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1.发明申请3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same 失效3-羟基-3-（2-噻吩基）丙酰胺及其制备方法和使用其的3-氨基-1-（2-噻吩基）-1-丙醇的制备方法公开(公告)号：US20050107621A1
公开(公告)日：2005-05-19
申请号：US10944055
申请日：2004-09-20
申请人： Jun Takehara , Jingping Qu , Kazuaki Kanno , Hiroshi Kawabata , Yasumasa Dekishima , Makoto Ueda , Kyoko Endo , Takeshi Murakami , Tomoko Sasaki , Hisatoshi Uehara , Youichi Matsumoto , Shihomi Suzuki
发明人： Jun Takehara , Jingping Qu , Kazuaki Kanno , Hiroshi Kawabata , Yasumasa Dekishima , Makoto Ueda , Kyoko Endo , Takeshi Murakami , Tomoko Sasaki , Hisatoshi Uehara , Youichi Matsumoto , Shihomi Suzuki
IPC分类号： A61K31/381 , C07D333/16 , C07D333/22
CPC分类号： C07D333/16 , B01J31/1805 , B01J31/2295 , B01J2231/643 , B01J2531/80 , B01J2531/821
摘要： The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost. According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a β-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group. (each of the substituents is as described in claim 1).
摘要翻译： 本发明的目的是提供可用作药物制剂等的合成中间体的3-羟基-3-（2-噻吩基）丙酰胺和获得光学活性3-氨基-1-（2-噻吩基） 使用相同的1-丙醇，反应产率高，光学收率高，工业成本低。 根据本发明，3-氨基-1-（2-噻吩基）-1-丙醇通过在由组合的化合物构成的催化剂存在下进行具有噻吩环的β-酮羰基化合物的不对称还原而得到 VIII或IX族金属（例如钌化合物）和由特定光学活性二胺衍生物（例如二苯基乙二胺衍生物）表示的不对称配体，或使用电池，所述电池等的处理产物 微生物，根据需要，进行酯基的酰胺化，然后进行酰胺基的还原。 （每个取代基如权利要求1所述）。
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2.发明授权3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same 失效3-羟基-3-（2-噻吩基）丙酰胺及其制备方法和使用其的3-氨基-1-（2-噻吩基）-1-丙醇的制备方法公开(公告)号：US07659409B2
公开(公告)日：2010-02-09
申请号：US10944055
申请日：2004-09-20
申请人： Jun Takehara , Jingping Qu , Kazuaki Kanno , Hiroshi Kawabata , Yasumasa Dekishima , Makoto Ueda , Kyoko Endo , Takeshi Murakami , Tomoko Sasaki , Hisatoshi Uehara , Youichi Matsumoto , Shihomi Suzuki
发明人： Jun Takehara , Jingping Qu , Kazuaki Kanno , Hiroshi Kawabata , Yasumasa Dekishima , Makoto Ueda , Kyoko Endo , Takeshi Murakami , Tomoko Sasaki , Hisatoshi Uehara , Youichi Matsumoto , Shihomi Suzuki
IPC分类号： C07D333/22
CPC分类号： C07D333/16 , B01J31/1805 , B01J31/2295 , B01J2231/643 , B01J2531/80 , B01J2531/821
摘要： The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost.According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a β-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group. (each of the substituents is as described in claim 1).
摘要翻译： 本发明的目的是提供可用作药物制剂等的合成中间体的3-羟基-3-（2-噻吩基）丙酰胺和获得光学活性3-氨基-1-（2-噻吩基） 使用相同的1-丙醇，反应产率高，光学收率高，工业成本低。 根据本发明，3-氨基-1-（2-噻吩基）-1-丙醇通过在由组合的化合物构成的催化剂存在下进行具有噻吩环的β-酮羰基化合物的不对称还原而得到 VIII或IX族金属（例如钌化合物）和由特定光学活性二胺衍生物（例如二苯基乙二胺衍生物）表示的不对称配体，或使用电池，所述电池等的处理产物 微生物，根据需要，进行酯基的酰胺化，然后进行酰胺基的还原。 （每个取代基如权利要求1所述）。
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3.发明授权
公开(公告)号：US4981767A
公开(公告)日：1991-01-01
申请号：US371802
申请日：1989-06-27
申请人： Yoshinori Tokura , Shinichi Suzuki , Junko Gouda , Hideo Toda , Akira Itsubo , Tomoko Sasaki
发明人： Yoshinori Tokura , Shinichi Suzuki , Junko Gouda , Hideo Toda , Akira Itsubo , Tomoko Sasaki
CPC分类号： G03G5/0696 , C09B67/0035
摘要： A photoconductive material comprising a mixed crystal of at least two phthalocyanine compounds whose central substances are different from each other, the phthalocyanine compounds being represented by formula (I): ##STR1## wherein A represents a substance capable of bonding to the phthalocyanine ligand through a covalent bond or a coordinate bond. The photoconductive material exhibits stability to heat and light and sufficient sensitivity in the visible to near infrared region.
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公开(公告)号：US4914548A
公开(公告)日：1990-04-03
申请号：US191339
申请日：1988-05-09
申请人： Yoshiyo Kubo , Tetsushi Tamura , Tomoko Sasaki
发明人： Yoshiyo Kubo , Tetsushi Tamura , Tomoko Sasaki
IPC分类号： H01G9/02
CPC分类号： H01G9/02
摘要： An electrolytic paper for an electrolytic capacitor interposed between an anode foil and a cathode foil is made of cellulose fiber induced with organic substituent. The inducing reaction of the organic substituent is selected from etherification for hydroxyl group contained in the cellulose fiber, esterification for hydroxyl group contained in the cellulose fiber, or acetalization for hydroxyl group contained in the cellulose fiber. The swelling degree of the electrolytic paper made of this organic substituent induced fiber for electrolyte is increased.
