公开(公告)号：US20060188519A1

公开(公告)日：2006-08-24

申请号：US11152520

申请日：2005-06-13

Applicant: To Cheung ,  Mun Au ,  Wing Lo ,  Ka To ,  Chui Chow ,  Tsz Tracy Tam ,  Chun Wu

Inventor： To Cheung ,  Mun Au ,  Wing Lo ,  Ka To ,  Chui Chow ,  Tsz Tracy Tam ,  Chun Wu

IPC: A61K39/21 ,  A61K39/12

CPC classification number: C07K14/005 ,  C12N2770/20022 ,  G01N33/56983

Abstract: The present invention discloses 27 immunoreactive peptides and antibodies immunologically reactive with said peptides. Such peptides and antibodies can be used for diagnosis of SARS-CoV infection as well as for preparing vaccination against SARS-CoV or a closely related coronaviruses.

Abstract translation: 本发明公开了27种与所述肽免疫反应性的免疫反应肽和抗体。 这些肽和抗体可用于SARS-CoV感染的诊断以及用于准备针对SARS-CoV或密切相关的冠状病毒的疫苗接种。

公开(公告)号：US20050135974A1

公开(公告)日：2005-06-23

申请号：US10739784

申请日：2003-12-18

Applicant: Michael Harvey ,  Lara Dowland ,  Breck Parker ,  Stephen Sherman ,  To Cheung ,  Bin Li ,  Yong Peng ,  Qi- Cai ,  Ke Liu ,  Hai Ge ,  Fu Deng ,  Li Ding

Inventor： Michael Harvey ,  Lara Dowland ,  Breck Parker ,  Stephen Sherman ,  To Cheung ,  Bin Li ,  Yong Peng ,  Qi- Cai ,  Ke Liu ,  Hai Ge ,  Fu Deng ,  Li Ding

IPC: B01L3/00 ,  B01L9/00 ,  G01N1/31 ,  G01N31/22

CPC classification number: B01L3/50855 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/0822 ,  B01L2300/0829 ,  G01N1/312

Abstract: The present invention relates to a device for preparing assay samples using a number of microscope slides. Each slide has a number of assay reaction surface locations spaced on the planar surface of the slide. In preferred embodiments, the device comprises, in part, a microscope slide holder that has the exterior dimensions of a SBS standard microplate, such as a 96 well plate. The device accepts conventional microscope slides equipped with sixteen microarray surfaces spaced nine millimeters apart on center, or four for a 96 well plate. Individual chamber plates are placed on top of the slides, creating an individual well above each assay reaction surface location. In preferred embodiments, each assay reaction surface location can comprise a microarray of multiple reactive sites. Thus, parallel processing can be done of samples for genomic or proteomic profiling. An advantage of the present invention is that one can use the conventional high throughput assaying equipment for SBS standard microplates while using conventional microscope slides, thereby allowing the use of robotic assay reading equipment designed for slides.

Abstract translation: 本发明涉及使用多个显微镜幻灯片制备测定样品的装置。 每个载片具有在载玻片平面上间隔开的多个测定反应表面位置。 在优选实施例中，该装置部分地包括具有诸如96孔板的SBS标准微板的外部尺寸的显微镜载玻片保持器。 该装置接受传统的显微镜载玻片，其中装有十六个微阵列表面，中心隔开9毫米，或四个96孔板。 单独的室板放置在载玻片的顶部，在每个测定反应表面位置之上产生单个孔。 在优选实施方案中，每个测定反应表面位置可以包含多个反应性位点的微阵列。 因此，可以对基因组或蛋白质组图谱的样品进行并行处理。 本发明的一个优点是可以使用传统的高通量测定设备用于SBS标准微孔板，同时使用传统的显微镜载玻片，从而允许使用为幻灯片设计的机器人测定读数设备。

公开(公告)号：US07867372B2

公开(公告)日：2011-01-11

申请号：US12065608

申请日：2006-09-28

Applicant: To Cheung ,  Long Yin Zhu ,  Yan Li

Inventor： To Cheung ,  Long Yin Zhu ,  Yan Li

IPC: G01N27/447 ,  G01N27/26

CPC classification number: G01N27/44704

Abstract: An apparatus for performing vertical electrophoresis comprises a main body, a pair of gel plates, a pair of clamping devices, and a lower buffer tank. The clamping devices are slidably attachable to the sides of the main body between a loading position for allowing the gel plates to be inserted into the main body, and a locking position for allowing secure attachment of the gel plates to the main body by a single horizontal sliding movement.

Abstract translation: 用于执行垂直电泳的装置包括主体，一对凝胶板，一对夹紧装置和下缓冲罐。 夹持装置可滑动地附接到主体的侧面，用于允许凝胶板插入主体的装载位置和用于允许凝胶板通过单个水平面牢固地附接到主体的锁定位置 滑动运动。

公开(公告)号：US20080202935A1

公开(公告)日：2008-08-28

申请号：US12065608

申请日：2006-09-28

Applicant: To Cheung ,  Long Yin Zhu ,  Yan Li

Inventor： To Cheung ,  Long Yin Zhu ,  Yan Li

IPC: B01D57/02

CPC classification number: G01N27/44704

Abstract: An apparatus for performing vertical electrophoresis comprises a main body, a pair of gel plates, a pair of clamping devices, and a lower buffer tank. The clamping devices are slidably attachable to the sides of the main body between a loading position for allowing the gel plates to be inserted into the main body, and a locking position for allowing secure attachment of the gel plates to the main body by a single horizontal sliding movement.

Abstract translation: 用于执行垂直电泳的装置包括主体，一对凝胶板，一对夹紧装置和下缓冲罐。 夹持装置可滑动地附接到主体的侧面，用于允许凝胶板插入主体的装载位置和用于允许凝胶板通过单个水平面牢固地附接到主体的锁定位置 滑动运动。

公开(公告)号：US08679809B2

公开(公告)日：2014-03-25

申请号：US11750863

申请日：2007-05-18

Applicant: Barbara Pui Chan ,  Godfrey Chi-Fung Chan ,  Hoi Ling Wong ,  Pik To Cheung ,  Song-Eng Kathryn Cheah ,  Danny Chan

Inventor： Barbara Pui Chan ,  Godfrey Chi-Fung Chan ,  Hoi Ling Wong ,  Pik To Cheung ,  Song-Eng Kathryn Cheah ,  Danny Chan

IPC: C12N11/04

CPC classification number: C12N5/0602 ,  A61K35/12 ,  C12M25/14 ,  C12N5/0012 ,  C12N5/0655 ,  C12N5/0663 ,  C12N2510/02 ,  C12N2533/54 ,  C12N2533/90

Abstract: A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.

Abstract translation: 已经开发了一种方法来生产具有高达100％包封效率和高细胞活力的稳定的细胞基质微球，使用具有差的形状和机械稳定性的基质或生物材料体系，包括通过显微注射或手术植入的细胞治疗剂，3D培养物 使用酶消化或机械解离并且用于增强治疗性生物分子的产生的体外扩增而不重复细胞分裂，以及用于形态发生研究的体外模拟。 改进的液滴生成方法简单可伸缩，当使用的基质或生物材料系统具有低浓度，缓慢的相变，形状和机械稳定性差时，能够生产细胞基质微球。