Abstract:
The present disclosure provides pharmaceutical compositions comprising cytidine analogs for oral administration, wherein the compositions release the cytidine analog substantially in the stomach. Also provided are methods of treating diseases and disorders using the oral formulations provided herein.
Abstract:
The invention relates to an electrical machine of the transversal-flux type. The machine comprises a stator and a movable element. The stator has a plurality of stator elements with magnetic flux conductors and an electric winding extending in a closed winding path through each magnetic flux conductor. The movable element comprises a number of permanent-magnet members and is movable in relation to the stator along a movement path. The winding path comprises a first current-carrying section extending along the movement path. Each magnetic flux conductor forms, together with one of the permanent-magnet members, a closed magnetic flux circuit around said current-carrying section. Each permanent-magnet member comprises a primary magnet with a magnetic direction across the movement path. Adjacently located permanent-magnet members are separated from each other by an intermediate member comprising at least one secondary magnet that has a magnetic direction essentially across the magnetic direction of the primary magnet.
Abstract:
The present disclosure provides pharmaceutical compositions comprising cytidine analogs, for example, 5-azacytidine or decitabine, for oral administration, wherein the compositions release the cytidine analog, for example, 5-azacytidine or decitabine, substantially in the stomach. Also provided are methods of treating diseases and disorders using the oral formulations provided herein.
Abstract:
A hybrid drive system includes an internal combustion engine with an output shaft. An energy converter is connected to the output shaft via a coupling. The energy converter has first and second rotors which are rotatable at different speeds in relation to each other. At least one of the rotors is provided with one or more windings which are supplied with current from a current converter. The current converter is supplied with direct current from a direct current source. A transmission with variable gear ratio is coupled to one of the rotors. The transmission and the current converter cooperate via a control arrangement. The control arrangement comprises a control unit for controlling rotational speed and torque of the internal combustion engine and the energy converter.
Abstract:
The present invention relates to polymer particles and uses thereof. The polymer particle may comprise a polymer selected from poly-beta-amino acids, polylactates, polythioesters and polyesters. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof. The methods, polymer particles and fusion proteins of the present invention have utility in diagnostics, protein production, biocatalyst immobilisation, and drug delivery.
Abstract:
The present invention provides methods of treating a patient having a higher risk myelodysplastic syndrome, which comprises administering to a patient having a higher risk myelodysplastic syndrome a therapeutically effective amount of a cytidine analog. The cytidine analog includes 5-aza-2′-deoxy cytidine, 5-azacytidine, 5-aza-2′-deoxy- 2′,2′-difluorocytidine, 5-aza-2-40 -deoxy-2′-fluorocytidine, 2′-deoxy-2′,2′-difluorocytidine, cytosine 1-β-D-arabinofuranoside, 2(1H) pyrimidine riboside, 2′-cyclocytidine, arabinofuanosyl-5-azacytidine, dihydro-5-azacytidine, N4-octadecyl-cytarabine, and elaidic acid cytarabine