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    B. braunii, race B gene for a triterpene methyltransferase enzyme and uses thereof
    2.
    发明授权
    B. braunii, race B gene for a triterpene methyltransferase enzyme and uses thereof 有权

    公开(公告)号：US08487158B2

    公开(公告)日：2013-07-16

    申请号：US12489038

    申请日：2009-06-22

    申请人： Joseph Chappell ,  Shigeru Okada ,  Scott Kinison ,  Tom Niehaus

    发明人： Joseph Chappell ,  Shigeru Okada ,  Scott Kinison ,  Tom Niehaus

    IPC分类号： C12N15/29 ,  C12N15/52 ,  C12N15/82

    摘要： Provided is an isolated polypeptide having triterpene methyltransferase activity. Also provided is an isolated nucleic acid molecule that encodes the triterpene methyltransferase polypeptides; a vector comprising the nucleic acid molecules that encode the triterpene methyltransferase polypeptides; and a host cell(s) transfected with the aforementioned nucleic acid molecule or vector. In another aspect, a method of producing a methylated triterpene is provided. The method comprises providing a metabolizable carbon source to a host cell transfected with a nucleic acid molecule that encodes a triterpene methyltransferase under conditions sufficient for production of a methylated triterpene. The method optionally further comprises isolating the methylated triterpene produced by the host cell.

    Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use
    3.
    发明授权
    Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use 有权
    Botryoccocus braunii三萜合酶蛋白和核酸分子及其使用方法

    公开(公告)号：US07985568B2

    公开(公告)日：2011-07-26

    申请号：US12539442

    申请日：2009-08-11

    申请人： Joe Chappell ,  Shigeru Okada ,  Tom Niehaus ,  Tim Devarenne

    发明人： Joe Chappell ,  Shigeru Okada ,  Tom Niehaus ,  Tim Devarenne

    IPC分类号： C12P5/00

    CPC分类号： C12P5/007 ,  C12N9/1085

    摘要： This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules, transformed hosts and encoded proteins to produce high levels of triterpene hydrocarbons.

    摘要翻译： 本申请涉及编码三萜合酶，特别是山梨酸合成酶的核酸分子的功能鉴定和表征。 还描述了包含本发明的核酸分子，由核酸分子编码的蛋白质和使用核酸分子，转化宿主和编码蛋白质以产生高水平三萜烷烃的方法的宿主细胞。

    B. BRAUNII, RACE B GENE FOR A TRITERPENE METHYLTRANSFERASE ENZYME AND USES THEREOF
    4.
    发明申请
    B. BRAUNII, RACE B GENE FOR A TRITERPENE METHYLTRANSFERASE ENZYME AND USES THEREOF 有权
    B.BRAUNII，RACE B基因的三磷酸甲酯衍生物酶及其用途

    公开(公告)号：US20100009423A1

    公开(公告)日：2010-01-14

    申请号：US12489038

    申请日：2009-06-22

    申请人： Joseph Chappell ,  Shigeru Okada ,  Scott Kinison ,  Tom Niehaus

    发明人： Joseph Chappell ,  Shigeru Okada ,  Scott Kinison ,  Tom Niehaus

    IPC分类号： C12P5/02 ,  C12N9/10 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21 ,  C12N1/15 ,  C12N5/04 ,  C12N5/06 ,  C12N1/12

    CPC分类号： C12N9/1007 ,  C12N15/8243 ,  C12P5/007 ,  C12Y201/01

    摘要： Provided is an isolated polypeptide having triterpene methyltransferase activity. Also provided is an isolated nucleic acid molecule that encodes the triterpene methyltransferase polypeptides; a vector comprising the nucleic acid molecules that encode the triterpene methyltransferase polypeptides; and a host cell(s) transfected with the aforementioned nucleic acid molecule or vector. In another aspect, a method of producing a methylated triterpene is provided. The method comprises providing a metabolizable carbon source to a host cell transfected with a nucleic acid molecule that encodes a triterpene methyltransferase under conditions sufficient for production of a methylated triterpene. The method optionally further comprises isolating the methylated triterpene produced by the host cell.

