-
公开(公告)号：US08993742B2
公开(公告)日：2015-03-31
申请号：US12973624
申请日：2010-12-20
Applicant: Thomas David Reed
Inventor： Thomas David Reed
CPC classification number: C07K14/47
Abstract: The invention relates to polarized cell tubulo-vesicular structure localization signals. The localization signals are utilized as research tools or are linked to polypeptides of interest or therapeutic molecules. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other macromolecules to the tubulo-vesicular structures of polarized cells. The polypeptides of the invention optionally include linkage to reporters, epitopes and/or other experimental or therapeutic molecules. The invention also encompasses polynucleotides encoding the localization signals and vectors comprising these polynucleotides.
-
公开(公告)号：US08679784B2
公开(公告)日：2014-03-25
申请号：US13491315
申请日：2012-06-07
Applicant: Thomas David Reed , Amy H. Atzel
Inventor： Thomas David Reed , Amy H. Atzel
CPC classification number: A61K38/16 , A61K48/00 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K2319/02 , C07K2319/41 , C12N1/20 , C12N15/10 , C12N15/62
Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节mTOR活性的配体，均聚配体和杂多糖配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
-
公开(公告)号：US20090186379A1
公开(公告)日：2009-07-23
申请号：US11983235
申请日：2007-11-08
Applicant: Thomas David Reed
Inventor： Thomas David Reed
CPC classification number: C07K14/001 , C07K14/47 , C07K2319/21 , C07K2319/43 , C07K2319/60 , C12N15/62 , C12N15/85
Abstract: The invention relates to kinase inhibitor ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate ERK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶抑制剂配体和聚合配体。 特别地，本发明涉及调节ERK活性的配体和聚合配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
-
公开(公告)号：US20190069467A1
公开(公告)日：2019-03-07
申请号：US16181322
申请日：2018-11-05
Applicant: Thomas David Reed
Inventor： Thomas David Reed
CPC classification number: A01B49/02 , A01B49/022 , A01G3/062 , A01G20/12
Abstract: Described herein is a combination apparatus and methods of using the combination apparatus. The combination apparatus is operable as both an edger and a sod cutter. The combination apparatus includes an arm that oscillates when driven by a motor. Both a sod cutter blade and an edger blade are coupled to the arm.
-
5.发明授权Polynucleotides encoding extracellular-signal-regulated kinase (ERK) heteropolyligand polypeptides 有权编码细胞外信号调节激酶（ERK）杂多肽多肽的多核苷酸公开(公告)号：US09255125B2
公开(公告)日：2016-02-09
申请号：US13612458
申请日：2012-09-12
Applicant: Thomas David Reed
Inventor： Thomas David Reed
CPC classification number: C07K14/001 , C07K14/47 , C07K2319/21 , C07K2319/43 , C07K2319/60 , C12N15/62 , C12N15/85
Abstract: The invention relates to kinase inhibitor ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate ERK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶抑制剂配体和聚合配体。 特别地，本发明涉及调节ERK活性的配体和聚合配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
-
Patent Agency Ranking
公开(公告)号：US10548252B2
公开(公告)日：2020-02-04
申请号：US16181322
申请日：2018-11-05
Applicant: Thomas David Reed
Inventor： Thomas David Reed
Abstract: Described herein is a combination apparatus and methods of using the combination apparatus. The combination apparatus is operable as both an edger and a sod cutter. The combination apparatus includes an arm that oscillates when driven by a motor. Both a sod cutter blade and an edger blade are coupled to the arm.
-
公开(公告)号：US10117372B1
公开(公告)日：2018-11-06
申请号：US15131734
申请日：2016-04-18
Applicant: Thomas David Reed
Inventor： Thomas David Reed
Abstract: Described herein is a combination apparatus and methods of using the combination apparatus. The combination apparatus is operable as both an edger and a sod cutter. The combination apparatus includes an arm that oscillates when driven by a motor. Both a sod cutter blade and an edger blade are coupled to the arm.
-
公开(公告)号：US08729225B2
公开(公告)日：2014-05-20
申请号：US11937685
申请日：2007-11-09
Applicant: Thomas David Reed , Amy H. Atzel
Inventor： Thomas David Reed , Amy H. Atzel
CPC classification number: C12N9/1051 , C07K14/47 , C12N15/85
Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate GSK3 activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节GSK3活性的配体和聚合配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
-
公开(公告)号：US20130244329A1
公开(公告)日：2013-09-19
申请号：US13491315
申请日：2012-06-07
Applicant: Thomas David REED , Amy H. Atzel
Inventor： Thomas David REED , Amy H. Atzel
IPC: C07K14/47
CPC classification number: A61K38/16 , A61K48/00 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K2319/02 , C07K2319/41 , C12N1/20 , C12N15/10 , C12N15/62
Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
-
10.发明授权公开(公告)号：US08283445B2
公开(公告)日：2012-10-09
申请号：US11983235
申请日：2007-11-08
Applicant: Thomas David Reed
Inventor： Thomas David Reed
CPC classification number: C07K14/001 , C07K14/47 , C07K2319/21 , C07K2319/43 , C07K2319/60 , C12N15/62 , C12N15/85
Abstract: The invention relates to kinase inhibitor ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate ERK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶抑制剂配体和聚合配体。 特别地，本发明涉及调节ERK活性的配体和聚合配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
-
-
-
-
-
-
-
-
-
Search Results
18
records
(took 0.019 seconds)
