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    Process For Removing Water From Aqueous Solutions Of Proteins
    4.
    发明申请
    Process For Removing Water From Aqueous Solutions Of Proteins 有权
    从蛋白质水溶液中去除水的方法

    公开(公告)号：US20080021204A1

    公开(公告)日：2008-01-24

    申请号：US10590095

    申请日：2005-02-18

    Applicant: Felipe Donate ,  Timothy Frank ,  Barbara Grabowski

    Inventor： Felipe Donate ,  Timothy Frank ,  Barbara Grabowski

    IPC: C07K1/00

    CPC classification number: C07K1/145

    Abstract: A method for extracting water from an aqueous solution of a protein comprising the steps of: (a) intermixing the aqueous solution of the protein with a sufficient quantity of at least one glycol ether at a temperature at least 30 centigrade degrees above the lower critical solution temperature (LCST), preferably at least 20 centigrade degrees above the LCST, and most preferably at least 10 degrees above the LCST, to form a suspension comprising a concentrated aqueous protein phase and a liquid organic phase comprising said at least one glycol ether and at least 10 percent water extracted from the aqueous solution of the protein, wherein the glycol ether has an inverse solubility in water, with the proviso that the solubility of the glycol ether in water is significantly less than the solubility of water in the glycol ether, and the glycol ether does not significantly deactivate the protein, and (b) separating the concentrated aqueous protein phase formed in step (a) from at least a portion of the liquid organic phase.

    Abstract translation: 一种从蛋白质水溶液中提取水的方法，包括以下步骤：（a）将蛋白质水溶液与足够量的至少一种二醇醚在比较低临界溶液高至少30摄氏度的温度下混合 温度（LCST），优选高于LCST至少20摄氏度，最优选高于LCST至少10度，以形成包含浓缩的蛋白质水相和包含所述至少一种二醇醚的液体有机相的悬浮液，并且在 从蛋白质水溶液中提取的最少10％的水，其中乙二醇醚在水中具有相反的溶解度，条件是二醇醚在水中的溶解度显着小于水在乙二醇醚中的溶解度，以及 乙二醇醚不会使蛋白质显着失活，和（b）将步骤（a）中形成的浓缩水性蛋白质相从至少一个孔 液体有机相。

    Medical instrument
    5.
    发明申请
    Medical instrument 失效
    医疗仪器

    公开(公告)号：US20050033355A1

    公开(公告)日：2005-02-10

    申请号：US10848800

    申请日：2004-05-19

    Applicant: Timothy Frank ,  Alfred Cuschieri ,  Duncan Martin ,  James Gove

    Inventor： Timothy Frank ,  Alfred Cuschieri ,  Duncan Martin ,  James Gove

    IPC: A61B17/00 ,  A61B17/28

    CPC classification number: A61B17/2909 ,  A61B2017/00265 ,  A61B2017/0046 ,  A61B2017/00469 ,  A61B2017/291 ,  A61B2017/2923

    Abstract: The invention relates to a medical instrument, in particular an endoscopic instrument, with an instrument shaft, a tool positioned on the distal end of the instrument shaft, and a handle, which can be secured on the instrument shaft so that it can be moved in an axial extension of the instrument shaft. In order to create an instrument which makes possible a comfortable, safe, and reliable handling even with the most varied application purposes, it is proposed with the invention that the handle can be secured on the instrument shaft so that it can be moved by at least one degree of freedom with respect to the instrument shaft.

    Abstract translation: 本发明涉及一种医疗仪器，特别是内窥镜器械，其具有仪器轴，位于仪器轴的远端上的工具和手柄，其能够固定在仪器轴上，使得其可以移动 仪器轴的轴向延伸。 为了创建一种使得即使具有最多样的应用目的也能舒适，安全和可靠的处理的仪器，本发明提出了可以将手柄固定在仪器轴上，使得其可以至少移动至少 相对于仪器轴的一个自由度。

    Enzymatic resolution of propylene glycol alkyl (or aryl) ethers and ether acetates
    6.
    发明申请
    Enzymatic resolution of propylene glycol alkyl (or aryl) ethers and ether acetates 失效
    丙二醇烷基（或芳基）醚和乙醚乙酸酯的酶解

