公开(公告)号：US20140128799A1

公开(公告)日：2014-05-08

申请号：US14126929

申请日：2012-06-20

申请人： Tohru Tanaka ,  Katsushi Inoue ,  Takuya Ishii ,  Tokato Yoshida

发明人： Tohru Tanaka ,  Katsushi Inoue ,  Takuya Ishii ,  Tokato Yoshida

IPC分类号： A61N5/06 ,  A61K41/00

CPC分类号： A61N5/062 ,  A61K31/197 ,  A61K41/0061 ,  A61K41/0071 ,  A61K49/0052

摘要： It is to provide photodynamic therapy (PDT) and photodynamic diagnosis (PDD) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing PDT and PDD targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin IX, etc.) or ALAs such as 5-aminolevulinic acid (ALA), ALA methyl ester, ALA ethyl ester, ALA propyl ester, ALA butyl ester, ALA pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm.

摘要翻译： 它是提供光动力疗法（PDT）和光动力学诊断（PDD），适用于诊断和治疗需要一定程度深度穿透的部位，如皮下癌和由血管和脂肪包围的淋巴结。 通过施用包含光敏剂如四吡咯基化合物（光调节素，原卟啉IX等）或ALA的组合物，例如5-氨基乙酰丙酸（ALA），ALA甲酯， ALA乙酯，ALA丙酯，ALA丁酯，ALA戊酯或其盐酸盐，磷酸盐或硫酸盐，然后用波长480〜580nm的激发光照射。