    摘要翻译： 提供了具有三萜甲基转移酶活性的分离的多肽。 还提供了编码三萜甲基转移酶多肽的分离的核酸分子; 包含编码三萜甲基转移酶多肽的核酸分子的载体; 和用上述核酸分子或载体转染的宿主细胞。 另一方面，提供了生产甲基化三萜的方法。 该方法包括向在用于生产甲基化三萜烯的条件下编码三萜甲基转移酶的核酸分子转染的宿主细胞提供可代谢碳源。 所述方法任选进一步包括分离由宿主细胞产生的甲基化三萜烯。

    B. braunii, race B gene for a triterpene methyltransferase enzyme and uses thereof
    5.
    发明授权
    B. braunii, race B gene for a triterpene methyltransferase enzyme and uses thereof 有权
    B. braunii，用于三萜甲基转移酶的种族B基因及其用途

    公开(公告)号：US08704040B2

    公开(公告)日：2014-04-22

    申请号：US12489038

    申请日：2009-06-22

    申请人： Joseph Chappell ,  Shigeru Okada ,  Scott Kinison ,  Tom Niehaus

    发明人： Joseph Chappell ,  Shigeru Okada ,  Scott Kinison ,  Tom Niehaus

    IPC分类号： C12N15/29 ,  C12N15/52 ,  C12N15/82

    CPC分类号： C12N9/1007 ,  C12N15/8243 ,  C12P5/007 ,  C12Y201/01

    摘要： Provided is an isolated polypeptide having triterpene methyltransferase activity. Also provided is an isolated nucleic acid molecule that encodes the triterpene methyltransferase polypeptides; a vector comprising the nucleic acid molecules that encode the triterpene methyltransferase polypeptides; and a host cell(s) transfected with the aforementioned nucleic acid molecule or vector. In another aspect, a method of producing a methylated triterpene is provided. The method comprises providing a metabolizable carbon source to a host cell transfected with a nucleic acid molecule that encodes a triterpene methyltransferase under conditions sufficient for production of a methylated triterpene. The method optionally further comprises isolating the methylated triterpene produced by the host cell.

    摘要翻译： 提供了具有三萜甲基转移酶活性的分离的多肽。 还提供了编码三萜甲基转移酶多肽的分离的核酸分子; 包含编码三萜甲基转移酶多肽的核酸分子的载体; 和用上述核酸分子或载体转染的宿主细胞。 另一方面，提供了生产甲基化三萜的方法。 该方法包括向在用于生产甲基化三萜烯的条件下编码三萜甲基转移酶的核酸分子转染的宿主细胞提供可代谢碳源。 所述方法任选进一步包括分离由宿主细胞产生的甲基化三萜烯。

    Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use
    6.
    发明授权
    Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use 有权
    Botryoccocus braunii三萜合酶蛋白和核酸分子及其使用方法

    公开(公告)号：US08592180B2

    公开(公告)日：2013-11-26

    申请号：US13186185

    申请日：2011-07-19

    申请人： Joe Chappell ,  Shigeru Okada ,  Tom Niehaus ,  Tim Devarenne

    发明人： Joe Chappell ,  Shigeru Okada ,  Tom Niehaus ,  Tim Devarenne

    IPC分类号： C12P21/06

    CPC分类号： C12P5/007 ,  C12N9/1085

    摘要： This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules, transformed hosts and encoded proteins to produce high levels of triterpene hydrocarbons.

    摘要翻译： 本申请涉及编码三萜合酶，特别是山梨酸合成酶的核酸分子的功能鉴定和表征。 还描述了包含本发明的核酸分子，由核酸分子编码的蛋白质和使用核酸分子，转化宿主和编码蛋白质以产生高水平三萜烷烃的方法的宿主细胞。