention can be specifically bound to stroke cells in the subject, and thus can be effectively used in diagnostic markers and kits for stroke, and compositions for drug delivery specific to stroke and pharmaceutical compositions and compositions for imaging stroke.
摘要翻译： 本发明涉及中风靶向肽及其用途。 更具体地，本发明涉及包含选自SEQ ID NO：1至SEQ ID NO：4的氨基酸序列的中风靶向肽及其用途。 本发明的肽可以特异性地结合到受试者的中风细胞中，因此可以有效地用于中风诊断标记物和试剂盒，以及用于中风特异性药物递送的组合物和用于成像中风的药物组合物和组合物。
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10.发明申请Peptide for diagnosing, preventing and treating atherosclerosis and uses thereof 有权用于诊断，预防和治疗动脉粥样硬化的肽及其用途公开(公告)号：US20090074663A1
公开(公告)日：2009-03-19
申请号：US12009359
申请日：2008-01-18
申请人： Byung Heon Lee , In San Kim , Hai Yan Hong , In Seop So
发明人： Byung Heon Lee , In San Kim , Hai Yan Hong , In Seop So
CPC分类号： G01N33/6893 , C07K7/06 , G01N2800/323
摘要： A peptide for diagnosing, preventing and treating atherosclerosis, and a use thereof, comprising an amino acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2, and a use thereof. The peptide effectively targets atherosclerotic plaques, and binds to IL-4R to thereby exhibit antagonistic effects on IL-4-mediated signaling of cellular inflammatory reaction and survival reaction. The peptide of the present invention can be used for diagnosis of atherosclerosis, prevention and treatment of IL-4-induced inflammatory reaction and prevention and treatment of atherosclerosis which is primarily caused by the inflammatory reaction, as well as for prevention or treatment of atherosclerosis via conjugation with an anti-atherosclerotic drug.
摘要翻译： 用于诊断，预防和治疗动脉粥样硬化的肽及其用途，其包含SEQ ID NO：1或SEQ ID NO：2所示的氨基酸序列及其用途。 该肽有效靶向动脉粥样硬化斑块，并结合IL-4R，从而对IL-4介导的细胞炎症反应和存活反应的信号传导具有拮抗作用。 本发明的肽可用于诊断动脉粥样硬化，预防和治疗IL-4诱导的炎性反应以及主要由炎性反应引起的动脉粥样硬化的预防和治疗，以及预防或治疗动脉粥样硬化通过 与抗动脉粥样硬化药物结合。
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