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公开(公告)号：US09077670B2
公开(公告)日：2015-07-07
申请号：US12969228
申请日：2010-12-15
IPC分类号： H04B7/204 , H04L12/911
CPC分类号： H04L47/28 , H04L47/805 , H04L47/826
摘要： A deadline-aware network protocol is described. In an example, data transfer at a transport layer entity of a packet-based communication network is controlled by receiving a request for network resources for a data flow from a network element and allocating network resources to the data flow. The data flow comprises a number of data packets associated with an application, and the request comprises a factor relating to a time deadline associated with the application. The network resources allocated depend on the factor relating to the time deadline. In examples, the network resource can be a bandwidth or data rate allocated to the data flow, and the factor can be a data rate sufficient to complete the data flow within the time deadline. In examples, the network resources are allocated greedily, such that requests are fully satisfied whenever possible, and the network resources are fully utilized.
摘要翻译： 描述了一个截止日期的网络协议。 在一个示例中，通过从网元接收对数据流的网络资源的请求并且将网络资源分配给数据流来控制在基于分组的通信网络的传输层实体处的数据传输。 数据流包括与应用相关联的多个数据分组，并且该请求包括与应用相关联的时间限制的因素。 分配的网络资源取决于与时间限制有关的因素。 在示例中，网络资源可以是分配给数据流的带宽或数据速率，并且该因子可以是足以在时间段内完成数据流的数据速率。 在示例中，网络资源被贪婪地分配，使得尽可能完全满足请求，并且网络资源被充分利用。
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公开(公告)号：US20090190599A1
公开(公告)日：2009-07-30
申请号：US12022902
申请日：2008-01-30
IPC分类号： H04L12/56
CPC分类号： H04L61/6068 , H04L29/12933 , H04L67/1074 , H04L67/1076 , H04L69/40
摘要： Sampling rules for information dissemination are described which may be applied in a system containing a number of nodes arranged into groups. A target address is selected using one of two methods: selection of an address from the entire address space of the system and selection of an address from a part of the address space which corresponds to set of groups of nodes. The set of groups of nodes is updated when information is successfully disseminated to a node at a target address selected using the first of the two methods. Rules to determine which of the two methods are used for any particular selection operation are also described.
摘要翻译： 描述了用于信息传播的采样规则，其可以应用于包含排列成组的多个节点的系统中。 使用以下两种方法之一来选择目标地址：从系统的整个地址空间中选择一个地址，并从对应于一组节点的地址空间的一部分中选择一个地址。 当信息成功传播到使用两种方法中的第一种选择的目标地址处的节点时，更新节点组的集合。 还描述了确定两种方法中的哪一种用于任何特定选择操作的规则。
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公开(公告)号：US20070140970A1
公开(公告)日：2007-06-21
申请号：US10590784
申请日：2005-02-25
IPC分类号： A61K49/00 , A61K39/395 , C07K16/46
CPC分类号： A61K51/0459 , A61K31/4184 , C07C45/292 , C07D235/20 , C07C47/55
摘要： The present invention relates to cell targeting conjugates and in particular, but not exclusively, to methods of their use in selectively eliminating and in selectively imaging target cells. The invention also relates to processes for production of the conjugates and to intermediate compounds that may be used in production of a specific class of cell targeting conjugates. In one embodiment there is provided a cell targeting conjugate comprising the following components that are covalently conjugated via a linker that is degradable within the target cells: i) a DNA minor groove binding ligand incorporating an effective Auger electron-emitting and/or gamma-emitting and/or positron-emitting atom or photoactive moiety; ii) a target cell specific protein or peptide that is capable of internalisation by target cells.
