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    Tubulo-vesicular structure localization signals
    1.
    发明申请
    Tubulo-vesicular structure localization signals 审中-公开
    管状囊泡结构定位信号

    公开(公告)号：US20090181458A1

    公开(公告)日：2009-07-16

    申请号：US11999143

    申请日：2007-12-04

    Applicant: Thomas David Reed

    Inventor： Thomas David Reed

    IPC: C12N15/87 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06

    CPC classification number: C07K14/47

    Abstract: The invention relates to polarized cell tubulo-vesicular structure localization signals. The localization signals are utilized as research tools or are linked to polypeptides of interest or therapeutic molecules. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other macromolecules to the tubulo-vesicular structures of polarized cells. The polypeptides of the invention optionally include linkage to reporters, epitopes and/or other experimental or therapeutic molecules. The invention also encompasses polynucleotides encoding the localization signals and vectors comprising these polynucleotides.

    Abstract translation: 本发明涉及极化细胞肾小管结构定位信号。 本地化信号被用作研究工具或与感兴趣的多肽或治疗分子连接。 公开了制备和使用多肽和修饰的多肽作为将治疗剂，实验化合物，肽，蛋白质和/或其他大分子定位于极化细胞的肾小管结构的信号的方法。 本发明的多肽任选地包括与记者，表位和/或其他实验或治疗分子的连接。 本发明还包括编码定位信号的多核苷酸和包含这些多核苷酸的载体。

    Tubulo-vesicular structure localization signals
    4.
    发明授权
    Tubulo-vesicular structure localization signals 有权

    公开(公告)号：US08993742B2

    公开(公告)日：2015-03-31

    申请号：US12973624

    申请日：2010-12-20

    Applicant: Thomas David Reed

    Inventor： Thomas David Reed

    IPC: C07H21/04 ,  C12N15/62 ,  C12P21/00 ,  C12P21/02 ,  C07K14/47

    CPC classification number: C07K14/47

    Abstract: The invention relates to polarized cell tubulo-vesicular structure localization signals. The localization signals are utilized as research tools or are linked to polypeptides of interest or therapeutic molecules. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other macromolecules to the tubulo-vesicular structures of polarized cells. The polypeptides of the invention optionally include linkage to reporters, epitopes and/or other experimental or therapeutic molecules. The invention also encompasses polynucleotides encoding the localization signals and vectors comprising these polynucleotides.

    mTOR ligands and polynucleotides encoding mTOR ligands
    5.
    发明授权
    mTOR ligands and polynucleotides encoding mTOR ligands 有权
    mTOR配体和编码mTOR配体的多核苷酸

    公开(公告)号：US08679784B2

    公开(公告)日：2014-03-25

    申请号：US13491315

    申请日：2012-06-07

    Applicant: Thomas David Reed ,  Amy H. Atzel

    Inventor： Thomas David Reed ,  Amy H. Atzel

    IPC: C12P21/06 ,  C07H21/02

    CPC classification number: A61K38/16 ,  A61K48/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/4703 ,  C07K2319/02 ,  C07K2319/41 ,  C12N1/20 ,  C12N15/10 ,  C12N15/62

    Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.

    Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节mTOR活性的配体，均聚配体和杂多糖配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。

    ERK ligands and polynucleotides encoding ERK ligands
    6.
    发明申请
    ERK ligands and polynucleotides encoding ERK ligands 有权
    ERK配体和编码ERK配体的多核苷酸

    公开(公告)号：US20090186379A1

    公开(公告)日：2009-07-23

    申请号：US11983235

    申请日：2007-11-08

    Applicant: Thomas David Reed

    Inventor： Thomas David Reed

    IPC: C12P21/02 ,  C07K14/47 ,  C12N15/12 ,  C12N15/85 ,  C12N5/10 ,  A01K67/027 ,  C07H21/04

    CPC classification number: C07K14/001 ,  C07K14/47 ,  C07K2319/21 ,  C07K2319/43 ,  C07K2319/60 ,  C12N15/62 ,  C12N15/85

    Abstract: The invention relates to kinase inhibitor ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate ERK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.

    Abstract translation: 本发明涉及激酶抑制剂配体和聚合配体。 特别地，本发明涉及调节ERK活性的配体和聚合配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。

    GSK3 LIGANDS AND POLYNUCLEOTIDES ENCODING GSK3 LIGANDS
    8.
    发明申请
    GSK3 LIGANDS AND POLYNUCLEOTIDES ENCODING GSK3 LIGANDS 有权
    GSK3配体和多核苷酸编码GSK3配体

    公开(公告)号：US20080213834A1

    公开(公告)日：2008-09-04

    申请号：US11937685

    申请日：2007-11-09

    Applicant: Thomas David Reed ,  Amy H. Atzel

    Inventor： Thomas David Reed ,  Amy H. Atzel

    IPC: C12P21/04 ,  C07K16/00 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00

    CPC classification number: C12N9/1051 ,  C07K14/47 ,  C12N15/85

    Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate GSK3 activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.

    Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节GSK3活性的配体和聚合配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。

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