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    Hydrophobic polymer dispersion and process for the preparation thereof
    1.
    发明授权
    Hydrophobic polymer dispersion and process for the preparation thereof 失效
    疏水性聚合物分散体及其制备方法

    公开(公告)号：US06656984B1

    公开(公告)日：2003-12-02

    申请号：US09202981

    申请日：1999-02-24

    申请人： Kristiina Haasmaa ,  Timo Petteri Paronen ,  Arto Olavi Urtti ,  Soili Peltonen ,  Maija Elina Heikkilä ,  Jani Vuorenpää

    发明人： Kristiina Haasmaa ,  Timo Petteri Paronen ,  Arto Olavi Urtti ,  Soili Peltonen ,  Maija Elina Heikkilä ,  Jani Vuorenpää

    IPC分类号： C08J510

    CPC分类号： C08L3/06 ,  A61K9/282 ,  A61K9/284 ,  A61K9/286 ,  C08J3/03 ,  C08L97/02 ,  C08L2666/02

    摘要： The invention relates to a hydrophobic polymer dispersion and a solvent-free process for the preparation thereof. According to the invention, the dispersion contains starch ester together with dispersion admixtures known as such. According to the process, the polymer is first mixed with a plasticizer in order to obtain a plasticized polymer blend. The plasticized polymer blend is then mixed with dispersion admixtures and water at an elevated temperature so as to form a dispersion. The plasticizing of the polymer and the dispersion of the mixture in water can be performed in an extruder. The obtained dispersion is homogenized in order to improve its stability. The dispersion obtained by the invention can be used to coat paper or board, as a primer or a component in paint or labeling adhesives, and it is also suitable for the production of cast films and as a binder in materials based on cellulose fibers, as well as for coating medicinal preparations.

    摘要翻译： 本发明涉及疏水性聚合物分散体和无溶剂的制备方法。 根据本发明，分散体含有淀粉酯以及已知的分散混合物。 根据该方法，首先将聚合物与增塑剂混合以获得增塑的聚合物共混物。 然后将增塑的聚合物共混物在高温下与分散体混合物和水混合，以形成分散体。 聚合物的增塑和混合物在水中的分散体可以在挤出机中进行。 将得到的分散体均质化以提高其稳定性。 通过本发明得到的分散体可用于涂布纸或纸板，作为涂料或标签粘合剂中的底漆或组分，并且还适用于在基于纤维素纤维的材料中生产流延膜和粘合剂，如 以及用于涂药剂。

    Composition for pH dependent controlled release of active ingredients and methods for producing it
    3.
    发明授权
    Composition for pH dependent controlled release of active ingredients and methods for producing it 失效
    用于pH依赖性控制释放活性成分的组合物及其生产方法

    公开(公告)号：US5656292A

    公开(公告)日：1997-08-12

    申请号：US498341

    申请日：1995-07-05

    申请人： Arto Olavi Urtti ,  Soili Hellevi Peltonen ,  Timo Petteri Paronen ,  Leena Johanna Nakari ,  Jani-Emanuel Vuorenpaa

    发明人： Arto Olavi Urtti ,  Soili Hellevi Peltonen ,  Timo Petteri Paronen ,  Leena Johanna Nakari ,  Jani-Emanuel Vuorenpaa

    IPC分类号： A61K9/22 ,  A61K9/20 ,  A61K47/36 ,  C08B31/04 ,  A61K9/24 ,  A61K9/26 ,  C08B31/02

    CPC分类号： A61K9/2059 ,  C08B31/04

    摘要： The present invention is related to a composition for pH dependent or pH regulated controlled release of active ingredients especially drugs. The composition consists of a compactible mixture of the active ingredient and starch molecules substituted with acetate and dicarboxylate residues. The preferred dicarboxylate acid is succinate. The average substitution degree of the acetate residue is at least 1 and 0.2-1.2 for the dicarboxylate residue. The starch molecules can have the acetate and dicarboxylate residues attached to the same starch molecule backbone or attached to separate starch molecule backbones. The present invention also discloses methods for preparing said starch acetate dicarboxylates by transesterification or mixing of starch acetates and starch dicarboxylates respectively.

    摘要翻译： 本发明涉及用于pH依赖性或pH调节的活性成分（特别是药物）的控制释放的组合物。 该组合物由活性成分和用乙酸酯和二羧酸酯残基取代的淀粉分子的可压缩混合物组成。 优选的二羧酸是琥珀酸盐。 对于二羧酸酯残基，乙酸酯残基的平均取代度为至少1和0.2-1.2。 淀粉分子可以使乙酸酯和二羧酸酯残基连接到相同的淀粉分子骨架上或连接到分离的淀粉分子骨架上。 本发明还公开了分别通过酯交换或混合淀粉乙酸酯和淀粉二羧酸盐来制备所述乙酸淀粉二羧酸淀粉的方法。