摘要翻译： 本发明涉及细胞靶向缀合物，特别是但不排他地涉及它们用于选择性地消除和选择性地成像靶细胞的方法。 本发明还涉及可用于生产特定类别的细胞靶向缀合物的缀合物和中间体化合物的制备方法。 在一个实施方案中，提供了细胞靶向缀合物，其包含通过可在靶细胞内可降解的接头共价共轭的以下成分：i）掺入有效俄歇电子发射和/或γ发射的DNA小沟结合配体 和/或正电子发射原子或光活性部分; ii）能够靶细胞内化的靶细胞特异性蛋白质或肽。
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4.发明授权Compositions for anti-inflammatory, antioxidant effects and improved respiratory function by specific histone deacetylase inhibition 有权抗炎，抗氧化作用的组合物和特定的组蛋白脱乙酰酶抑制改善呼吸功能公开(公告)号：US09532970B2
公开(公告)日：2017-01-03
申请号：US14793839
申请日：2015-07-08
IPC分类号： A61K31/26 , C07C331/20 , A61K45/06 , A61K31/05 , A61K31/198 , A61K31/7048
CPC分类号： A61K31/26 , A61K31/05 , A61K31/198 , A61K31/7048 , A61K45/06 , A61P11/00 , A61P29/00 , C07C331/20 , A61K2300/00
摘要： Compositions comprising LSF compositions and treatment regiments comprising administration of LSF containing compositions are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, including diseases associated with inflammation and/or oxidative stress, are provided. Various methods for use of the LSF compositions for inhibition of histone deacetylases (HDACs) in various cells, tissues, and/or conditions are also provided.
摘要翻译： 公开了包含LSF组合物和包含施用含LSF的组合物的治疗团的组合物。 组合物和/或团可任选地包括施用维生素，矿物质和抗氧化剂。 提供了使用这些组合物和治疗方案治疗受试者疾病（包括与炎症和/或氧化应激相关的疾病）的方法。 还提供了在各种细胞，组织和/或条件中使用LSF组合物抑制组蛋白脱乙酰酶（HDAC）的各种方法。
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公开(公告)号：US09407693B2
公开(公告)日：2016-08-02
申请号：US11866811
申请日：2007-10-03
申请人： Sandeep Kishan Singhal , Peter Bernard Key , Ming Zhang , Guobin Shen , Thomas Karagiannis , Ayalvadi Jagannathan Ganesh
发明人： Sandeep Kishan Singhal , Peter Bernard Key , Ming Zhang , Guobin Shen , Thomas Karagiannis , Ayalvadi Jagannathan Ganesh
IPC分类号： G06F15/173 , H04L29/08
CPC分类号： H04L67/104 , H04L67/1065 , H04L67/1072 , H04L67/327
摘要： Using location-independent names to identify content, a service for mapping endpoint requests to requested content. Content requested by an endpoint of the network is mapped to a dynamic “swarm” of server, peer, or other endpoints capable of supporting the content download. Content names are mapped to a dynamically generated content swarm, presenting a current set of hosts, which can provide the requested content. Optionally, varying degrees of explicit visibility into routing paths and the performance tradeoffs between those routing paths is supported. Based on a set of class of service parameters for a given request for content, a host can initiate route selection based on class of service parameters, predicated on routing metrics maintained by the network by cooperating endpoints and/or network routers.
摘要翻译： 使用与位置无关的名称来标识内容，将端点请求映射到请求的内容的服务。 由网络的端点请求的内容被映射到能够支持内容下载的服务器，对等端或其他端点的动态“群”。 内容名称被映射到动态生成的内容群，呈现当前的一组主机，可以提供所请求的内容。 可选地，支持对路由路径的不同程度的显式可见性以及这些路由路径之间的性能折衷。 基于针对内容的给定请求的一组服务参数类型，主机可以基于服务类别参数来启动路由选择，基于由协作端点和/或网络路由器由网络维护的路由度量。
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6.发明申请HYDROXYTYROSOL AND OLEUROPEIN COMPOSITIONS FOR INDUCTION OF DNA DAMAGE, CELL DEATH AND LSD1 INHIBITION 有权用于诱导DNA损伤，细胞死亡和LSD1抑制的羟基恶唑啉和奥伦膦酸盐组合物公开(公告)号：US20150342903A1
公开(公告)日：2015-12-03
申请号：US14823028
申请日：2015-08-11
IPC分类号： A61K31/05 , A61K31/7048 , A61K31/704
CPC分类号： A61K31/05 , A61K31/22 , A61K31/704 , A61K31/7048 , A61K45/06 , A61K2300/00 , C12Q1/26 , C12Q1/6876 , G01N33/574
摘要： Compositions comprising hydroxytyrosol-containing formulations and treatment regiments comprising hydroxytyrosol and/or oleuropein and chemotherapeutic agents are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, such as a malignancy, and for inducing or enhancing angiogenesis, treating or preventing oxidative stress, for treating or preventing high glucose-induced dysfunction, treating or preventing chemotherapy-induced dysfunction, and for improving cell viability are provided. Various methods for use of the hydroxytyrosol compositions for inhibition of lysine specific demethylase 1 (LSD1) in various cancers are also provided.
