利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.033 秒)

    Polypeptide specifically bound to phosphatidylserine and the use thereof
    1.
    发明授权
    Polypeptide specifically bound to phosphatidylserine and the use thereof 有权
    特异性结合磷脂酰丝氨酸的多肽及其用途

    公开(公告)号：US08133971B2

    公开(公告)日：2012-03-13

    申请号：US12391857

    申请日：2009-02-24

    申请人： Byung-Heon Lee ,  In-San Kim ,  Thapa Narendra

    发明人： Byung-Heon Lee ,  In-San Kim ,  Thapa Narendra

    IPC分类号： C07K5/10

    CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

    摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

    摘要翻译： 本发明涉及与磷脂酰丝氨酸特异性结合的多肽及其用途，更具体地说涉及具有指定为序列号1并特异性结合磷脂酰丝氨酸的氨基酸序列的多肽，含有多肽作为活性成分的磷脂酰丝氨酸检测组合物， 通过使用多肽检测磷脂酰丝氨酸的方法，包含多肽作为活性成分的凋亡细胞检测，含有多肽作为活性成分的药物递送组合物，用于治疗和预防肿瘤性疾病的组合物，以及用于可视化的组合物 肿瘤区。 具有指定为序列号1的氨基酸序列的多肽与磷脂酰丝氨酸具体结合。 因此，本发明的多肽可用于检测磷脂酰丝氨酸，此外还检测在细胞和肿瘤细胞表面上表达磷脂酰丝氨酸的凋亡细胞，并且还可用于凋亡细胞或肿瘤细胞的可视化。

    Bladder tumor-targeting peptide and use thereof
    2.
    发明授权
    Bladder tumor-targeting peptide and use thereof 有权
    膀胱肿瘤靶向肽及其用途

    公开(公告)号：US07745410B2

    公开(公告)日：2010-06-29

    申请号：US11979624

    申请日：2007-11-06

    申请人： Erkki Ruoslahti ,  Byung-Heon Lee ,  In-San Kim

    发明人： Erkki Ruoslahti ,  Byung-Heon Lee ,  In-San Kim

    IPC分类号： A61K38/08 ,  A61K39/395

    CPC分类号： A61K38/08

    摘要： The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according to the present invention is capable of specific binding to bladder tumor cells in vivo and in vitro. The peptide according to the present invention or an antibody thereof is useful for a marker for the diagnosis of bladder tumors, and for a drug carrier targeting bladder tumor.

    摘要翻译： 本发明涉及膀胱肿瘤靶向肽及其用途。 更具体地，本发明涉及具有由SEQ ID NO：7表示的氨基酸序列的膀胱肿瘤靶向肽及其用途。 根据本发明的肽在体内和体外能够特异性结合膀胱肿瘤细胞。 根据本发明的肽或其抗体可用于膀胱肿瘤的诊断标记物和靶向膀胱肿瘤的药物载体。

    Bladder tumor-targeting peptide and use thereof
    6.
    发明申请
    Bladder tumor-targeting peptide and use thereof 有权
    膀胱肿瘤靶向肽及其用途

    公开(公告)号：US20080139479A1

    公开(公告)日：2008-06-12

    申请号：US11979624

    申请日：2007-11-06

    申请人： Erkki Ruoslahti ,  Byung-Heon Lee ,  In-San Kim

    发明人： Erkki Ruoslahti ,  Byung-Heon Lee ,  In-San Kim

    IPC分类号： A61K38/10 ,  C07K7/08 ,  A61P35/00 ,  C07K16/44

    CPC分类号： A61K38/08

    摘要： The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according to the present invention is capable of specific binding to bladder tumor cells in vivo and in vitro. The peptide according to the present invention or an antibody thereof is useful for a marker for the diagnosis of bladder tumors, and for a drug carrier targeting bladder tumor.

    摘要翻译： 本发明涉及膀胱肿瘤靶向肽及其用途。 更具体地，本发明涉及具有由SEQ ID NO：7表示的氨基酸序列的膀胱肿瘤靶向肽及其用途。 根据本发明的肽在体内和体外能够特异性结合膀胱肿瘤细胞。 根据本发明的肽或其抗体可用于膀胱肿瘤的诊断标记物和靶向膀胱肿瘤的药物载体。

    Monoclonal Antibody to Human TGF-Beta Induced Gene-H3 and Use Thereof
    8.
    发明申请
    Monoclonal Antibody to Human TGF-Beta Induced Gene-H3 and Use Thereof 审中-公开
    人TGF-β诱导的基因H3的单克隆抗体及其用途

    公开(公告)号：US20090068189A1

    公开(公告)日：2009-03-12

    申请号：US11791043

    申请日：2005-11-18

    申请人： Eun-Hee Bae ,  In-San Kim ,  Dong-Sin Lee ,  Hee-Jeong Yun

    发明人： Eun-Hee Bae ,  In-San Kim ,  Dong-Sin Lee ,  Hee-Jeong Yun

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/06 ,  A61K35/12 ,  A61P31/00 ,  G01N33/566 ,  G01N33/53 ,  C40B30/04

