公开(公告)号：US20120052592A9

公开(公告)日：2012-03-01

申请号：US12532245

申请日：2008-03-27

申请人： Tsuyoshi Maekawa ,  Tomonori Izumi ,  Yasutaka Oda ,  Yuki Akiyoshi

发明人： Tsuyoshi Maekawa ,  Tomonori Izumi ,  Yasutaka Oda ,  Yuki Akiyoshi

IPC分类号： G01N33/566 ,  C07K16/06 ,  C07K16/18

CPC分类号： C07K16/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/52

摘要： The present invention has its main object of providing a method for determining prognosis scientifically by searching an early marker for predicting neurological prognosis in order to grasp the disease state of a patient with an acute central nervous system disorder in the early stage and enabling an appropriate treatment to be performed. The method for determining the prognosis is provided in which the expression level of SH3BGRL3 in the biological fluid of the patient within 48 hours after resuscitation from cardiopulmonary arrest is measured, and the prognosis of the disorder classified into a good prognosis group and a poor prognosis group depending on the expression level or the presence or absence of the expression based on the Glasgow Outcome Scale (GOS) is predicted.

摘要翻译： 本发明的主要目的是提供一种通过搜索用于预测神经预后的早期标记物来科学地确定预后的方法，以便在早期掌握患有急性中枢神经系统疾病的患者的疾病状态并且能够进行适当的治疗 被执行。 提供了确定预后的方法，其中测量了从心肺停止复苏后48小时内患者生物液体中SH3BGRL3的表达水平，并将该疾病的预后分类为良好的预后组和不良预后组 取决于表达水平或基于格拉斯哥结果量表（GOS）的表达的存在或不存在。

公开(公告)号：US20110065205A1

公开(公告)日：2011-03-17

申请号：US12532245

申请日：2008-03-27

申请人： Tsuyoshi Maekawa ,  Tomonori Izumi ,  Yasutaka Oda ,  Yuki Akiyoshi

发明人： Tsuyoshi Maekawa ,  Tomonori Izumi ,  Yasutaka Oda ,  Yuki Akiyoshi

IPC分类号： G01N33/566 ,  C07K16/18 ,  C07K16/06

CPC分类号： C07K16/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/52

摘要： The present invention has its main object of providing a method for determining prognosis scientifically by searching an early marker for predicting neurological prognosis in order to grasp the disease state of a patient with an acute central nervous system disorder in the early stage and enabling an appropriate treatment to be performed. The method for determining the prognosis is provided in which the expression level of SH3BGRL3 in the biological fluid of the patient within 48 hours after resuscitation from cardiopulmonary arrest is measured, and the prognosis of the disorder classified into a good prognosis group and a poor prognosis group depending on the expression level or the presence or absence of the expression based on the Glasgow Outcome Scale (GOS) is predicted.

摘要翻译： 本发明的主要目的是提供一种通过搜索用于预测神经预后的早期标记物来科学地确定预后的方法，以便在早期掌握患有急性中枢神经系统疾病的患者的疾病状态并且能够进行适当的治疗 被执行。 提供了确定预后的方法，其中测量了从心肺停止复苏后48小时内患者生物液体中SH3BGRL3的表达水平，并将该疾病的预后分类为良好的预后组和不良预后组 取决于表达水平或基于格拉斯哥结果量表（GOS）的表达的存在或不存在。

公开(公告)号：US5364520A

公开(公告)日：1994-11-15

申请号：US987758

申请日：1992-12-10

申请人： Tsuneo Okuyama ,  Tomonori Izumi ,  Masato Yamaguchi

发明人： Tsuneo Okuyama ,  Tomonori Izumi ,  Masato Yamaguchi

IPC分类号： G01N27/447 ,  C25B9/00

CPC分类号： G01N27/44747

摘要： A packing material for capillary electrophoresis comprises capillary electrophoresis in an apparatus having a capillary column, by charging a sample into an end of the capillary column and discharging the sample from the other end of the capillary column, is conducted using a capillary column prepared by packing the column with a packing material comprising glucomannan and then forming a gel in situ from the packed glucomannan. The packing material is packed into the capillary easily and forms a homogeneous gel therein which shows no damage by formation of bubbles and the like and thus can be utilized with stability, has superior health safety and is excellent with respect to biodegradation.

摘要翻译： 用于毛细管电泳的包装材料包括在具有毛细管柱的装置中的毛细管电泳，通过将样品装入毛细管柱的末端并从毛细管柱的另一端排出样品，使用通过包装制备的毛细管柱进行 该柱具有包含葡甘露聚糖的包装材料，然后从包装的葡甘露聚糖原位形成凝胶。 包装材料容易地包装在毛细管中，在其中形成均匀的凝胶，其中不会形成气泡等而没有损伤，因此可以稳定地使用，具有优异的健康安全性，并且在生物降解方面优异。