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9 条记录 (耗时 0.018 秒)

    Method of Inducing Cleavage of Amyloid Precursor Protein to Form a Novel Fragment
    5.
    发明申请
    Method of Inducing Cleavage of Amyloid Precursor Protein to Form a Novel Fragment 审中-公开
    诱导淀粉样前体蛋白切割形成新片段的方法

    公开(公告)号：US20100168135A1

    公开(公告)日：2010-07-01

    申请号：US12638219

    申请日：2009-12-15

    申请人： Kim Nicholas Green ,  Tilman Oltersdorf ,  Eckard Weber

    发明人： Kim Nicholas Green ,  Tilman Oltersdorf ,  Eckard Weber

    IPC分类号： A61K31/437 ,  A61K31/429 ,  A61K31/519 ,  A61K31/4745 ,  C07K2/00 ,  C12Q1/02

    CPC分类号： A61K31/429 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/519 ,  G01N33/5058

    摘要： The present invention provides a method of inducing cleavage of amyloid precursor protein to produce an approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein in a subject, the method comprising administering a heterocyclic compound or a pharmaceutically acceptable salt, hydrate or prodrug thereof to a subject in need thereof, wherein the approximately 17 kilodalton fragment includes the carboxyterminal amino acid sequence of amyloid precursor protein and amyloid-beta amino acid sequence. Also provided is a screening method for identifying compounds induce cleavage of amyloid precursor protein to produce the approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein.

    摘要翻译： 本发明提供诱导淀粉样蛋白前体蛋白切割以在受试者中产生淀粉样蛋白前体蛋白的约17千道尔顿羧基末端片段的方法，所述方法包括给予杂环化合物或其药学上可接受的盐，水合物或前体药物至 其中约17千道尔顿片段包括淀粉样蛋白前体蛋白和淀粉样蛋白-β氨基酸序列的羧基末端氨基酸序列。 还提供了用于鉴定化合物的筛选方法，诱导淀粉样蛋白前体蛋白的切割以产生淀粉样蛋白前体蛋白的约17千道尔顿羧基末端片段。

    Human bad polypeptides, encoding nucleic acids and methods of use
    6.
    发明授权
    Human bad polypeptides, encoding nucleic acids and methods of use 有权
    人类不良多肽，编码核酸和使用方法

    公开(公告)号：US06824991B2

    公开(公告)日：2004-11-30

    申请号：US09922378

    申请日：2001-08-03

    申请人： William A. Horne ,  Tilman Oltersdorf

    发明人： William A. Horne ,  Tilman Oltersdorf

    IPC分类号： G01N3368

    CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K48/00

    摘要： The invention provides an isolated gene and an isolated nucleic acid sequence encoding human Bad and functional fragments thereof. Also provided is an isolated human Bad polypeptide and functional fragments thereof. Methods of identifying human Bad binding partners and methods of screening for compounds which interfere with the association of human Bad interacting polypeptides with human Bad are also provided. Finally, methods for decreasing or increasing the viability of a cell are provided as well.

    摘要翻译： 本发明提供了分离的基因和编码人的坏分子和功能片段的分离的核酸序列。 还提供了分离的人Bad多肽及其功能片段。 还提供了鉴定人Bad结合配偶体的方法和筛选干扰人类坏相互作用多肽与人类Bad的缔合的化合物的方法。 最后，还提供降低或增加细胞活力的方法。