    公开(公告)号：US20050026260A1

    公开(公告)日：2005-02-03

    申请号：US10502692

    申请日：2003-03-21

    Applicant: Sol Resnick ,  Felipe Donate ,  Timothy Frank ,  Thomas Thyne ,  Paul Foley

    Inventor： Sol Resnick ,  Felipe Donate ,  Timothy Frank ,  Thomas Thyne ,  Paul Foley

    IPC: C12P7/18 ,  C12P41/00

    CPC classification number: C12P7/18 ,  C12P41/004

    Abstract: Glycol ether acetates, and in particular propylene glycol alkyl (or aryl) ether acetates, can be resolved enzymatically by enantioselective hydrolysis with a hydrolase at high concentrations of substrates; in some embodiments, the hydrolase is a lipase. Glycol ethers, and in particular propylene glycol alkyl (or aryl) ethers, can be resolved enzymatically by enantioselective transesterification with a hydrolase, in the presence of an acyl donor, at high concentrations of substrates; in some embodiments, the hydrolase is a lipase.

    Abstract translation: 乙二醇醚乙酸酯，特别是丙二醇烷基（或芳基）醚乙酸酯可以通过在高浓度底物下用水解酶进行对映选择性水解来酶解; 在一些实施方案中，水解酶是脂肪酶。 乙二醇醚，特别是丙二醇烷基（或芳基）醚可以通过在酰基供体存在下，在高浓度底物下用水解酶进行对映选择性酯交换酶解解; 在一些实施方案中，水解酶是脂肪酶。

    Device for supporting at least one arm of an operating person during a surgical operation
    7.
    发明申请
    Device for supporting at least one arm of an operating person during a surgical operation 失效
    用于在外科手术期间支撑操作者的至少一个臂的装置

    公开(公告)号：US20050015879A1

    公开(公告)日：2005-01-27

    申请号：US10866969

    申请日：2004-06-14

    Applicant: Alfred Cuschieri ,  Timothy Frank ,  Ian Rutherford ,  Donald McLean ,  Stuart Brown

    Inventor： Alfred Cuschieri ,  Timothy Frank ,  Ian Rutherford ,  Donald McLean ,  Stuart Brown

    IPC: A61B19/00 ,  A61G13/12

    CPC classification number: A61B90/60

    Abstract: A device for supporting at least one arm of an operating person during a surgical or medical operation comprises at least one supporting element for supporting the at least one arm of the operating person, the supporting element being arranged at a carrying structure for carrying the at least one supporting element. The carrying structure is configured such that the at least one supporting element can be lowered or raised for adjusting the height of the operating person's arm. The carrying structure comprises a control mechanism for lowering or raising the at least one supporting element, wherein the control mechanism includes a force load switch for activating the lowering or raising of the at least one supporting element, wherein the force load switch activates the lowering or raising of the at least one supporting element upon detecting compressive and/or tensile forces or motions acting via the at least one supporting element on the force load switch.

    Abstract translation: 用于在手术或医疗操作期间支撑操作人员的至少一个臂的装置包括用于支撑操作者的至少一个臂的至少一个支撑元件，所述支撑元件布置在用于承载至少 一个支撑元素 承载结构构造成使得可以降低或升高至少一个支撑元件以调节操作者的手臂的高度。 所述承载结构包括用于降低或升高所述至少一个支撑元件的控制机构，其中所述控制机构包括用于启动所述至少一个支撑元件的下降或升高的力负载开关，其中所述力负载开关启动所述下降或 在检测到通过力负载开关上的至少一个支撑元件作用的压缩和/或拉力或运动时，升高至少一个支撑元件。

    Steering wheel control device with integral legs
    9.
    发明授权
    Steering wheel control device with integral legs 有权

    公开(公告)号：US11179629B1

    公开(公告)日：2021-11-23

    申请号：US16926783

    申请日：2020-07-13

    Applicant: Timothy Frank Bernasch ,  Ahmed Abdullahi Omar

    Inventor： Timothy Frank Bernasch ,  Ahmed Abdullahi Omar

    IPC: A63F13/245 ,  A63F13/803

    Abstract: Embodiments of the present invention provide a device and a method of supporting a game controller such as a steering wheel without mounting it to a structure such as a desk or table. The game controller is instead supported on a number of extendable legs which are integral to the controller. In specific embodiments, a game controller with integral legs comprises a base which includes three telescoping legs which move outwardly to the extended position for providing support on the floor in front on the user's seat.

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