摘要翻译： 介于阳极箔和阴极箔之间的用于电解电容器的电解纸由用有机取代基诱导的纤维素纤维制成。 有机取代基的诱导反应选自纤维素纤维中含有的羟基的醚化，纤维素纤维中所含的羟基的酯化，或纤维素纤维中所含的羟基的缩醛化。 由该有机取代基诱导的电解纤维制成的电解纸的溶胀度增加。
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公开(公告)号：US20110274642A1
公开(公告)日：2011-11-10
申请号：US13144279
申请日：2009-12-24
申请人： Satoshi Yamaki , Tomoko Sasaki
发明人： Satoshi Yamaki , Tomoko Sasaki
摘要： The present invention provides a hair cosmetic composition containing the following ingredients (1) to (4): (1) petrolatum in an amount of 0.01 to 20 mass % with respect to the cosmetic composition; (2) a hydroxyalkylurea in an amount of 0.001 to 30 mass % with respect to the cosmetic composition; (3) a tertiary amine cationic surfactant and/or a quaternary ammonium salt cationic surfactant in an amount of 0.1 to 10 mass % with respect to the cosmetic composition; and (4) water. The hair cosmetic composition can finish the hair, after shampooing, with excellent smoothness, suppleness, and moistness and which is suitable for use as a rinse, a conditioner, etc.
摘要翻译： 本发明提供一种含有以下成分（1）〜（4）的化妆品组合物：（1）相对于化妆品组合物为0.01〜20质量％的凡士林; （2）相对于化妆品组合物为0.001〜30质量％的羟烷基脲; （3）相对于化妆品组合物为0.1〜10质量％的叔胺阳离子表面活性剂和/或季铵盐阳离子表面活性剂; 和（4）水。 头发美容组合物可以在洗发后完成头发，具有优异的光滑度，柔软性和湿润性，并且适合用作冲洗剂，护发素等。
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公开(公告)号：US20100105890A1
公开(公告)日：2010-04-29
申请号：US12517900
申请日：2007-12-07
IPC分类号： C07H1/00
摘要： An object of the present invention is to provide a industrially appropriate method for producing the β-anomers of ribofuranose derivatives in a highly selective manner at a high yield. The present invention provides a method for producing ribofuranose derivatives wherein β-anomers is precipitated from among the generated furanose derivatives by controlling the amount of a reaction reagent used and/or using a poor solvent in the acetolysis reactions of 2,3,5-tri-O-acyl-1-O-alkyl-ribofuranose and 2,3-di-O-acyl-1-O-alkyl-5-deoxy-ribofuranose.
摘要翻译： 本发明的目的是提供以高产率以高度选择性的方式制备呋喃核糖衍生物的一种工业上合适的方法。 本发明提供一种制备呋喃核糖衍生物的方法，其中通过控制2,3,5-三氟乙酸的乙酰溶解反应中使用的反应试剂和/或使用不良溶剂的量，从生成的呋喃糖衍生物中沉淀出α- 三-O-酰基-1-O-烷基 - 呋喃核糖和2,3-二-O-酰基-1-O-烷基-5-脱氧 - 呋喃核糖。
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公开(公告)号：US06900298B2
公开(公告)日：2005-05-31
申请号：US10361593
申请日：2003-02-11
申请人： Yuki Takuma , Kyoko Endo , Takeshi Murakami , Tomoko Maeda , Tomoko Sasaki , Youichi Matsumoto
发明人： Yuki Takuma , Kyoko Endo , Takeshi Murakami , Tomoko Maeda , Tomoko Sasaki , Youichi Matsumoto
IPC分类号： C07H19/044 , C07H19/052 , C07H19/056 , C07H19/06 , C07H1/00
CPC分类号： C07H19/06 , C07H19/044 , C07H19/052 , C07H19/056
摘要： A process for efficiently producing a nucleic acid derivative by condensing a specific nitrogen-containing heterocyclic compound such as a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose using a less expensive and safe reagent. Namely, a process for producing a nucleic acid derivative by condensing a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose in the presence of an iron halide.
摘要翻译： 通过使用较便宜且安全的试剂将具体的含氮杂环化合物如二氮6元杂环化合物或三氮杂五元杂环化合物与戊糖缩合而有效地制备核酸衍生物的方法。 即，在卤化铁存在下，通过将二氮6元杂环化合物或三氮杂五元杂环化合物与戊糖缩合而制造核酸衍生物的方法。
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公开(公告)号：US08394935B2
公开(公告)日：2013-03-12
申请号：US12517900
申请日：2007-12-07
摘要： An object of the present invention is to provide a industrially appropriate method for producing the β-anomers of ribofuranose derivatives in a highly selective manner at a high yield. The present invention provides a method for producing ribofuranose derivatives wherein β-anomers is precipitated from among the generated furanose derivatives by controlling the amount of a reaction reagent used and/or using a poor solvent in the acetolysis reactions of 2,3,5-tri-O-acyl-1-O-alkyl-ribofuranose and 2,3-di-O-acyl-1-O-alkyl-5-deoxy-ribofuranose.
摘要翻译： 本发明的目的是提供以高产率以高度选择性的方式制备呋喃核糖衍生物的一种工业上合适的方法。 本发明提供一种制备呋喃核糖衍生物的方法，其中通过控制2,3,5-三氟乙酸的乙酰溶解反应中使用的反应试剂和/或使用不良溶剂的量，从生成的呋喃糖衍生物中沉淀出α- 三-O-酰基-1-O-烷基 - 呋喃核糖和2,3-二-O-酰基-1-O-烷基-5-脱氧 - 呋喃核糖。
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