    CPC分类号： C07K16/18 ,  C07K2317/76

    摘要： The present invention relates to a monoclonal antibody to human βig-h3 and the use thereof. More particularly, it relates to a monoclonal antibody to the human βig-h3 protein, wherein the epitope of the monoclonal antibody is the H1 region of the fourth fas-1 domain of the human βig-h3 protein. The monoclonal antibody can specifically recognize the human βig-h3 protein in tissue, and so will be useful in diagnosing a disease associated with the increase or decrease of the βig-h3 protein. In addition, the monoclonal antibody has the effect of inhibiting the cell adhesion activity of the βig-h3 protein.

    摘要翻译： 本发明涉及对人β-h3的单克隆抗体及其用途。 更具体地说，本发明涉及对人β-h3蛋白的单克隆抗体，其中单克隆抗体的表位是人β-h3蛋白的第四个fas-1结构域的H1区。 单克隆抗体可以特异性识别组织中的人βIG-h3蛋白，因此可用于诊断与βig-h3蛋白的增加或减少相关的疾病。 此外，单克隆抗体具有抑制β-h3蛋白的细胞粘附活性的作用。

    Method for cell adhesion and wound healing
    9.
    发明授权
    Method for cell adhesion and wound healing 失效
    细胞粘附和伤口愈合的方法

    公开(公告)号：US07396682B2

    公开(公告)日：2008-07-08

    申请号：US10276479

    申请日：2000-12-08

    申请人： In-San Kim ,  Jung-Eun Kim

    发明人： In-San Kim ,  Jung-Eun Kim

    IPC分类号： C12N5/00 ,  C07K2/00 ,  C07K14/00 ,  C07K17/02 ,  C07H21/04

    CPC分类号： C07K14/78 ,  A61K38/00

    摘要： The present invention relates to a method for cell adhesion and wound healing with internal domains of βig-h3. Particularly, the present invention relates to the method of using recombinant proteins comprising one or more of 2nd or 4th internal domain of βig-h3 for cell adhesion and wound healing, wherein the 2nd or 4th internal domain of βig-h3 has aspartic acid and isoleucine essential for interaction with integrin which represent a high homology in base sequence of βig-h3 internal domains. The recombinant proteins comprising one or more 2nd or 4th internal domain of βig-h3 are effective for cell adhesion and wound healing by itself and can be used for developing cell culture medium and wound healing agent.

    摘要翻译： 本发明涉及一种细胞粘附和伤口愈合方法，内部结构域为β-h3。 特别地，本发明涉及使用包含βig-h3的第二和/或第四/第四内部结构域中的一个或多个的重组蛋白的方法用于细胞粘附和伤口愈合， 其中βig-h3的第二个或第四个或第四个内部结构域具有与整合素相互作用所必需的天冬氨酸和异亮氨酸，其表示βig-h3内部碱基序列的高度同源性 域名 包含β1-h3的一个或多个第二和/或第四/第四内部结构域的重组蛋白自身有效用于细胞粘附和伤口愈合，并且可用于开发细胞培养物 培养和伤口愈合剂。

    Peptides and derivatives thereof showing cell attachment, spreading and detachment activity
    10.
    发明授权
    Peptides and derivatives thereof showing cell attachment, spreading and detachment activity 失效
    肽及其衍生物显示细胞附着，扩散和分离活性

    公开(公告)号：US07250400B2

    公开(公告)日：2007-07-31

    申请号：US11307490

    申请日：2006-02-09

    申请人： In-San Kim ,  Jung-Eun Kim

    发明人： In-San Kim ,  Jung-Eun Kim

    IPC分类号： A61K38/00 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12P21/06 ,  C07K1/00

    CPC分类号： A61K38/08 ,  C07K7/06 ,  C07K14/4718 ,  C07K14/78

    摘要： The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL (SEQ ID NO:2) and EPDIM (SEQ ID NO:3) and derivatives thereof which promote the cell attachment activity through interaction with α3β1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing βig-h3, wound healing, tissue regeneration and metastasis inhibition.

    摘要翻译： 本发明涉及具有细胞附着，扩散和分离活性的肽及其衍生物。 特别地，本发明涉及通过与作为功能性细胞受体的α3β1整联蛋白相互作用而促进细胞附着活性的肽NKDIL（SEQ ID NO：2）和EPDIM（SEQ ID NO：3）及其衍生物，包括天冬氨酸和 异亮氨酸对细胞附着和分离活性至关重要。 本发明的肽及其衍生物可用于开发通过含有β-h3的各种细胞外基质蛋白，伤口愈合，组织再生和转移抑制介导的细胞附着活性的研究。