摘要翻译： 公开了包含含羟基酪醇的制剂和包含羟基酪醇和/或橄榄苷和化学治疗剂的治疗组的组合物。 组合物和/或团可任选地包括施用维生素，矿物质和抗氧化剂。 使用这些组合物和治疗方案治疗受试者的疾病如恶性肿瘤，以及用于诱导或增强血管发生，治疗或预防氧化应激，治疗或预防高葡萄糖诱导的功能障碍，治疗或预防化学疗法诱导的功能障碍的方法， 并提供用于改善细胞存活力。 还提供了使用羟基酪醇组合物抑制各种癌症中赖氨酸特异性脱甲基酶1（LSD1）的各种方法。
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公开(公告)号：US08886731B2
公开(公告)日：2014-11-11
申请号：US13150535
申请日：2011-06-01
CPC分类号： H04W88/04
摘要： A decentralized relaying algorithm for mobile devices is described. In an embodiment, a mobile device acts as a relay within a network of mobile devices and on contact with a source device downloads messages from the source according to a locally stored relaying probability for each channel of information within the network. These messages are subsequently downloaded to another device which is the end user of the message. Where the relay does not download the message from the source as a result of the decision made based on the relaying probability, a virtual message is downloaded which comprises metadata only and not the payload of the message. The relay updates the stored relaying probabilities for each channel based on locally observable information which includes feedback received from mobile devices to which the relay has downloaded messages. The feedback identifies unique paths for the payload of messages through the network.
摘要翻译： 描述了用于移动设备的分散中继算法。 在一个实施例中，移动设备充当移动设备的网络内的中继器，并且在与源设备接触的情况下，根据网络内的每个信道信道的本地存储的中继概率来从源下载消息。 这些消息随后被下载到消息的最终用户的另一设备。 由于作为基于中继概率的决定的结果，中继器不从源地下载消息，所以下载虚拟消息，其仅包含元数据而不是消息的有效载荷。 继电器基于本地可观察到的信息更新每个信道的存储的中继概率，该信息包括从中继已下载消息的移动设备接收到的反馈。 反馈通过网络识别消息有效载荷的唯一路径。
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8.发明申请HYDROXYTYROSOL AND OLEUROPEIN COMPOSITIONS FOR INDUCTION OF DNA DAMAGE, CELL DEATH AND LSD1 INHIBITION 审中-公开用于诱导DNA损伤，细胞死亡和LSD1抑制的羟基恶唑啉和奥伦膦酸盐组合物公开(公告)号：US20140155339A1
公开(公告)日：2014-06-05
申请号：US14091742
申请日：2013-11-27
IPC分类号： A61K31/05 , A61K31/7048 , C12Q1/37 , C12Q1/68 , G01N33/574 , A61K31/704
CPC分类号： A61K31/05 , A61K31/22 , A61K31/704 , A61K31/7048 , A61K45/06 , A61K2300/00 , C12Q1/26 , C12Q1/6876 , G01N33/574
摘要： Compositions comprising hydroxytyrosol-containing formulations and treatment regiments comprising hydroxytyrosol and/or oleuropein and chemotherapeutic agents are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, such as a malignancy, and for inducing or enhancing angiogenesis, treating or preventing oxidative stress, for treating or preventing high glucose-induced dysfunction, treating or preventing chemotherapy-induced dysfunction, and for improving cell viability are provided. Various methods for use of the hydroxytyrosol compositions for inhibition of lysine specific demethylase 1 (LSD1) in various cancers are also provided.
