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公开(公告)号:US08536307B2
公开(公告)日:2013-09-17
申请号:US13423666
申请日:2012-03-19
申请人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
发明人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
IPC分类号: A61K38/00
CPC分类号: C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要: The invention relates to the production of novel proteins exhibiting binding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using genetic engineering methods. Like immunoglobulin, the anticalin thus obtained can be used to identify or bind molecular structures.
摘要翻译: 本发明涉及对某些配体表现出结合活性的新蛋白质的生产,即所谓的抗蛋白质。 为此,利用遗传工程方法,通过氨基酸置换在其天然配体结合口袋中修饰脂笼蛋白家族的肽结构。 像免疫球蛋白一样,如此得到的anticalin可用于鉴定或结合分子结构。
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公开(公告)号:US20100285564A1
公开(公告)日:2010-11-11
申请号:US12654809
申请日:2010-01-05
申请人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
发明人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
CPC分类号: C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要: The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
摘要翻译: 本发明涉及对某些配体表现出结合活性的新蛋白质的生产,即所谓的抗蛋白质。 为此,脂笼蛋白家族的肽结构通过使用通用工程方法的天然配体结合口袋中的氨基酸替换来修饰。 如此获得的相似免疫球蛋白可以用于鉴定或结合分子结构。
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公开(公告)号:US07723476B2
公开(公告)日:2010-05-25
申请号:US11224071
申请日:2005-09-13
申请人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
发明人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
IPC分类号: A61K38/00
CPC分类号: C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要: The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
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公开(公告)号:US07250297B1
公开(公告)日:2007-07-31
申请号:US09509444
申请日:1998-09-25
申请人: Gerald Beste , Thomas Stibora , Arne Skerre , Frank Schmidt
发明人: Gerald Beste , Thomas Stibora , Arne Skerre , Frank Schmidt
CPC分类号: C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要: The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using genetic engineering methods. A like immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
摘要翻译: 本发明涉及对某些配体表现出结合活性的新蛋白质的生产,即所谓的抗蛋白质。 为此,利用遗传工程方法,通过氨基酸置换在其天然配体结合口袋中修饰脂笼蛋白家族的肽结构。 类似的免疫球蛋白,所得到的anticalin可用于鉴定或结合分子结构。
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公开(公告)号:US20120244596A1
公开(公告)日:2012-09-27
申请号:US13423666
申请日:2012-03-19
申请人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
发明人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
IPC分类号: C07K14/47 , C07K16/00 , C07K14/775 , C07K19/00 , C12N9/96
CPC分类号: C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要: The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
摘要翻译: 本发明涉及对某些配体表现出结合活性的新蛋白质的生产,即所谓的抗蛋白质。 为此,脂笼蛋白家族的肽结构通过使用通用工程方法的天然配体结合口袋中的氨基酸替换来修饰。 如此获得的相似免疫球蛋白可以用于鉴定或结合分子结构。
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公开(公告)号:US08158753B2
公开(公告)日:2012-04-17
申请号:US12654809
申请日:2010-01-05
申请人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
发明人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
IPC分类号: A61K38/00
CPC分类号: C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要: The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
摘要翻译: 本发明涉及对某些配体表现出结合活性的新蛋白质的生产,即所谓的抗蛋白质。 为此,脂笼蛋白家族的肽结构通过使用通用工程方法的天然配体结合口袋中的氨基酸替换来修饰。 如此获得的相似免疫球蛋白可以用于鉴定或结合分子结构。
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公开(公告)号:US20060058510A1
公开(公告)日:2006-03-16
申请号:US11224071
申请日:2005-09-13
申请人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
发明人: Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
IPC分类号: C07K14/775
CPC分类号: C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要: The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
摘要翻译: 本发明涉及对某些配体表现出结合活性的新蛋白质的生产,即所谓的抗蛋白质。 为此,脂笼蛋白家族的肽结构通过使用通用工程方法的天然配体结合口袋中的氨基酸替换来修饰。 如此获得的相似免疫球蛋白可以用于鉴定或结合分子结构。
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