摘要翻译： 公开了包含含羟基酪醇的制剂和包含羟基酪醇和/或橄榄苷和化学治疗剂的治疗组的组合物。 组合物和/或团可任选地包括施用维生素，矿物质和抗氧化剂。 使用这些组合物和治疗方案治疗受试者的疾病如恶性肿瘤，以及用于诱导或增强血管发生，治疗或预防氧化应激，治疗或预防高葡萄糖诱导的功能障碍，治疗或预防化学疗法诱导的功能障碍的方法， 并提供用于改善细胞存活力。 还提供了使用羟基酪醇组合物抑制各种癌症中赖氨酸特异性脱甲基酶1（LSD1）的各种方法。
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公开(公告)号：US20120158858A1
公开(公告)日：2012-06-21
申请号：US12969963
申请日：2010-12-16
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： H04L51/22
摘要： Resource optimization for online services is described. In one example, objects (such as mailboxes or other data associated with an online service) are assigned to network elements (such as servers) by inferring a relationship graph from log data relating to usage of the online service. The graph has a node for each object, and connections between each pair of objects having data items in common. Each connection has a weight relating to the number of common data items. The graph is partitioned into a set of clusters, such that each cluster has nodes joined by connections with a high weight relative to the weight of connections between nodes in different clusters. The objects are then distributed to the network elements such that objects corresponding to nodes in the same cluster are located on the same network element.
摘要翻译： 描述了在线服务的资源优化。 在一个示例中，通过从与在线服务的使用相关的日志数据推断关系图，将对象（诸如邮箱或与在线服务相关联的其他数据）分配给网络元件（例如服务器）。 该图具有每个对象的节点，以及具有共同数据项的每对对象之间的连接。 每个连接具有与公共数据项的数量相关的权重。 该图被划分成一组集群，使得每个集群具有通过具有相对于不同集群中的节点之间的连接的权重的高权重的连接而连接的节点。 然后将对象分发到网络元件，使得与相同集群中的节点相对应的对象位于同一网络元件上。
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公开(公告)号：US08059541B2
公开(公告)日：2011-11-15
申请号：US12125325
申请日：2008-05-22
IPC分类号： G01R31/08
CPC分类号： H04L43/0817 , H04L41/14 , H04L43/026 , H04L47/10 , H04L47/125
摘要： An end-host based network management system and methods are described. The methods are performed independently at each end-host within the network based on data on local flows which is shared between end-hosts. In an embodiment, an end-host shares data on constrained local flows with other end-hosts and receives such data from other end-hosts. Based on this data, the end-host determines which flows from other nodes are competing for a shared resource with a constrained local flow and allocates the capacity of the shared resource between all the competing flows. This allocation is then enforced for the local flow by the end-host. Other end-hosts with competing flows perform similar methods and through an iterative process the contention for the shared resource is resolved and the utilization of the shared resource is optimized.
摘要翻译： 描述基于终端主机的网络管理系统和方法。 基于在终端主机之间共享的本地流的数据，在网络内的每个终端主机上独立地执行这些方法。 在一个实施例中，终端主机与其他终端主机共享受限本地流上的数据，并从其他终端主机接收这样的数据。 基于该数据，终端主机确定来自其他节点的哪些流量与受约束的本地流竞争共享资源，并在所有竞争流之间分配共享资源的容量。 然后，该分配由终端主机强制执行本地流。 具有竞争流的其他终端主机执行类似的方法，并通过迭代过程解决共享资源的争用，并优化共享资源的利用。
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